– Geoffrey Sher, MD
Fill in the following information and we’ll get back to you.
Search 1,017 questions patients have already asked, or narrow them by topic.
Immunology & Implantation
Buenos días mi pregunta es si se mezclan los intralipidos en solución salina para administrar los.Gracias — Vanya S.
Dr. Drew Tortoriello answered
_Please Re-post in English! Geoff Sher PLEASE SHARE THIS WITH OTHERS AND HELP SPREAD THE WORD!! Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: From In Vitro Fertilization to Family: A Journey with Sher Fertility…
Embryos & Genetic Testing
Hi there, I hope you are well. I had failed pgs tested 3AA embryo donation. Era receptive microbiom recently tested lactobacillus — Private
Dr. Geoffrey Sher answered
Understanding the impact of age and ovarian reserve on the success of in vitro fertilization (IVF) is crucial when it comes to reproductive health. This article aims to simplify and clarify these concepts, emphasizing their significance in the selection of ovarian stimulation protocols for IVF. By providing you…
Embryos & Genetic Testing
What is the recommended transfer protocol for someone with high TNF Alpha. I was given prednisone but it did not work. Prior to transfer it was 45.0 and I was prescribed 25mg prednisone for a month but it increased to… — Private
Dr. Geoffrey Sher answered
Elevated TNF alpha indicates activated natural killer cell activity. A RATIONAL BASIS FOR MANAGEMENT OF IMMUNOLOGIC CAUSES OF EMBRYO IMPLANTATION DYSFUNCTION In the world of assisted reproduction, when IVF fails repeatedly or without explanation, it's often assumed that poor embryo quality is the main culprit. However, this view…
Immunology & Implantation
Hello Dr. Sher, I'm hoping you can provide me some insight and comfort. Quick history - I have had 6 early losses prior to 7 weeks over 4 years. After a lot of testing and trials with my RE, we… — Jessica B.
Dr. Geoffrey Sher answered
Anything is possible, and I hope it works out. However, it would be of no value in my opinion, to start with immunotherapy now. Intralipid therapy should be initiated 10-14 days before conception to be of significant help! Good luck and G-d bless! Geoff Sher
Embryos & Genetic Testing
I hope you can advise me on the situation below. I had Pregmune testing completed in January 2023. It showed my husband and I have DQ alpha match: DQ Alpha - full match, DQ Beta - partial match, HLA-DRB1 -… — Vilma C.
Dr. Geoffrey Sher answered
From your description, it certainly sounds as if your failures are due to an implantation dysfunction...likely, an immunologic implantation dysfrunction (IID). If so, then you MUST have a concommitant natural killer cell activation (NKa). Even though endometriosis can result in an autoimmune IID, and a matchibng D alpha…
Immunology & Implantation
Hi Dr. Sher, I heard you on a recent episode of the Egg Whisperer. I am 35 and I was recently diagnosed with Hashimotos with very high antibodies ( 300 TPO and 900 TgAB). I recently had a failed FET… — Ana K.
Dr. Geoffrey Sher answered
A RATIONAL BASIS FOR MANAGEMENT OF IMMUNOLOGIC CAUSES OF EMBRYO IMPLANTATION DYSFUNCTION Geoffrey Sher MD In the world of assisted reproduction, when IVF fails repeatedly or without explanation, it's often assumed that poor embryo quality is the main culprit. However, this view oversimplifies the situation. The process of…
Immunology & Implantation
Hi Dr Sher, I’m at a crossroads and desperate for advice. I’m 34 and my husband and I did 3 rounds of IVF to bank 4 euploid embryos. While I have low amh/DOR — my euploid rate was 80%. I… — Mel M.
Dr. Geoffrey Sher answered
WE should talk: I suggest you call my assistant, Patti at 702-533-2691 and set up an online consultation with me. When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up…
Immunology & Implantation
Hi Dr. Sher, I was initially given your name from a friend of mine who had complex fertility issues and great success under your care. I have tested pregnant five times over the past 18 months and either had chemical… — Danielle K.
Dr. Geoffrey Sher answered
This is problematic because you have a total match + NK cell activation. This makes the chance of you carrying your own baby very small regardless of you being treated with LIT/steroids; IVIG/steroids or Intralipid/steroids. We should talk. I suggest you contact my assistant, Patti Converse at702-533-261 and…
Embryos & Genetic Testing
Hi Dr. Sher, This has been a long journey. I did a fresh transfer at 38 (got 18 eggs, 5 to blast stage, but we did not test then), the fresh transfer resulted in a chemical. Had to take some… — Mary R.
Dr. Geoffrey Sher answered
On the face of it, this sounds very much like3 "implantation dysfunction). Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as…
Immunology & Implantation
Hi Dr. Sher, I listened to your podcast on RPL with Dr. Aimee on The Egg Whisperer. I'm 44F, I've had 2 FET's with 2 tested 4AA embryos. Both implanted, both failed to grow. I was on the kitchen sink… — Marissa D.
Dr. Geoffrey Sher answered
WE need to talk. Might I recommend that you call my assistant, Patti Converse at 702-533-2691 to set up an online consultation with me to discuss. Geoff Sher
Egg Health & Ovarian Reserve
Dear Dr. Sher, Thank you for your answer. I did take ivig before pregnancy was diagnosed. Took 30g ivig on ovulation and on positive hgc test but it faild to relax my immune system. I refuse to take steroids as… — Irit L.
Dr. Geoffrey Sher answered
I Did 3 lit treatments 1.5 years ago. Lads were negative. After the last pregnancy loss I did the 4th lit. Finally lad became weak positive 40%. Do you think that positive lads gives me a better chance to carry a pregnancy? A: I do not believe this…
Embryos & Genetic Testing
I just had a miscarriage at 5 weeks 4 days of a tested normal embryo 5 day AA PGT . And I tried to get pregnant for over 10 years. I was told I had an immunity disorder years ago,… — Sheyla M.
Dr. Geoffrey Sher answered
Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success…
Egg Health & Ovarian Reserve
Hi Dr Sher I have recently discovered your work and am curious if you think I should pursue an autoimmune protocol for IVF. I'm 40 years old and have undergone 2 unsuccessful cycles of IVF this year. I have been… — Jen M.
Dr. Geoffrey Sher answered
The fact that you have conceived before does not rule out an immunologic implantation dysfunction (IID). If so, you endometriosis and hypothyroid states would favor an autoimmune IID rather than alloimmune. However since treatment differs for each of these, a diagnosis is imperative. Your diminished ovarian reserve merely…
Immunology & Implantation
Dear Dr. Sher, Just had my 6th miscarriage, natural conception with ivig and lit. I am disgnosed with partial dq-alpha gene match (0301) and elevated nk cells. We have a 4.5 years old son concieved naturaly and easily. My miscarriages… — Irit L.
Dr. Geoffrey Sher answered
Firstly, In order for treatment with IVIG or intralipid to work optimally, it must begin long before pregnancy is established. From your report it sounds as if the IVIG therapy only started after the pregnancy was diagnosed and that is too late. Second, treatment must of necessity also…
Immunology & Implantation
Hi my wife and I have a partial dq alpha gene match our first child was Ivf my wife did intralipids and steroids clexane we conceived our son naturally 9 months after our daughter was born and she went back… — Dean W.
Dr. Geoffrey Sher answered
You were very lucky to conceive and have a successful pregnancy without using IVF with your immunotherapy. You are best advised to combine the two for this attempt! IMMUNOLOGIC IMPLANTATION DYSFUNCTION (IID) There is a growing recognition that problems with the immune function in the uterus can lead…
