Hi Dr. Sher,

Thanks so much for taking the time to read and answer our questions, and for the valuable resources on your site. I have PCOS and have had 4 losses, no live births yet. Each miscarriage at a different stage, 6w, 6w, 7w (ART), and 8.5w (ART). In particular, the last loss was from an euploid-tested embryo via IVF. We had a strong heart at 8 weeks yet our next scanning showed no heartbeat, yolk sac missing. It also showed lack of blood flow to the uterus in certain areas. For the last two pregnancies I was on a protocol, in the last one a “kitchen sink” approach included heparin, aspirin, levo, progesterone pessaries, hormones, metformin, vitamins. I’ve had some testing done, but not IR extensive and when asking my RE they don’t think this is necessary, I’ve inquired about endometriosis (my histeroscopy showed ok inside uterus) but keep being told by various Drs there is no relation from endo and my miscarriages as this would be outside the uterus. As well, given that I get pregnant easily, I have an unexplained diagnosis. Could endo be a reason, even if symptoms are not present? Could it be possible to check for endo through NK activation cell testing (or other type of testing) before laparoscopy (if Drs do not refer me for this)? I apologize for the long message, I’m trying to see if RI is something I should look into and advocate for my case before planning on doing another transfer with the same protocol – I only have an embryo left. Thanks!