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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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231 answers

Embryos & Genetic Testing

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Embryos & Genetic Testing Jan 22, 2023

Repeated Chemical Pregnancies

I have done 3 FETs with PGT-A tested euploid embryos. Results were 1 pregnancy that ended at 14.5 weeks due to genetic abnormalities, followed by 2 chemical pregnancies in the last 8 months. Since my 14.5 week loss, I have… — Alysa W.

Dr. Geoffrey Sher answered

RECURRENT PREGNANCY LOSS (RPL) Geoffrey Sher MD. When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost…
Embryos & Genetic Testing Jan 18, 2023

Day 7 embryo

Hello doc. Our last euploid embryo is day 7 cc grade. We’re not very optimistic to be honest. What are the success rates of day 7 embryos? I have read some mixed data. I was 29 at time of egg… — A. A.

Dr. Geoffrey Sher answered

Respectfully, the success rate with day-7 blastocysts is very poor...even if it is assessed as being euploid Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro…
Embryos & Genetic Testing Jan 17, 2023

Implantation testing

Hi Dr Sher, I hope all is well. I just received my results for implantation tests and I was told that my vaginal microbiome was "low" - good bacteria content was low. The advice to do not do anything, just… — Cassidy O.

Dr. Geoffrey Sher answered

I do not believe in Microbiome testing. Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium)…
Embryos & Genetic Testing Jan 7, 2023

5th embryo transfer failed

What can you advise for me to do after my 5th embryo is unsuccessful? Thank you and appreciated your response. — Ruby H.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
Egg Health & Ovarian Reserve Dec 27, 2022

Are my poor outcomes just related to age?

[et_pb_section admin_label="section"] [et_pb_row admin_label="row"] [et_pb_column type="4_4"][et_pb_text admin_label="Text"]Hello, I had my daughter via ivf aged 40 after 2 cycles (first and only FET). Have been trying for a second (aged 41-42 years) over 4 cycles. My AMH is 31 and I… — Kay L.

Dr. Geoffrey Sher answered

Age could well be a factor, however, the protocol used for ovarian stimulation should be reviewed and if need be, revised. Also, I do suggest doing PGT on all blastocyst sand selective transferring only "competent" ones. Geoff Sher The importance of the IVF stimulation protocol on egg/embryo quality…
Embryos & Genetic Testing Dec 20, 2022

Dental bone graft before FET

Hi Dr.Sher, Thank you for taking the time to answer my question. A month prior to my FET I had dental bone graft placed. I took a full course of antibiotics and the healing was uneventful. Following month, my FET… — Ramya S.

Dr. Geoffrey Sher answered

The dental surgery and antibiotics would not have affected outcome. ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions…
Embryos & Genetic Testing Dec 14, 2022

Fever after FET

I had my FET 3 days ago of two embryos and 36 hours later experienced cold/flu symptoms (sore throat, cough, headache) which was accompanied by a rising temperature, which went up to 100.6. Can this negatively impact implantation? I am… — Victoria R.

Dr. Geoffrey Sher answered

Let me assure you that this is not due to your body reacting to the embryo(s). It is likely unrelated to the FET. I suggest you see your doctor and be evaluated to make sure it is not Covid. In the interim, try to keep your temperature down…
Embryos & Genetic Testing Dec 3, 2022

3 failed pgs donor fet transfers

Hi Dr. Sher, I have a child conceived naturally at 39 and then two early miscarriages also natural conception (first loss at 6 weeks and second loss at 7 weeks prior to heartbeat being detected) at age 42 and age… — Eliana B.

Dr. Geoffrey Sher answered

This is highly likely to at least in part, be due to a secondary implantation dysfunction (see below). While not definitive, I suspect an immunologic implantation dysfunction (IID). The fact that you have had a child already means that it if an IID exists, it is possibly alloimmune…
Embryos & Genetic Testing Nov 30, 2022

FET Protocol Opinion

Hi, I just wanted a second opinion on what my FET protocol looks like given my personal situation. I was diagnosed with endometriosis via laparoscopy in 2018. I did a total of 6 IUIs in 2021-2022 with my 4th one… — Taylor A.

