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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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178 answers

IVF Failure & Pregnancy Loss

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Embryos & Genetic Testing Jan 28, 2023

Follow up to last question- 3 miscarriages

Hi, to add on to my last question. 3 miscarriages (1 at 6 weeks before heartbeat, 2 measuring 9 weeks after strong heartbeat detected with one being a PGT normal embryo). The only thing that we have found is one… — Kaitlin M.

Dr. Geoffrey Sher answered

A heterozygous MTHFR mutation will in my opinion, not cause early pregnancy loss. When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30%…
Embryos & Genetic Testing Jan 28, 2023

Elevated Anticardiolipin

Hi Dr. Scher! I've been listening to a few of your interviews with Dr. Aimee on her podcast and am very grateful for the helpful information you provide. I am 34 years old and have an almost 3-year old daughter… — Susanne S.

Dr. Geoffrey Sher answered

It is highly unlikely the the elevated aCL alone would lead to secondary recurrent pregnancy loss (RPL). I would venture an educated guess that there is a non-immunologic cause for implantation dysfunction (perhaps the integrity of the uterine cavity or a thin uterine lining). More likely however is…
Embryos & Genetic Testing Jan 28, 2023

3 miscarriages

Hi- I have had 3 miscarriages in the last 15 months. First happened at 6 weeks. No heartbeat/questionable fetal pole. Second and third happened after strong heartbeat- measuring 9 weeks. Third was through IVF and was a PGT normal embryo.… — Kaitlin M.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost within 10 weeks of conception (in the…
Embryos & Genetic Testing Jan 22, 2023

Repeated Chemical Pregnancies

I have done 3 FETs with PGT-A tested euploid embryos. Results were 1 pregnancy that ended at 14.5 weeks due to genetic abnormalities, followed by 2 chemical pregnancies in the last 8 months. Since my 14.5 week loss, I have… — Alysa W.

Dr. Geoffrey Sher answered

RECURRENT PREGNANCY LOSS (RPL) Geoffrey Sher MD. When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost…
IVF Failure & Pregnancy Loss Jan 7, 2023

Mis

Necesito saber de la insiminaciom invitro Tengo 4 años intentando y quiero intentarlo de esa manera y quiero saber de los pagos como es — Madelyn G.

Dr. Geoffrey Sher answered

Please re post this question in English and I will respond promptly! ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher…
Embryos & Genetic Testing Dec 20, 2022

Dental bone graft before FET

Hi Dr.Sher, Thank you for taking the time to answer my question. A month prior to my FET I had dental bone graft placed. I took a full course of antibiotics and the healing was uneventful. Following month, my FET… — Ramya S.

Dr. Geoffrey Sher answered

The dental surgery and antibiotics would not have affected outcome. ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions…
IVF Failure & Pregnancy Loss Dec 19, 2022

Ivf

Hi my name is Sabrina I’m a mother of four boys . I have been on the Depo for 3 years I want to get off the Depo . We want a girl so bad but I’m afraid it will… — Sabrina T.

Dr. Geoffrey Sher answered

I strongly suggest you contact my assistant, Patti Converse at 702-533-2691 so we can discuss your options. In the meanwhile, please see below. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for…
Immunology & Implantation Dec 5, 2022

Miscarriage

I had a term baby at 38years. I was treated with immune protocol - Intralipid, clexane, dexamethasone,aspirin and so on for repeated implantation failure( after 6 failed implantation) Hla DQ and NK cells normal At 40 I did ivf again… — Ananthy A.

Dr. Geoffrey Sher answered

I am afraid , I would need a great deal more information to be able to comment authoritatively!. We should talk! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading…
Hormones & Ovulation Dec 2, 2022

Infertility/Recurrent loss

Hello Dr. Sher, Thank you for taking the time to answer my questions. I have 1 daughter (age 16) then loss my son at 23 weeks gestation 2 years later, had 3 ectopic pregnancies and 4 chemical pregnancies. I've had… — Janeé B.

