Dr. Geoffrey Sher, Author at Sher Fertility Solutions | Begin Your Fertility Journey

The “Biological Clock” and How it Should Influence the Selection and Design of Ovarian Stimulation Protocols for IVF

It is inevitable reality that all women will at some point or another,
experience a progressive decline in their reproductive potential. This
occurs as their ovarian egg population falls below a theoretical
threshold. Ultimately once it is all but depleted, a total cessation
of ovulation and menstruation (the menopause) ensues making the chance
of having a baby with own eggs virtually impossible. This decline in
so called “ovarian reserve” usually star…

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PGT IN IVF: Some embryos that test PGT- chromosomally abnormal can self- correct in the uterus: Are we wrongly discarding embryos that are capable of developing into healthy babies?

By Dr. Geoffrey Sher

Human embryo development occurs through a process that encompasses
reprogramming, sequential cleavage divisions and mitotic chromosome
segregation and embryonic genome activation. Chromosomal abnormalities
may arise during germ cell and/or preimplantation embryo development
and represents a major cause of early pregnancy loss. About a decade
ago, I and my associate, Levent Keskintepe PhD were the first to
introduce full embryo karyotyping (identification of all 46
chromosomes) through pr…

PGT IN IVF: Some embryos that test PGT- chromosomally abnormal can self- correct in the uterus: Are we wrongly discarding embryos that are capable of developing into healthy babies? Read More »

Micro-IVF: Often Preferable to Ovarian Stimulation with or Without IUI

By Dr. Geoffrey Sher

Micro-IVF differs from “conventional IVF” in that when performed
on younger women (2.0ng/ml and basal FSH=

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IVF for Same Sex Couples

By Dr. Geoffrey Sher

Gay, lesbian, or transgender individuals experience the same fears as
any individual in the world. One of these is trepidation that they
might not be able to have children. In the United States of America,
same-sex marriage [https://en.wikipedia.org/wiki/Same-sex_marriage]
has been legal nationwide since June 26, 2015, when the United
States…

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IVF for Women Who Have Previously Conceived (Secondary Infertility)

By Dr. Geoffrey Sher

While _Primary infertility_ refers to the inability of a woman who has
never been pregnant in the past, to conceive, _Secondary Infertility_
is defined as an inability to conceive more than 1 year after having
conceived in the past. Most patients find it difficult to accept the
fact that having once been able to conceive they are now unable to do
so. When confronted with the proposition that they need IVF, women who
have Secondary Infertility find it harder to accept than d…

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IVF Outcome: How Age, Ovarian Reserve and the Protocol Used for Controlled Ovarian Stimulation (COS) Influences Success

By Dr. Geoffrey Sher

It is the egg’s numerical chromosomal integrity (ploidy) that is the
most influential in influencing its subsequent ability
post-fertilization, to propagate a “competent” embryo (one that
has 46 chromosomes and is capable of developing into a healthy
pregnancy). And it is the ploidy of the embryo that determines
reproductive success. Thus, egg ploidy is the rate-limiting factor in
human reproduction. Ovarian reserve refers to the number of eggs
remaining in the ovaries. An AMH o…

IVF Outcome: How Age, Ovarian Reserve and the Protocol Used for Controlled Ovarian Stimulation (COS) Influences Success Read More »

Immunologic Implantation Dysfunction: Importance of Meticulous Evaluation and Strategic Management: (Case Report)

By Dr. Geoffrey Sher

Greetings Dr. Sher! Just wanted to first thank you for all that you do
for women and infertility and I’m truly amazed and grateful at how
you are so willingly to share your knowledge and help women achieve
pregnancy. As for me, my background – Diagnosed with endometriosis
at age 19 when I lost one ovary/tube. Struggled with recurrent endo
and had multiple surgeries for endometriomas. Stayed on continuous BCP
for more than 15 years. At about 37 tried a few rounds of in vitro,
low slow…

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Sperm DNA Damage- Tests and Interpretation

By Dr. Geoffrey Sher

THE SPERM CHROMATIN STRUCTURE ASSAY (SCSA): A MEASURE OF THE POTENTIAL
OF SPERM TO HELP PROPAGATE A VIABLE PREGNANCY In about 40% of
infertility cases, male factor is the sole cause. In approximately
another 40% it is solely a female factor and in the remainder (20%)
both male and female factors are involved. In more than 80% of cases,
performance of a semen analysis (sperm concentration, motility, and
morphology) will be sufficient to diagnose male factor. There is
grow…

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Ovarian Endometriomas: Sclerotherapy provides a Safe, Convenient, and highly effective Non-Surgical Alternative

By Dr. Geoffrey Sher

Women, who have advanced endometriosis, often have endometriotic
ovarian cysts, known as endometriomas. These cysts contain decomposed
menstrual blood that looks like melted chocolate…hence the name
“chocolate cysts”. These space occupying lesions can cause chronic
pelvic pain, pain with intercourse (dyspareunia) and painful menstrual
periods, thus compromising quality of life. They can also activate
ovarian connective tissue (stroma or theca) result…

Ovarian Endometriomas: Sclerotherapy provides a Safe, Convenient, and highly effective Non-Surgical Alternative Read More »

Measuring and interpreting Blood hCG to Assess Pregnancy Viability Following ART Treatments

By Dr. Geoffrey Sher

I know of no medical announcement associated with the degree of
emotional anticipation and anguish as that associated with a pending
diagnosis/confirmation of pregnancy following infertility treatment.
In fact, hardly a day goes by where I am not confronted by a patient
anxiously seeking interpretation of a pregnancy test result.

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Dr. Geoffrey Sher

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