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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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178 answers

IVF Failure & Pregnancy Loss

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Embryos & Genetic Testing Jan 29, 2024

Multiple failures after live birth from IVF

My first FET in 2020 was successful and resulted in the birth of my son. Since 2022, I have had four more FETs: the first one failed to implant and the next three implanted but miscarried between 5-6 weeks. The… — Kelsey H.

Dr. Geoffrey Sher answered

Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success…
IVF Failure & Pregnancy Loss Jan 25, 2024

3 miscarriages back to back

I have a unicornuate uterus. I have had three miscarriages back to back. All of which end at 5 weeks. The second resulted in a D&C due to the embryo not growing. I'm currently going through the same issue. My… — Krista W.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent pregnancy…
Egg Health & Ovarian Reserve Jan 25, 2024

Atretic eggs

Good afternoon, I’m posting in English. Thank you very much for your answer. Last April my AMH was 0.04, even though I did my first IVF and got two follicles with two embryos. One of them ended up in a… — Carmen N.

Dr. Geoffrey Sher answered

“EMPTY FOLLICLE SYNDROME” “Empty Follicle Syndrome" is a misleading term because follicles always contain eggs. However, some eggs may have difficulties detaching and being retrieved. This is more likely to happen when multiple attempts are needed to retrieve an egg from a follicle, indicating the egg may have…
IVF Failure & Pregnancy Loss Jan 24, 2024

Atresia ovocitos

Tengo muy muy baja ovárica. He realizado 4 tratamientos FIV, el primero con letrozol y pergoveris (225 cada dos días) en el que obtuvimos 2 ovocitos maduros de dos folículos, llegaron a embrión los dos, implantamos uno pero acabó en… — Carmen N.

Dr. Geoffrey Sher answered

I would be happy to respond but I don't speak Spanish. So, could you re-post this in English please! Geoff Sher
Egg Health & Ovarian Reserve Jan 22, 2024

‘Empty’ follicles

Hello Dr. Sher, I just had an egg retrieval cycle where despite my follicles growing nicely and the clinic expecting to collect 15 eggs, they only retrieved 6 eggs, two of which have fertilised. Apparently, the ‘empty’ follicles contained cumulus… — Ruth A.

Dr. Geoffrey Sher answered

Empty Follicle Syndrome" is a misleading term because follicles always contain eggs. However, some eggs may have difficulties detaching and being retrieved. This is more likely to happen when multiple attempts are needed to retrieve an egg from a follicle, indicating the egg may have chromosomal abnormalities. The…
Embryos & Genetic Testing Jan 18, 2024

High testosterone and repeat chemical pregnancies

Hi Dr. Sher, I heard you on an episode of the Egg Whisperer. I have high testosterone from PCOS and have had one implantation failure and two chemical pregnancies. Could the high testosterone be the cause? My embryos were not… — Allison B.

Dr. Geoffrey Sher answered

Navigating Polycystic Ovary Syndrome: Understanding, Hope, and Treatment Understanding the intricate interplay of hormones and the impact on egg development empowers us to create personalized protocols, offering hope for improved egg quality and ultimately optimizing the chances of successful IVF for women with PCOS. Polycystic ovary syndrome (PCOS)…
Egg Health & Ovarian Reserve Jan 4, 2024

Multiple miscarriages

I am 30, my husband is 29. I was diagnosed with PCOS at 15. I had a miscarriage at age 20 at 8 weeks. Last year, I had three miscarriages (one at 6 weeks, 5 weeks and then at 4… — Kristina H.

Dr. Geoffrey Sher answered

Respectfully, I do not concur with the suggested approach. You have recurrent pregnancy loss. I suggest you read the articles I wrote , below and then seriously consider calling my assistant, Patti Converse at 702-533-to set up an online consultation with me to discuss your case in detail.…
IVF Failure & Pregnancy Loss Jan 3, 2024

Molar pregnancy and IVF

Can a woman that has had molar pregnancy twice within 4 years and undergone chemotherapy be advised to go for IVF? — Tony A.

