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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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226 answers

Embryos & Genetic Testing

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Egg Health & Ovarian Reserve Apr 11, 2023

Poor egg quality

Hello Dr Sher. I am a 34 yo F with spouse 43 yo M. G0P0, dx with unexplained infertility. BMI 22, no PMH and no male factors based on SA. Placed on levothyroxine during initial work up to bring TSH… — Aradhna S.

Dr. Geoffrey Sher answered

I think we should talk! Please consider calling my assistant, Patti Converse at 702-533-2691 and setting up an online consultation with me to discuss your case in detail.: One of the commonest questions asked by patients undergoing IVF relates to the likelihood of their eggs fertilizing and the…
Embryos & Genetic Testing Apr 7, 2023

immunological incompatibility

Dear Dr. Sher, Thank you very much for your prompt response. Maybe I should have told you a bit of my story. I am 37 years old and last year I had 3 abortions (week 7+5, week 5 and week… — Lis A.

Dr. Geoffrey Sher answered

Please contact my assistant Patti (702-533-2691) after the Easter weekend and set up an online consultation with me to discuss in detail. Geoff Sher
Embryos & Genetic Testing Apr 4, 2023

PGT-A

Hi Dr Sher Thank you for your answer to my previous question. I wanted to ask your opinion on PGT-A testing. A new study has cast doubts on the effectiveness of this testing: https://www.nytimes.com/2022/04/20/health/pgta-ivf-pregnancy-test.html And some doctors seems against it,… — Lisa-Marie E.

Dr. Geoffrey Sher answered

Human embryo development occurs through a process that encompasses reprogramming, sequential cleavage divisions and mitotic chromosome segregation and embryonic genome activation. Chromosomal abnormalities may arise during germ cell and/or preimplantation embryo development and represents a major cause of early pregnancy loss. About a decade ago, I and my…
Embryos & Genetic Testing Apr 3, 2023

Ivf

PGS tested Ivf failed — Amna S.

Dr. Geoffrey Sher answered

Embryo karyotype (as assessed by PGS/PGT) is a very important determinant of "competency" (the ability to propagate a viable pregnancy) but it is by no means the only factor! Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why!…
Embryos & Genetic Testing Mar 30, 2023

Monosomy

I have an embryo that has a monosomy but I would like to transfer it. I have had two clinics refuse to transfer. Specifically I have a 45 XX (-14) I figured it’s incompatible with life if results are accurate… — Charity H.

Dr. Geoffrey Sher answered

Human embryo development occurs through a process that encompasses reprogramming, sequential cleavage divisions and mitotic chromosome segregation and embryonic genome activation. Chromosomal abnormalities may arise during germ cell and/or preimplantation embryo development and represents a major cause of early pregnancy loss. About a decade ago, I and my…
Embryos & Genetic Testing Mar 24, 2023

One embryo or two to transfer in FET

Hello Dr. Sher, I am a 49 year old female with two miscarriages behind me. In both cases the embryos were found to be genetically abnormal. My husband and I have two genetically normally (tested) embryos from our younger days… — Mary W.

Dr. Geoffrey Sher answered

At 49-50y, you really do not want a multiple pregnancy...So I would advise transferring one at a timer. Good luck! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure:…
Egg Health & Ovarian Reserve Mar 23, 2023

IVF – Friend of Ivan Sher

Hello, I am 41 years old. I am a friend of Ivan Sher's for many years and he mentioned I could get some help from Dr. Sher on here. My AMH levels are 2.87. We started IVF when I was… — Mash P.

Dr. Geoffrey Sher answered

I am flattered that Ivan referred you to me and will do my best to advise. The response will be lengthy but please read it carefully: There are several issues that apply here 1, AGE: It is primarily the egg (rather than the sperm) that determines the chromosomal…
Embryos & Genetic Testing Mar 21, 2023

Should I continue to do egg retrievals or transfer?

Hi Dr Sher, I listened to you on The Egg Whisperer podcast. I found your way of explaining and just the overall wealth of knowledge you proved in just a couple of podcasts so incredibly helpful. Thank you for everting… — Danielle B.