Dr. Geoffrey Sher answered

This is an inordinate drop off from egg to "competent" embryo. In my opinion, , in spite of your borderline AMH (1.48ng/ml) which would suggest otherwise, you are a high responder to fertility drugs. The most likely explanation for your poor egg to "competent" embryo conversion has to…
Embryos & Genetic Testing Nov 29, 2022

What causes embryos to arrest during development?

I recently completed my 2nd egg retrieval at age 36 and had very different results. I have PCOS (high AMH =15 and many follicles, regular periods, thin/normal BMI ) and respond well to meds. We used 75 Menopur, 100 Gonal… — Maya S.

Dr. Geoffrey Sher answered

It could be an inherent underlying egg defect. However, more commonly it has to do with the selection of an optimal protocol for ovarian stimulation, the type of "trigger used" and the implementation of said protocol. The importance of the IVF stimulation protocol on egg/embryo quality cannot be…
Embryos & Genetic Testing Nov 23, 2022

32, 3 failed IUIs, 1 failed IVF transfer

Hi, I’m 32 years old and was diagnosed with mild endo which was removed last year. I’ve also had a few polyps, fibroids and cysts removed in the past 2 years. I had 3 failed IUIs and recently my first… — Miranda B.

Dr. Geoffrey Sher answered

I suggest we talk. Please consider calling Patti Converse (my assistant) at 702-533-2691 and set up an online consultation with me to discuss. When women with infertility due to endometriosis seek treatment, they are all too often advised to first try ovarian stimulation (ovulation Induction) with intrauterine insemination…
Embryos & Genetic Testing Nov 14, 2022

steroids for raised TH1/TH2 assay

I had my first child with no difficulty. followed by 3 losses due to chromosomal issues then went to IVF and had 1 successful birth! We have been trying for the last 4 years and it has resulted in 2… — Tasnem A.

Dr. Geoffrey Sher answered

Your raised TH1: TH2 suggests activated uterine natural killer cells. In your case, having had a child already, this suggests that it is alloimmune rather than autoimmune, immunologic implantation dysfunction (IID). This would require a different approach to treatment. First, however you need to establish a diagnosis. We…
Embryos & Genetic Testing Nov 7, 2022

Thin Endometrium

Hello Dr., I am currently 36 with unexplained infertility. We sought help in 2019 and ended up with a successful IVF cycle, 7 PGS -tested normal embryos (1 day 5 and 6 day 6). We transferred our day 5 embryo… — Natasha B.

Dr. Geoffrey Sher answered

Obviously I cannot with certainty define the cause of your thin lining. I can tell you 2 things: 1. A lining of
Embryos & Genetic Testing Nov 7, 2022

Permutation Fragile X

I have have had 2 pregnancies, 1 resulted in miscarriage and the other resulted in mono-di girls. I am a permutation fragile x carrier and they have the gene as well. Myself and my husband would like to go through… — Randi T.

Dr. Geoffrey Sher answered

The answer to both questions is yes! Fragile X syndrome occurs in individuals who carry the gene, FMR1 on an X-chromosome. This condition is inherited as a dominant X-linked disorder. With a dominant disorder, the condition results when there is only one copy of the altered gene in…
Embryos & Genetic Testing Oct 31, 2022

Euploid embryo transfer after giving birth

Dear Dr Sher, I have just given birth to baby son ( September 3d). The pregnancy was miracle due to natural conception in December last year. I delivered naturally (not C-section) at 39 weeks 4 days so at full term.… — Sayora G.

Dr. Geoffrey Sher answered

I would use both the euploid blastocysts. My suggestion is that once you have stopped breast feeding and are menstruating regularly you proceed to FET. Good luck!

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

231 answers

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