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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

  • Dear Patients,

    I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

    – Geoffrey Sher, MD

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Search 1,017 questions patients have already asked, or narrow them by topic.

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  1. Immunology & Implantation

    Probable cause of Infetility Immune Related

    Good day Dr Sher I hope you are well. My name is Candice Castle, I am a functional health practitioner and you assisted me years ago with what medication to import into South africa so that I could have a… — Candice C.

    Dr. Geoffrey Sher answered

    Dear Candice, Thank you for your kind sentiments. It is a pleasure and privilege to be of service. It certainly sounds as if your patient likely has an implantation dysfunction. Please advise her to read the information below carefully and to access the e-book attachments below for more…

  2. Immunology & Implantation

    Any Correlation between elevated NK cells and MCAS diagnosis?

    Hi Dr Sher, Thanks to you, I have an amazing 5 year old daughter named Amelia, from your last batch of IVF protocols in Las Vegas. Shes doing wonderful and really is our miracle baby. While undergoing treatment with you,… — Hilary U.

    Dr. Geoffrey Sher answered

    I wish I had an answer for you on this issue...but although I suspect there could be a link to autoimmune, IID , there is no data to support this.. There is however unlikely to be a link with alloimmune IID (DQ alpha/HLA matching/NKa+). Thanks for the kind…

  3. Immunology & Implantation

    RIF

    Hi there, We had a son nearly 5 years ago within a few months of trying (cesarian), since then we have had a blighted ovum, 1 chemical pregnancy, 1 6 week miscarriage trisomy 8, and 10 failed implantations (of high… — Sean T.

    Dr. Geoffrey Sher answered

    This sounds very much like an anatomical implantation dysfunction (see below). I suggest we talk. Please contact my assistant, Patti Converse at 702-533-2691 to set this up. Geoff Sher IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES. Implantation dysfunction is often overlooked as a…

  4. Immunology & Implantation

    Positive ANA

    Hi, I am ANA positive (as well as Smith (Sm) Ab, Sm RNP and Centromere B Ab Positive), I have had a chemical this year in March, a blighted ovum in June at 7 weeks, and then a MMC in… — Ashley A.

    Dr. Geoffrey Sher answered

    Thanks for connecting with me. I really think we should talk. Please read the material below and thereupon, call my assistant, Patti at 702-533-2691 and set up an online consultation with me to discuss! Geoff Sher IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES.…

  5. Immunology & Implantation

    Infertility

    Can you help me with infertility inmune issues — Susanna V.

    Dr. Geoffrey Sher answered

    Absolutely I can! Please call my assistant, Patti Converse (702-533-2691 or email her at concierge@sherfertility.com to set up an online consultation with me. Geoff Sher A RATIONAL BASIS FOR MANAGEMENT OF IMMUNOLOGIC CAUSES OF EMBRYO IMPLANTATION DYSFUNCTION In the world of assisted reproduction, when IVF fails repeatedly or…

  6. Immunology & Implantation

    Alloimmunity Question

    Hello Dr Sher. I received my fertilysis report stating that my husband and I are a full HLA-DQ match. I also have a moderately increased th1/th2 ratio. My NK cell cytotoxicity assay was normal. I have one living son followed… — Stephanie M.

    Dr. Geoffrey Sher answered

    Hard to say without direct access to your NK cell activity data in the Native state and to your and your partner's HLA/DQ alpha genotypes. I suggest you call my assistant, Patti (702-533-2691) and set up an online consultation to discuss. Also if you decide to do so,…

  7. Immunology & Implantation

    Autoimmune disorders

    Good evening, I have multiple poly glandular autoimmune disorders. Hashimotos, Addison, and fsh receptors are blocked so I never get a period anymore. I had a successful egg retrieval but had to be on high dose prednisone for my body… — Mallory L.

    Dr. Geoffrey Sher answered

    _ Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF…

  8. Embryos & Genetic Testing

    Treatment for immune issues and euploid RPL

    Hello, I am a 32 y/o in Canada with history of 3 euploid miscarriages. First pregnancy embryo stopped growing 6.5 weeks, second pregnancy was a MMC of a blighted ovum, third pregnancy mono/mono twins resulted from a single embryo, both… — Anastasia S.

