– Geoffrey Sher, MD
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Embryos & Genetic Testing
Need your support to access my ebryos by AI — Prashant S.
Dr. Geoffrey Sher answered
Not sure how to advise you! Sorry! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS)…
Early Pregnancy & hCG
Hello Dr. Sher, We transferred a single 5-day blastocyst January 30th. Our first hcg level was 1005 miu/ml at 14 days post-transfer, and 2nd hcg was 2200 miu/ml at 16 days. Two fetuses were present when we went in for… — Ian M.
Dr. Geoffrey Sher answered
In my opinion, the chance that the 2nd twin will be OK, is good! G-d bless and good luck! Geoff Sher
Embryos & Genetic Testing
After having had several failed implantations of healthy embryos, I did blood tests and obtained very high values of Factor X activity, clothing, and Factor XII activity clothing. What does it mean and how does it affect me? What's the… — Sofia G.
Dr. Geoffrey Sher answered
I really don't think this is likely to be a problem. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with…
Embryos & Genetic Testing
Hello Dr Sher! I was wondering if any of these "aneuploid" embryos stand a chance? I was wondering if I could maybe implant any, and if yes can I implant more than one at a time? Thank you :) 1.… — Tina F.
Dr. Geoffrey Sher answered
If any are"mosaic" they could auto correct in the uterus. Discuss with your RE. EMBRYO MOSAICISM: WHAT IS IT AND WHAT ARE THE CONSEQUENCES? Geoffrey Sher MD Human embryo development occurs through a process that encompasses reprogramming, sequential cleavage divisions and mitotic chromosome segregation and embryonic genome activation.…
Embryos & Genetic Testing
After four losses (ages 23, 32, and 33) I was diagnosed with one copy of PAI-1 and one copy of MTHFR. I also have very high thyroid antibodies. Could all of this be causing the losses? We are moving on… — Mary P.
Dr. Geoffrey Sher answered
I doubt that the heterozygous PAI-1 and one copy of MTHFR can explain the losses. the thyroid antibodies is however another matter ...see below. Geoff Sher Between 2% and 5% of women of the childbearing age have reduced thyroid hormone activity (hypothyroidism). Women with hypothyroidism often manifest with…
Embryos & Genetic Testing
Hi! We just had our baby girl (4BB). Are the odds better doing a transfer for a second child since the first one worked? We had MFI and are 28! We transferred two embryos the first time (4AA & 4BB)… — Megan W.
Dr. Geoffrey Sher answered
I think your chance of success is good. I personally am willing to transfer up to 2 embryos at a time unless there is a specific obstetrics contraindication against twins. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my…
Embryos & Genetic Testing
We are planning to transfer our previous frozen embryo, and I did currently semen analysis and found uroplasma, do my wife need an antibiotic before transferring the frozen embryo, and if yes what is the antibiotic and what is the… — Yousef S.
Dr. Geoffrey Sher answered
Ureaplasma urealyticum is a bacterium that belongs to the mycoplasma family. It can be detected in the reproductive tract of as many as 40% of individuals (male and female). Ureaplasma probably does not prevent normal conception in the majority of cases, because by and large, the uterine cavity…
Embryos & Genetic Testing
Hello, my husband and I have had a total of 6 good/top quality day 5 embryos implanted over the course of 2 years (2021- present). I have endometriosis, which I had surgery for in 2021. Following this surgery we had… — Ashley C.
Dr. Geoffrey Sher answered
Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or immunologic factors. IVF success rates…
Embryos & Genetic Testing
Hi, I learned of your clinic today on the egg whisperer and several questions arose from that video. I’ve had one retrieval with six day 5 embryos. My first fresh transfer failed with no implantation and my second was a… — Mary E.
Dr. Geoffrey Sher answered
There is a possibility that the hydrosalpinges could be playing a role here. However, it is important to also consider the possibility of an anatomical and/or immunologic implantation dysfunction. Please read below and then, if you are interested, contact my assistant Patti Converse (702-533-2691) and set up an…
Embryos & Genetic Testing
Hi Dr. Sher, I am an IVF patient of Dr. Randall Loy (RE) at the Center for Reproductive Medicine in Winter Park, Florida. I am also a patient of Dr. Jubiz Giovanni (RI) in Kissimmee, Florida. After two losses and… — Michelle R.
Dr. Geoffrey Sher answered
ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS) “ http://sherfertilitysolutions.com/sher-fertility-solutions-ebook.pdf “Recurrent Pregnancy Loss and Unexplained IVF Failure:…
Embryos & Genetic Testing
Hi Dr Sher, do you believe its okay to get a Sonohysterogram done during cycle day 6 - 11 of a medicated Frozen Embryo Transfer cycle? Can the medication (Estrogen and Progesterone) interfere with the SHG results or vice-versa? — Jennifer L.
Dr. Geoffrey Sher answered
Respectfully! I personally would not perform a SNH during a cycle of FET! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A…
Embryos & Genetic Testing
Hi, to add on to my last question. 3 miscarriages (1 at 6 weeks before heartbeat, 2 measuring 9 weeks after strong heartbeat detected with one being a PGT normal embryo). The only thing that we have found is one… — Kaitlin M.
Dr. Geoffrey Sher answered
A heterozygous MTHFR mutation will in my opinion, not cause early pregnancy loss. When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30%…
Embryos & Genetic Testing
Hi Dr. Scher! I've been listening to a few of your interviews with Dr. Aimee on her podcast and am very grateful for the helpful information you provide. I am 34 years old and have an almost 3-year old daughter… — Susanne S.
Dr. Geoffrey Sher answered
It is highly unlikely the the elevated aCL alone would lead to secondary recurrent pregnancy loss (RPL). I would venture an educated guess that there is a non-immunologic cause for implantation dysfunction (perhaps the integrity of the uterine cavity or a thin uterine lining). More likely however is…
Embryos & Genetic Testing
Hi- I have had 3 miscarriages in the last 15 months. First happened at 6 weeks. No heartbeat/questionable fetal pole. Second and third happened after strong heartbeat- measuring 9 weeks. Third was through IVF and was a PGT normal embryo.… — Kaitlin M.
Dr. Geoffrey Sher answered
When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost within 10 weeks of conception (in the…
Embryos & Genetic Testing
Hi, Why would I get pregnant naturally twice (ended in 6 week miscarriages) within 6 months, but have had 2 good quality pgt embryos fail to implant? Why would it implant naturally and not with IVF? Thanks — Laura P.
Dr. Geoffrey Sher answered
This sounds like implantation dysfunction. Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or…
