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Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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178 answers

IVF Failure & Pregnancy Loss

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Egg Health & Ovarian Reserve Mar 15, 2023

3rd failed IVF and problem with egg maturity

Hello Dr Sher, First of all I would like to thank you in advance for giving me a chance to ask you a question and for answering if. I really appreciate it. I am 33 years old, have a good… — Stephanie K.

Dr. Geoffrey Sher answered

One of the commonest questions asked by patients undergoing IVF relates to the likelihood of their eggs fertilizing and the likely “quality of their embryos. This is also one of the most difficult questions to answer. On the one hand many factors that profoundly influence egg quality; such…
IVF Failure & Pregnancy Loss Mar 14, 2023

Failed ivf

I just failed my first round of IVF. I am 33. I have a 3 year old (spontaneous pregnancy). History of ulcerative colitis and j pouch with revision in 2018. My HSG was normal however given my previous gut history.… — Lindsey M.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
IVF Failure & Pregnancy Loss Mar 14, 2023

Gestational age with IVF

Hi, checking to see from what dae do you start counting IVF baby with a 5 day tranfer? I read where you add 2 weeks then, I read where you don't add 2 weeks. Then I read where you add… — Lela C.

Dr. Geoffrey Sher answered

You add 2 weeks + 5d. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS) “…
Embryos & Genetic Testing Mar 7, 2023

Repeated implantation failed

After having had several failed implantations of healthy embryos, I did blood tests and obtained very high values of Factor X activity, clothing, and Factor XII activity clothing. What does it mean and how does it affect me? What's the… — Sofia G.

Dr. Geoffrey Sher answered

I really don't think this is likely to be a problem. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with…
Immunology & Implantation Mar 6, 2023

High Foxp3 T-Cells

Hi Dr Sher, My Proliferative Phase Endometrium Immune Cell Studies on CD9 came back with Natural Killer Cells present at 5.1% and Foxp3 cells at 26/mm2. My fertility specialist has included in my next treatment plan for a FET for… — Katrina P.

Dr. Geoffrey Sher answered

I am sending you a copy of my book on immunology. You will see that I use a different approach for fixing on treatment. Geoff Sher Currently, with few exceptions, practitioners of assisted reproduction tend to attribute “unexplained and/or repeated” IVF failure(s), almost exclusively to poor embryo quality,…
IVF Failure & Pregnancy Loss Mar 4, 2023

Multiple IVF fails

Hi Dr. Sher thank you for your time. I’m 45 mother of 2 -18 &17 yr olds(normal pregnancies) I been doing IVF for the past 3 years. I’m currently on my 8th treatment with sperm & egg donor. I’ve had… — Ashley T.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
IVF Failure & Pregnancy Loss Feb 27, 2023

2 Implantation failure

I had 2 FET with 2 A grade embryo so each time but failed. No undying issues other than mild PCOS. chosen IVF due to male infertility low motility and 1% morphology. Please help me. I got the immunology tests… — Rakshitha R.

Dr. Geoffrey Sher answered

There are only t 4 Reproductive Immunology Labs in the US that in my opinion, can do the immune tests adequately. If these were not used, the results are probably erroneous. Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant…
Hormones & Ovulation Feb 26, 2023

IVF failure 1x

I just went through my 1st IVF transfer on 2/15/23, I have found out I failed. My uterus lining was 9+ , Embryo was 4AA. I am wondering if it’s my natural killer cells. I had Endometriosis and a Septate… — Marisa T.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
Embryos & Genetic Testing Feb 24, 2023

Recurrent Miscarriage

After four losses (ages 23, 32, and 33) I was diagnosed with one copy of PAI-1 and one copy of MTHFR. I also have very high thyroid antibodies. Could all of this be causing the losses? We are moving on… — Mary P.

Dr. Geoffrey Sher answered

I doubt that the heterozygous PAI-1 and one copy of MTHFR can explain the losses. the thyroid antibodies is however another matter ...see below. Geoff Sher Between 2% and 5% of women of the childbearing age have reduced thyroid hormone activity (hypothyroidism). Women with hypothyroidism often manifest with…
IVF Failure & Pregnancy Loss Feb 20, 2023

Ivf

Will m1 grade eggs fertilized? — Mahesh P.

Dr. Geoffrey Sher answered

Sometimes they do! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS) “ http://sherfertilitysolutions.com/sher-fertility-solutions-ebook.pdf “Recurrent Pregnancy…
Embryos & Genetic Testing Feb 16, 2023

Failed implantation

Hello, my husband and I have had a total of 6 good/top quality day 5 embryos implanted over the course of 2 years (2021- present). I have endometriosis, which I had surgery for in 2021. Following this surgery we had… — Ashley C.

Dr. Geoffrey Sher answered

Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or immunologic factors. IVF success rates…
Embryos & Genetic Testing Feb 14, 2023

Failed cycles

Hi, I learned of your clinic today on the egg whisperer and several questions arose from that video. I’ve had one retrieval with six day 5 embryos. My first fresh transfer failed with no implantation and my second was a… — Mary E.

Dr. Geoffrey Sher answered

There is a possibility that the hydrosalpinges could be playing a role here. However, it is important to also consider the possibility of an anatomical and/or immunologic implantation dysfunction. Please read below and then, if you are interested, contact my assistant Patti Converse (702-533-2691) and set up an…
IVF Failure & Pregnancy Loss Feb 13, 2023

Failed IVF Cycles

Hi Dr. Sher - I recently learned about you and your practice after listening to the Egg Whisperer Podcast. I've had two IVF cycles at two separate clinics in the Orlando, FL area. My first cycle resulted in 5 embryos,… — Ashley G.

Dr. Geoffrey Sher answered

Respectfully, This is likely NOT a lab issue but rather due to a combination of diminished ovarian reserve and the protocol used for ovarian stimulation. We should talk before you go any further. It is primarily the egg (rather than the sperm) that determines the chromosomal integrity (karyotype)…
Embryos & Genetic Testing Feb 9, 2023

Request for book download

Hi Dr. Sher, I am an IVF patient of Dr. Randall Loy (RE) at the Center for Reproductive Medicine in Winter Park, Florida. I am also a patient of Dr. Jubiz Giovanni (RI) in Kissimmee, Florida. After two losses and… — Michelle R.

Dr. Geoffrey Sher answered

ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS) “ http://sherfertilitysolutions.com/sher-fertility-solutions-ebook.pdf “Recurrent Pregnancy Loss and Unexplained IVF Failure:…
IVF Failure & Pregnancy Loss Jan 28, 2023

Yudy

Tengo ligadura de trompa y tengo 36 años podría reverser mis trompas ya que me gustaría tener otro bebe — Yudy D.

Dr. Geoffrey Sher answered

Please re-post in English! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS) “ http://sherfertilitysolutions.com/sher-fertility-solutions-ebook.pdf “Recurrent…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

178 answers

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