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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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180 answers

IVF Failure & Pregnancy Loss

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Egg Health & Ovarian Reserve Dec 5, 2023

Positive lads after 4th lit treatment

Dear Dr. Sher, Thank you for your answer. I did take ivig before pregnancy was diagnosed. Took 30g ivig on ovulation and on positive hgc test but it faild to relax my immune system. I refuse to take steroids as… — Irit L.

Dr. Geoffrey Sher answered

I Did 3 lit treatments 1.5 years ago. Lads were negative. After the last pregnancy loss I did the 4th lit. Finally lad became weak positive 40%. Do you think that positive lads gives me a better chance to carry a pregnancy? A: I do not believe this…
Immunology & Implantation Nov 28, 2023

Repeated miscarriages

Dear Dr. Sher, Just had my 6th miscarriage, natural conception with ivig and lit. I am disgnosed with partial dq-alpha gene match (0301) and elevated nk cells. We have a 4.5 years old son concieved naturaly and easily. My miscarriages… — Irit L.

Dr. Geoffrey Sher answered

Firstly, In order for treatment with IVIG or intralipid to work optimally, it must begin long before pregnancy is established. From your report it sounds as if the IVIG therapy only started after the pregnancy was diagnosed and that is too late. Second, treatment must of necessity also…
Embryos & Genetic Testing Nov 27, 2023

Miscarriage and Adenomyosis

Hi there I am 39 and since 33 have had recurrent miscarriages. I had two at 6.5 weeks and then a live baby and then 1 at 6.5 weeks that had two trisomies when tested. During that third miscarriage I… — Sophie T.

Dr. Geoffrey Sher answered

Adenomyosis can compromise implantation, but in my opinion this only occurs when the endometrial lining at the time of ovulation, hCG "trigger" or when progesterone treatment begins in cases of FET/embryo adoption etc. In fact in most cases adenomyosis is found in women who have had several babies,…
Age & Fertility Nov 20, 2023

IVF

This question is about reciprocal IVF. Im 21 and my wife is 58. She hasn’t reached menopause and I have irregular periods. I was diagnosed with infertility at a young age after a miscarriage. Who would you recommend to use… — Mikayla H.

Dr. Geoffrey Sher answered

Youn could do so, but I must caution you that there would be significant medical risk in a woman of 58Y carrying a pregnancy. Geoff Sher ++++++++++++++++++++++++++++++++++++++++++++++++ PLEASE SHARE THIS WITH OTHERS AND HELP SPREAD THE WORD!! Herewith are online links to 2 E-books recently co-authored with my…
Immunology & Implantation Nov 17, 2023

APS diagnosis, 1 successful FET, 3 failed FETs

Hi Dr. Sher, I'm here because, like many women who come to you, I have had multiple failed FETs. I did IVF back in 2017 due to male Factor infertility, azoospermia. I was 30 years old and my embryos were… — Kimberly N.

Dr. Geoffrey Sher answered

This very much sounds like an implantation dysfunction Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin…
IVF Failure & Pregnancy Loss Nov 13, 2023

recurrent pregnancy loss

Hi- I have recurrent unexplained pregnancy loss: Recently got a positive test and have the following HCG results… The third draws doubling time threw me off a bit but today had a good rise… any insight into what to expect… — Olivia D.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent pregnancy…
IVF Failure & Pregnancy Loss Nov 2, 2023

Doppler US – notch right at 13 weeks

Hello Dr Sher, I hope you're well. We just had a dating scan at 13w1d, they confirmed everything looks good. However, in the printed report, it states that for the Dopler Ultrasound there is a "notch right" - they didn't… — Cassidy O.

Dr. Geoffrey Sher answered

Frankly, I would not be overly concerned. And no,there is in my opinion nothing to do here. except follow up with ultrasound evaluations intermittently. Good luck! Geoff Sher Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading…
Egg Health & Ovarian Reserve Oct 30, 2023

Reoccurring failed implantation

Hi Dr. Sher, I found your website after researching pgt embryos that fail to implant. I’m 38 years old, I have DOR, AMH .5 when tested a year ago, FSH 10.3. I did three retrievals and ended up with 5… — Jill D.

Dr. Geoffrey Sher answered

Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success…
IVF Failure & Pregnancy Loss Oct 26, 2023

Recurrent biochemical pregnancy

I have three children born via IVF in 2018 2019 2020. After my last child, I had a incisional hernia that was repaired with MESH. Therefore, my doctor highly discouraged further pregnancies. We currently are using a surrogate. Our surrogate… — Ashley C.

Dr. Geoffrey Sher answered

It is likely just bad luck but bear in mind that even a perfect surrogate is not immune to developing implantation issues. Discuss the possibility that your surrogate might be one of these (as unlikely as this might seem). You might even consider switching surrogates. IVF FAILURE WITH…
Hormones & Ovulation Oct 26, 2023

Repeated Miscarriage

Hi Dr. Sher, Thanks so much for taking the time to read and answer our questions, and for the valuable resources on your site. I have PCOS and have had 4 losses, no live births yet. Each miscarriage at a… — Irma M.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent pregnancy…
Early Pregnancy & hCG Oct 26, 2023

5w 4d ivf

Hello, I am not one of your patients however I have been having issues with my current fertility clinic and I was just wondering Is how often an hcg should be pulled? .. .and is a patient Notify you that… — Sarah J.

Dr. Geoffrey Sher answered

You need to repeat the hCG blood test to see whether the levels are dropping. But, sadly, this sounds like a very early pregnancy loss to me. Going through IVF is a major investment, emotionally, physically, and financially, for every patient or couple. One of the most crucial…
Egg Health & Ovarian Reserve Oct 26, 2023

IVF

I have gone through two failed IVF cycles and have very low AMH 0.4.. is it possible for me to undergo another IVF with my own eggs — Samudika R.

Dr. Geoffrey Sher answered

Understanding the impact of age and ovarian reserve on the success of in vitro fertilization (IVF) is crucial when it comes to reproductive health. This article aims to simplify and clarify these concepts, emphasizing their significance in the selection of ovarian stimulation protocols for IVF. By providing you…
Fertility Preservation Oct 26, 2023

Dominant Follicle

I am currently on my second egg freezing cycle (35 years old). In my first cycle I had 11 follicles with 8 eggs frozen. I just began my second cycle 6 days ago and there is now a dominant follicle… — Courtney L.

Dr. Geoffrey Sher answered

It may have to do with a need to adjust your protocol for ovarian stimulation. Geoffrey Sher More About Dominant Follicle The journey of in vitro fertilization can be a rollercoaster of emotions for many patients. Often times they have to face the harsh reality that the number…
Immunology & Implantation Sep 25, 2023

Reproductive Immunology/RPL

Hi there, I just turned 42 w an AMH of 1.33-1.71 and have been undergoing IVF treatments for over three years with some success - I was pregnant twice, both unviable and resulting in two D&Cs. This is in addition… — Shian T.

Dr. Geoffrey Sher answered

In the world of assisted reproduction, when IVF fails repeatedly or without explanation, it's often assumed that poor embryo quality is the main culprit. However, this view oversimplifies the situation. The process of embryo implantation, which begins about six or seven days after fertilization, involves a complex interaction…
Embryos & Genetic Testing Sep 20, 2023

RPL

Hi Dr. Sher We started trying for a baby a year ago. Fast forward to now and I've had 2 chemical pregnancies, 1 missed miscarriage (embryos heart stopped at 6 weeks 3 days) and now a blighted ovum (gestational sac… — Marie N.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent pregnancy…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

180 answers

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