Dr. Geoffrey Sher answered

Your underlying PCOS does not explain the losses (chemical or ectopic). You likely have an underlying secondary implantation dysfunction which could be an autoimmune and/or alloimmune, immunologic implantation dysfunction (IID). The presentation suggests that it possibly is more likely the latter. Endometriosis is associated with an IID in…
IVF Failure & Pregnancy Loss Nov 30, 2022

Recurrent Chemical Pregnancy

Hi Dr. Sher, I love listening to you and first discovered you on the Dr. Aimee show! Thank you for all you have done and do in this field! I am 37 years old with 2 LB's, AMH is 6.37mg/dl… — Crystal M.

Dr. Geoffrey Sher answered

Q1. How likely could the negative impacts of potential endometriosis, such as poorer egg quality have on RPL in my case? I don't have any endometriomas, good reserve, clear tubes etc. It seems that more studies link endometriosis to infertility vs. RPL, specifically chemical pregnancy? I'm concerned if…
Hormones & Ovulation Nov 25, 2022

2 IVF failures and 1 cancellation

I’m 36 (insulin resistant & subclinical hypothyroidism + DOR 4.0 pmol) I have been trying for 4.5 years, I have completed two ivf cycles (Gonal F 450 and Menopur 150) First ivf cycle with Testosterone gel, which resulted in 3… — Mychelle G.

Dr. Geoffrey Sher answered

There are several possible factors :Diminished ovarian reserve: Protocol selection for ovarian stimulation; Male factor; egg quality; implantation dysfunction (possibly related to an autoimmune, immunologic implantation dysfunction.(IID) such as Thyroid autoimmune disease and underlying ndometriosis. Obviously I cannot address all these here. I suggest we talk....SO, I invite…
Immunology & Implantation Nov 23, 2022

RIF and DE cycles

I have had 5 DE failed cycles. I’m Kir-Aa, I have Hashimotos, and I’ve been on Lovenox, Prednisone and Aspirin for the last 3 rounds and still failed despite high quality embryos. The donor was HLA. Now we can start… — Sophie W.

Dr. Geoffrey Sher answered

WE really should talk! To me it seams that there is an underlying implantation dysfunction that is likely immunologic in origin. If I am correct then respectfully, in my opinion, the treatment to address the immunologic implantation dysfunction (IID) was not optimal/adequate.I invite you to contact my assistant,…
Embryos & Genetic Testing Nov 23, 2022

32, 3 failed IUIs, 1 failed IVF transfer

Hi, I’m 32 years old and was diagnosed with mild endo which was removed last year. I’ve also had a few polyps, fibroids and cysts removed in the past 2 years. I had 3 failed IUIs and recently my first… — Miranda B.

Dr. Geoffrey Sher answered

I suggest we talk. Please consider calling Patti Converse (my assistant) at 702-533-2691 and set up an online consultation with me to discuss. When women with infertility due to endometriosis seek treatment, they are all too often advised to first try ovarian stimulation (ovulation Induction) with intrauterine insemination…
Immunology & Implantation Nov 23, 2022

Free immunology e-book link

Good afternoon, I recently heard your interview with Dr. Aimee (the Egg whisperer) about reoccurring implantation failure. My husband and I are seeing a fertility specialist in the Chicagoland area and we have gone through the gambit of miscarriage from… — Rachel P.

Dr. Geoffrey Sher answered

I really suspect an underlying implantation dysfunction...probably an immunologic implantation dysfunction. If I am correct, you were not (in my opinion) adequately treated. WE should talk!! Might I suggest that you contact my assistant, Patti Converse at 702-533-2691 and set up an online consultation with me. I believe…
Embryos & Genetic Testing Nov 14, 2022

steroids for raised TH1/TH2 assay

I had my first child with no difficulty. followed by 3 losses due to chromosomal issues then went to IVF and had 1 successful birth! We have been trying for the last 4 years and it has resulted in 2… — Tasnem A.

Dr. Geoffrey Sher answered

Your raised TH1: TH2 suggests activated uterine natural killer cells. In your case, having had a child already, this suggests that it is alloimmune rather than autoimmune, immunologic implantation dysfunction (IID). This would require a different approach to treatment. First, however you need to establish a diagnosis. We…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

178 answers

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