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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

  • Dear Patients,

    I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

    – Geoffrey Sher, MD

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Search 1,006 questions patients have already asked, or narrow them by topic.

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  1. Immunology & Implantation

    Suggestions before another fet transfer

    Hello Dr. Sher, As background, We have been trying to conceive naturally for 2 years. We failed 2 ivf transfers ( both times Fet transfers with confirmed viable euploid blastocysts. 1st transfer was a double blastocyst transfer which's resulted in… — Ben U.

    Dr. Geoffrey Sher answered

    It certainly sounds as if you do have an implantation dysfunction. However, in my opinion these tests done are not adequate. I suggest you contact Patti Converse (my assistant) at 702-533-2691 and set up an online consultation with me to discuss in detail. Geoff Sher IVF FAILURE WITH…

  2. Immunology & Implantation

    Kir y hla

    Buenas tardes, nuestro caso mi mujer es kir A/B y c1/c2 mientras yo soy c2c2. Hemos tenido 5 fiv con dgp las dos ultimas, pruebas de trombofilias bien, biopsia endometrial bien y esperma bien. Me gustaria saber si existe en… — Cristian O.

    Dr. Geoffrey Sher answered

    Please re-post in English! Geoff Sher

  3. Immunology & Implantation

    HLA-DQA complete match

    Hi Dr Sher I am looking for any supportive data for the claim that complete HLA-DQA matching is impossible to treat with immune therapy. Can you help? Thanks Gavin — Gavin S.

    Dr. Geoffrey Sher answered

    Unless there is a concomitant NK cell activation, a DQ alpha match is in my opinion irrelevant and no treatment is required. There has to be both NKa+ a match. This is regardless of whether iot is a "partial" or a complete match. A partial match is treatable…

  4. Early Pregnancy & hCG

    IVF treatment plan question with immunological problem

    Dear Dr Sher, I am a 35 years old woman and I have fallopian tube blockage. I have had 4 IVF cycles, 3 were unsuccessful, the second was successful (at the beginning hcg:5000, progesterone: 34), but unfortunately I had to… — Flora K.

    Dr. Geoffrey Sher answered

    It seems highly likely that you do have an immunologic implantation dysfunction. Your endometrial cytoikine and NK cell elevation are suggestive. However, the cause must firsdt be identified before treatment can be defined for FET. This will require a detailed assessment (see below). A RATIONAL BASIS FOR MANAGEMENT…

  5. Immunology & Implantation

    Immune Issues/ DQ Alpha Match?

    Hi Dr Sher, My husband and I had our son 5 years(+3 months) ago. He was conceived after just 2 months trying. We have been experiencing secondary infertility for over 4 year +3 months. I have had 5 embryos fail… — Joanna B.

    Dr. Geoffrey Sher answered

    I think we should talk. Please contact my assistant, Patti Converse at 702-533-2691 or email her at concierge@sherIVF.com to set up an online consultation with me. Geoff Sher UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other…

  6. Immunology & Implantation

    IVF medication regiment

    I am seeing Dr Klitz at Cny fertility. I have had two filled IUI and two filled IVF. I have no health history besides a tilted uterus. My husband, sperm mythology is low and abnormal, but does have some normal… — Victoria S.

    Dr. Geoffrey Sher answered

    If you've undergone in vitro fertilization (IVF) and didn't achieve a successful pregnancy, you may be wondering why. It's important to know that IVF outcomes can be unpredictable, but there are factors that can affect your chances. Let's explore some common reasons for IVF failure in simpler terms.…

  7. Immunology & Implantation

    RPL and hydroxychloroquine

    Hi Dr Sher, I've been getting mixed advice from consultants and I'm hoping you can help. I'm 40years old and have one child, conceived with no issues, and have had a number of chemical pregnancy losses. I'm conceiving very easily,… — Bronagh M.

