The question
Dear Dr. Sher,
Thank you very much for your prompt response. Maybe I should have told you a bit of my story. I am 37 years old and last year I had 3 abortions (week 7+5, week 5 and week 4). I am not diabetic, my TSH and free T4 are Ok, study of thrombophilia was negative (no mutations on Factor II Prothrombin 20210G>A and factor V Leiden R506), lupic anticoagulant negative, no phospholipid syndrome identified (anticardiolipin antibodies Ok), antithrombin test Ok, AMH 22.6 pmol/L, normal karyotype, uterus morphology is Ok, no microorganisms detected by PCR.
On February I did a first cycle of FIV + genetic testing of the embryo. They recovered 14 oocytes (10 mature), 6 had a normal fecundation by ICSI. The genetic testing revealed 3 euploid embryos and 2 aneuploid (the remaining embryo stopped growth from day 3 to 5). I was transferred a blastocyst 4A quality on day 5. Unfortunately, it did not work. That is why I wanted to do a KIR HLA-C test for me and my husband. The results just arrived (those I sent you in my previous message) but I cannot discern if they explain any possible incompatibility which might be the cause of the 3 abortions and the FIV implantation failure. For the next transfer, which will be in 2 weeks, I am already in treatment with daily aspirin 100mg and subcutaneous Clexane 40mg.
Do you have any recommendation of further tests/treatment?
Thank you very much
Answer from Dr. Geoffrey Sher
Please contact my assistant Patti (702-533-2691) after the Easter weekend and set up an online consultation with me to discuss in detail.
Geoff Sher
General information only, not medical advice for your own situation. For that, book a consultation.