Dr. Geoffrey Sher

Intrauterine Insemination (IUI): Who needs it and who does not; Pros and Cons

“As physicians we really need to seriously rethink the basis upon
which we recommend  IUI!” -GS Intrauterine insemination (IUI), the
injection of sperm into the uterus by means of a catheter directed
through the cervix, has been practiced for many years.  The premise
of this procedure is that sperm can reach and fertilize the egg more
easily if placed directly into the uterine cavity. IUI is a procedure
that bypasses the cervix and places specially p…

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Unexplained IVF Failure 2

When confronted with “unexplained” IVF failures where
morphologically good embryos were transferred, the question arises as
to whether the problem is due to inherent egg/embryo
“incompetence” (which usually equates with an irregular
chromosomal configuration [aneuploidy]) or whether it is due to an
implantation dysfunction. The younger the woman and the higher the
quality of available embryos (preferably blastocysts), the less likely
it is that the fau…

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Egg Freezing: Fertility Preservation (FP) & Commercial Donor Egg Banks

The bottom line is that because of the traumatic effect of freezing on
egg viability and “competency” the statistical chance of each
frozen/ thawed egg ultimately resulting in a baby is only at best
6-8%. So, while success rates following the transfer of embryos
derived from frozen eggs have indeed improved substantially over the
last 5-10 years, they remain significantly lower than when embryos
derived through fertilization of fresh (not frozen) eggs, are
transferred.

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Advantages of Combining Preimplantation Genetic Sampling (PGS) with Tests for Immunologic Implantation Dysfunction (IID)

Whenever IVF fails to resolve reproductive failure, the explanation is
almost invariably either:  a) embryo “incompetence” (usually
…although not always due to the embryo being karyotypically abnormal
or aneuploid) or b) implantation dysfunction (anatomical/
immunologic). So…should the transfer of  up to two (2)
karyotypically 

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IVF: The Economic Realities

Patrick Steptoe and Robert Edwards were responsible for the birth of
the world’s 1st IVF baby, Louise Brown, in 1978. Since then about 4
million babies have been born worldwide, and the number is growing
fast. The introduction of this Assisted Reproductive technology (ART)
which comprises IVF and associated procedure has literally
revolutionized the treatment of infertility and Reproductive failure
b…

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