    Dr. Geoffrey Sher answered

    Thanks for the inquiry. I think I can help here. Might I suggest that you contact my assistant Patti Converse at 702-533-2691 and set up an online consultation with me to discuss in depth. Geoff Sher When it comes to reproduction, humans face challenges compared to other mammals.…

  8. Immunology & Implantation

    prednisone & prograf

    Hello, What are your thoughts about using prednisone and/or prograv for a FET with donor eggs? — Bree M.

    Dr. Geoffrey Sher answered

    In my opinion, the use of low dosage oral steroids is potentially beneficial for the vast majority of embryo transfers as it modulates immune=receptivity of the uterine lining. Geoff She

  9. Embryos & Genetic Testing

    Failed FET w/ Autoimmune disorder

    Hello Dr. Sher, I listen to your podcast with Dr. Aimee Eyvazzadeh and I wanted to engage with you before going into another FET w/egg donor my questions to you: 5 year IVF Journey/History: * Zero pregnancy * 2 Aneuploid… — Rosalyn G.

    Dr. Geoffrey Sher answered

    Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success…

  10. Embryos & Genetic Testing

    HLA matching

    Hello, I compared the markers of different HLA genes between myself and my husband from our raw genetic data which was produced by 23andMe and I found the following: 1. HLA-A: 3/3 markers matched = 100% 2. HLA-B: 2/4 markers… — Holly S.

    Dr. Geoffrey Sher answered

    This is too complex for me to respond to authoritatively here. I request that you call my assistant, Patti Converse (702-533-2691) and set up an online consultation with me to discuss. Geoff Sher

  11. Immunology & Implantation

    Secondary Recurrent Pregnancy Loss and possible IID

    Hi Dr Sher, I am 40 years old and have suffered with a number of early pregnancy losses in the past year, all conceived naturally. I have a 3 year old son who was conceived easily with no issues during… — Bronagh M.

    Dr. Geoffrey Sher answered

    When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent pregnancy…

  12. Early Pregnancy & hCG

    APA and early pregnancy

    Hi Dr Sher, I'm hoping you can help me, I've been reading your info on IID and the use of baby aspirin and clexane, and think it could apply to me. I'm 30 years old and have recently conceived after… — Nat M.

    Dr. Geoffrey Sher answered

    When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent pregnancy…

  13. Immunology & Implantation

    Recurrent miscarriage

    Dr sher In the past 2 years I have had 2 mmc one at 6 weeks and one at 9 weeks. The products were tested of the 9 week one it was genetically normal. After that I have had 3… — Tara B.

    Dr. Geoffrey Sher answered

    Having done the tests you describe has no real merit if they were not done at one of about 4 Reproductive Immunology Laboratories in Th US that can do these tests with optimal specificity and sensitivity. We need to talk! I invite you to contact my assistant, Patti…

  14. Embryos & Genetic Testing

    Failed donor embryo FET

    Hi there, I hope you are well. I had failed pgs tested 3AA embryo donation. Era receptive microbiom recently tested lactobacillus — Private

    Dr. Geoffrey Sher answered

    Understanding the impact of age and ovarian reserve on the success of in vitro fertilization (IVF) is crucial when it comes to reproductive health. This article aims to simplify and clarify these concepts, emphasizing their significance in the selection of ovarian stimulation protocols for IVF. By providing you…

  15. Embryos & Genetic Testing

    High TNF alpha

    What is the recommended transfer protocol for someone with high TNF Alpha. I was given prednisone but it did not work. Prior to transfer it was 45.0 and I was prescribed 25mg prednisone for a month but it increased to… — Private

    Dr. Geoffrey Sher answered

    Elevated TNF alpha indicates activated natural killer cell activity. A RATIONAL BASIS FOR MANAGEMENT OF IMMUNOLOGIC CAUSES OF EMBRYO IMPLANTATION DYSFUNCTION In the world of assisted reproduction, when IVF fails repeatedly or without explanation, it's often assumed that poor embryo quality is the main culprit. However, this view…

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