Dr. Geoffrey Sher answered

It is possible Molar pregnancy or hydatidiform mole — is a benign tumor that occurs in the uterus. It starts when an egg is fertilized, but instead developing into a normal, conceptus + placental tissue, the placenta tissue develops into a mass of small cysts. Here, the root…
IVF Failure & Pregnancy Loss Dec 31, 2023

Chemicals pregnancy

I had 4 chemical pregnancies what should I do — Selemawit Z.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent pregnancy…
IVF Failure & Pregnancy Loss Dec 28, 2023

Quisiera tener una niña por un vidrio

Quisiera tener una niña por un vidrio porque murió también mi esposo y mi esposo siempre querido una niña — Diana R.

Dr. Geoffrey Sher answered

Please repost in English! Geoff Sher PLEASE SHARE THIS WITH OTHERS AND HELP SPREAD THE WORD!! Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: From In Vitro Fertilization to Family: A Journey with Sher Fertility…
Embryos & Genetic Testing Dec 23, 2023

Multiple Chemical Pregnancies

Hi Dr. Sher, This has been a long journey. I did a fresh transfer at 38 (got 18 eggs, 5 to blast stage, but we did not test then), the fresh transfer resulted in a chemical. Had to take some… — Mary R.

Dr. Geoffrey Sher answered

On the face of it, this sounds very much like3 "implantation dysfunction). Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as…
Immunology & Implantation Dec 20, 2023

FET + Intralipids + Medrol + Heparin = Miscarriage

Hi Dr. Sher, I listened to your podcast on RPL with Dr. Aimee on The Egg Whisperer. I'm 44F, I've had 2 FET's with 2 tested 4AA embryos. Both implanted, both failed to grow. I was on the kitchen sink… — Marissa D.

Dr. Geoffrey Sher answered

WE need to talk. Might I recommend that you call my assistant, Patti Converse at 702-533-2691 to set up an online consultation with me to discuss. Geoff Sher
IVF Failure & Pregnancy Loss Dec 10, 2023

Chemical Pregnancy

TTC 3+ years. One Tube removed from ectopic 17 years ago previous partner. AFC 11. 37years old. Elevated NK cells. 1 failed round of IVF. 3 IUI, 2 of which were recent and I had chemical pregnancy in both. One… — Anneka K.

Dr. Geoffrey Sher answered

Subject to confirmation through further consultation and testing, I believe your history to be highlyb suggestive of an implantation dysfunction (probably) partly or completely due to an immunologic cause. Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure…
Egg Health & Ovarian Reserve Dec 5, 2023

Positive lads after 4th lit treatment

Dear Dr. Sher, Thank you for your answer. I did take ivig before pregnancy was diagnosed. Took 30g ivig on ovulation and on positive hgc test but it faild to relax my immune system. I refuse to take steroids as… — Irit L.

Dr. Geoffrey Sher answered

I Did 3 lit treatments 1.5 years ago. Lads were negative. After the last pregnancy loss I did the 4th lit. Finally lad became weak positive 40%. Do you think that positive lads gives me a better chance to carry a pregnancy? A: I do not believe this…
Immunology & Implantation Nov 28, 2023

Repeated miscarriages

Dear Dr. Sher, Just had my 6th miscarriage, natural conception with ivig and lit. I am disgnosed with partial dq-alpha gene match (0301) and elevated nk cells. We have a 4.5 years old son concieved naturaly and easily. My miscarriages… — Irit L.

Dr. Geoffrey Sher answered

Firstly, In order for treatment with IVIG or intralipid to work optimally, it must begin long before pregnancy is established. From your report it sounds as if the IVIG therapy only started after the pregnancy was diagnosed and that is too late. Second, treatment must of necessity also…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

178 answers

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