Endometriosis Mechanism of Infertility

 

Endometriosis is known to have a profoundly significant negative
effect on fertility.  Normal natural pregnancy rates are in the range
of 0.15 to 0.20 per month and decrease with age, but women with
endometriosis tend to have a lower monthly rate of about 0.02–0.1
per month.  Conversely, infertile women are 6 to 8 times more likely
to have endometriosis than fertile women. 
Why does endometriosis cause infertility?   The inflammation
associated with endometriosis ca…

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“Silent” Endometriosis

 
Endometriosis is a pelvic inflammatory disease attributable to ectopic
implants of uterine lining (endometrium) establishing a foothold in
inappropriate locations in the pelvis, especially the ovaries, the
peritoneal lining, and the bladder.  It is believed that retrograde
menstrual flow through the fallopian tubes allows some still viable
endometrial cells to enter the pelvis and implant where it lands.  In
unusual circumstances, endometrial cells can travel and establish
the…

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Controlled Ovarian Stimulation (COS) for IVF: Selecting the ideal protocol

 
In order for any organism to attain an optimal state of maturation
(ripening) it must first undergo full growth and development. A fruit
plucked from a tree before having developed fully or a poorly
developed fruit might still ripen (mature) on the shelf and might even
appear as enticing as one that had previously undergone proper
development, but it will lack the same quality. The same principles
apply to the development and maturation of h…

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Diagnosing and Treating Infertility due to Diminished Ovarian Reserve (DOR)

 
_Ovarian reserve_ is the term used to describe the extent of a
woman’s ovarian egg supply. Diminished ovarian reserve (DOR) refers
to a reduction in the total number of eggs left in the ovaries such
that resistance builds to ovarian stimulation with fertility drugs.
With progressively diminishing ovarian reserve, an ever increasing
amount of fertility drugs is required to stimulate optimal follicle
and egg development…

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Hereditary Clotting Defects (Thrombophilia)

 

Thrombophilia (Hereditary Clotting Defect) is defined as the genetic
predisposition to developing intravascular thrombosis. It is due to
hypercoagulability of blood leading to impairment of initial
vascularization that takes place during implantation.
Thrombophilia affects as many as one in five people in the United
States and is responsible for pregnancy loss (most particularly after
the 1st tri…

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IVF: FACTORS AFFECTING EGG/EMBRYO “COMPETENCY” DURING CONTROLLED OVARIAN STIMULATION (COS)

 
The potential for a woman’s eggs to undergo orderly development and
maturation, while in large part being genetically determined can be
profoundly influenced by the woman’s age, her “ovarian reserve”
and proximity to menopause. It is also influenced by the protocol used
for controlled ovarian stimulation (COH) which by fashioning the
intra-ovarian hormonal environment, profoundly impacts egg development
and maturation.

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Selective Banking of Genetically Tested Donor Eggs

 
As a woman ages beyond 30 years, the quality of her eggs starts to
decline progressively and with it also her fertility potential. By age
40 she is about half as likely to conceive and by her mid forties she
will be approximately, 10 times less fertile. This holds true for
natural conception as well as for conception following IVF. For more
than a quarter century scientists have attempted to defy the
biological clock by freeze-storing a woman’s eggs to preserve her
fertility.Â…

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