    Dr. Geoffrey Sher answered

    Respectfully, your immunologic implantation dysfunction is likely due to an alloimmune cause and if so would require different treatment (see below and read the E-books presented below ). I suggest you call my assistant, Patti Converse and set up an online consultation with me to discuss your case…

  9. Immunology & Implantation

    Pregnancy Loss, IVF & Immunologic Testing

    Hi Dr. Sher, I live in Toronto and have had 2 chemicals and one miscarriage within the span of 5 months. I used Letrozole to ovulate with the first 2 pregnancies, but I ovulated naturally with the third pregnancy. For… — Catherine B.

    Dr. Geoffrey Sher answered

    Based upon your representation, this sounds very suggestive of an embryo implantation dysfunction.However, to provide an authoritative opinion we should talk. If I turn out to be correct and you are not treated appropriately to counter the implantation dysfunction, you will very likely experience the same over and…

  10. Immunology & Implantation

    Immune Testing

    I am 37 yo with dx of DOR. Have banked 7 PGTa normal embryos via 3 retrievals. 4 medicated FET (on dexamethasone, ASA 81mg, intralipids 1 week prior to transfer) resulted in chemical pregnancies. Question now on possible immune/ alloimmune… — Is S.

    Dr. Geoffrey Sher answered

    Thanks for the communication. You really need a comprehensive autoimmune/alloimmune, immunologic implantation dysfunction (IID) evaluation done. WE really should interact online. I recommend that you call my assistant, Patti Converse (702-533-2691) and set up a consultation with me discuss. In the interim, please see below: >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> Implantation dysfunction…

  11. Early Pregnancy & hCG

    Abnormal placentation and immune pr

    Hi Dr. Sher, I've gone through 2 egg retrievals and 5 fets, gotten pregnant twice and had 2 miscarriages in the last year and a half. The miscarriage last year at 6 weeks happened at home and I had a… — Bethany D.

    Dr. Geoffrey Sher answered

    It is very likely that your issues center around implantation dysfunction. I need more information to provide an authoritative opinion. I suggest you contact my assistant, Patti Converse at 702-533-2691 and set up an online consultation with me to discuss your case in detail. In the interim, please…

  12. Immunology & Implantation

    Failed ivf with donor eggs

    Dear Dr Sher I’m 50 year old , I have healthy 9 year old boy from my first marriage, with my second marriage my husband is 55 yrs old , tried one cycle ivf with 2 healthy embryos-my won eggs-… — Fofo A.

    Dr. Geoffrey Sher answered

    This sounds like a possible implantation dysfunction. I suggest we talk. Please contact my assistant, Patti Converse (702-533-2691) and set up an online consultation with me to discuss in depth. IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES. Implantation dysfunction is often overlooked as…

  13. Immunology & Implantation

    IVF and Immunity

    Dear Dr. Sher and Dr. Tortoriello, I am 38 years old and my husband and I are in the 5th year of our fertility journey. I conceived naturally in 2019 and 2021, both missed ab, we tried several rounds of… — Susanne S.

    Dr. Geoffrey Sher answered

    I aplaud your looking in to immunologic implantation dysfunction (IID) as a possible reason for your losses. If you indeed do have an autoimmune/alloimmune IID link It might not have been comprehensively assessed. There are only a hand-full of laboratories in the world that can do the required…

  14. Hormones & Ovulation

    Repeated Miscarriages

    Hi, My husband and I have been trying to conceive for 2 years now and have had 6 miscarriages within that time, all being early miscarriages except for our little girl who stopped growing at 13 weeks due to triploidy.… — Breann W.

    Dr. Geoffrey Sher answered

    _ When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent…

  15. Egg Health & Ovarian Reserve

    Ivf low responder

    Aldingen some additional information I forgot in my initial question: - no problems with uterine thickness and according to my doctor no signs of any scarves as due to thickness of approx 9-10 mm few days before ovulation - during… — Sandra W.

    Dr. Geoffrey Sher answered

    In my opinion, we should talk. I cannot provide authoritative advice on this information alone. I suggest you call my assistant, Patti Converse (702-533-2691) and set up an online consultation with me to discuss in detail. Geoff Sher ADDRESSING DIMINISHING OVARIAN RESERVE (DOR) IN IVF Understanding the impact…

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