Dr. Geoffrey Sher answered

Thank you for your communication. First , let me say that IUI in a woman over 40Y bis usually not a good idea. The baby rate is about 2-3% per cycle . And with diminished ovarian reserve (DOR), you do not have the time to waste on an…
Early Pregnancy & hCG Mar 18, 2023

Slow Rising hCG Levels for a Viable Pregnancy

Hi Dr Sher, I recently found out I'm pregnant with a chromosomally normal embryo and have had two Beta HCG tests, which have shown my levels are increasing as expected: First Beta HCG: 12 days past 6 day transfer =… — Mary T.

Dr. Geoffrey Sher answered

Very likely this will be a viable pregnancy (probably---80%+). Good luck! Geoffrey Sher Each and every patient/couple, in undergoing IVF makes huge emotional, physical and (in most cases) also financial investment. The fact that receiving the result of the blood human chorionic gonadotropin (hCG) pregnancy test represents the…
Embryos & Genetic Testing Mar 17, 2023

Do I Need Another Retrieval?

Dr. Sher, We got the following PGT tested embryos from our first round of IVF at 33: two 4aa, one 3aa, one 3ab, two 5bb (six total genetic normals out of 10 that made it to blast). One of the… — Mary P.

Dr. Geoffrey Sher answered

I would not test the "inconclusive" blastocyst. In my opinion, 2ndary testing is too traumatic on trhe embryo. I would also not do another ER. You had a good result and all things being equal (e.g., the absence of an implantation dysfunction) you should be able to ave…
Embryos & Genetic Testing Mar 14, 2023

Want to start accessing our oocytes or embryos

Need your support to access my ebryos by AI — Prashant S.

Dr. Geoffrey Sher answered

Not sure how to advise you! Sorry! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS)…
Early Pregnancy & hCG Mar 8, 2023

Vanishing twin from single embryo transfer – risks/prognosis?

Hello Dr. Sher, We transferred a single 5-day blastocyst January 30th. Our first hcg level was 1005 miu/ml at 14 days post-transfer, and 2nd hcg was 2200 miu/ml at 16 days. Two fetuses were present when we went in for… — Ian M.

Dr. Geoffrey Sher answered

In my opinion, the chance that the 2nd twin will be OK, is good! G-d bless and good luck! Geoff Sher
Embryos & Genetic Testing Mar 7, 2023

Repeated implantation failed

After having had several failed implantations of healthy embryos, I did blood tests and obtained very high values of Factor X activity, clothing, and Factor XII activity clothing. What does it mean and how does it affect me? What's the… — Sofia G.

Dr. Geoffrey Sher answered

I really don't think this is likely to be a problem. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with…
Embryos & Genetic Testing Mar 4, 2023

Aneuploid Embryos

Hello Dr Sher! I was wondering if any of these "aneuploid" embryos stand a chance? I was wondering if I could maybe implant any, and if yes can I implant more than one at a time? Thank you :) 1.… — Tina F.

Dr. Geoffrey Sher answered

If any are"mosaic" they could auto correct in the uterus. Discuss with your RE. EMBRYO MOSAICISM: WHAT IS IT AND WHAT ARE THE CONSEQUENCES? Geoffrey Sher MD Human embryo development occurs through a process that encompasses reprogramming, sequential cleavage divisions and mitotic chromosome segregation and embryonic genome activation.…
Embryos & Genetic Testing Feb 24, 2023

Recurrent Miscarriage

After four losses (ages 23, 32, and 33) I was diagnosed with one copy of PAI-1 and one copy of MTHFR. I also have very high thyroid antibodies. Could all of this be causing the losses? We are moving on… — Mary P.

Dr. Geoffrey Sher answered

I doubt that the heterozygous PAI-1 and one copy of MTHFR can explain the losses. the thyroid antibodies is however another matter ...see below. Geoff Sher Between 2% and 5% of women of the childbearing age have reduced thyroid hormone activity (hypothyroidism). Women with hypothyroidism often manifest with…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

226 answers

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