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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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137 answers

Immunology & Implantation

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Immunology & Implantation Jan 11, 2025

Any Correlation between elevated NK cells and MCAS diagnosis?

Hi Dr Sher, Thanks to you, I have an amazing 5 year old daughter named Amelia, from your last batch of IVF protocols in Las Vegas. Shes doing wonderful and really is our miracle baby. While undergoing treatment with you,… — Hilary U.

Dr. Geoffrey Sher answered

I wish I had an answer for you on this issue...but although I suspect there could be a link to autoimmune, IID , there is no data to support this.. There is however unlikely to be a link with alloimmune IID (DQ alpha/HLA matching/NKa+). Thanks for the kind…
Immunology & Implantation Nov 11, 2024

RIF

Hi there, We had a son nearly 5 years ago within a few months of trying (cesarian), since then we have had a blighted ovum, 1 chemical pregnancy, 1 6 week miscarriage trisomy 8, and 10 failed implantations (of high… — Sean T.

Dr. Geoffrey Sher answered

This sounds very much like an anatomical implantation dysfunction (see below). I suggest we talk. Please contact my assistant, Patti Converse at 702-533-2691 to set this up. Geoff Sher IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES. Implantation dysfunction is often overlooked as a…
Immunology & Implantation Nov 5, 2024

Positive ANA

Hi, I am ANA positive (as well as Smith (Sm) Ab, Sm RNP and Centromere B Ab Positive), I have had a chemical this year in March, a blighted ovum in June at 7 weeks, and then a MMC in… — Ashley A.

Dr. Geoffrey Sher answered

Thanks for connecting with me. I really think we should talk. Please read the material below and thereupon, call my assistant, Patti at 702-533-2691 and set up an online consultation with me to discuss! Geoff Sher IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES.…
Immunology & Implantation Oct 18, 2024

Infertility

Can you help me with infertility inmune issues — Susanna V.

Dr. Geoffrey Sher answered

Absolutely I can! Please call my assistant, Patti Converse (702-533-2691 or email her at concierge@sherfertility.com to set up an online consultation with me. Geoff Sher A RATIONAL BASIS FOR MANAGEMENT OF IMMUNOLOGIC CAUSES OF EMBRYO IMPLANTATION DYSFUNCTION In the world of assisted reproduction, when IVF fails repeatedly or…
Immunology & Implantation Sep 24, 2024

Alloimmunity Question

Hello Dr Sher. I received my fertilysis report stating that my husband and I are a full HLA-DQ match. I also have a moderately increased th1/th2 ratio. My NK cell cytotoxicity assay was normal. I have one living son followed… — Stephanie M.

Dr. Geoffrey Sher answered

Hard to say without direct access to your NK cell activity data in the Native state and to your and your partner's HLA/DQ alpha genotypes. I suggest you call my assistant, Patti (702-533-2691) and set up an online consultation to discuss. Also if you decide to do so,…
Immunology & Implantation Sep 11, 2024

Autoimmune disorders

Good evening, I have multiple poly glandular autoimmune disorders. Hashimotos, Addison, and fsh receptors are blocked so I never get a period anymore. I had a successful egg retrieval but had to be on high dose prednisone for my body… — Mallory L.

Dr. Geoffrey Sher answered

_ Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF…
Embryos & Genetic Testing Sep 4, 2024

Treatment for immune issues and euploid RPL

Hello, I am a 32 y/o in Canada with history of 3 euploid miscarriages. First pregnancy embryo stopped growing 6.5 weeks, second pregnancy was a MMC of a blighted ovum, third pregnancy mono/mono twins resulted from a single embryo, both… — Anastasia S.

Dr. Geoffrey Sher answered

Respectfully, your immunologic implantation dysfunction is likely due to an alloimmune cause and if so would require different treatment (see below and read the E-books presented below ). I suggest you call my assistant, Patti Converse and set up an online consultation with me to discuss your case…
Immunology & Implantation Aug 19, 2024

Pregnancy Loss, IVF & Immunologic Testing

Hi Dr. Sher, I live in Toronto and have had 2 chemicals and one miscarriage within the span of 5 months. I used Letrozole to ovulate with the first 2 pregnancies, but I ovulated naturally with the third pregnancy. For… — Catherine B.

Dr. Geoffrey Sher answered

Based upon your representation, this sounds very suggestive of an embryo implantation dysfunction.However, to provide an authoritative opinion we should talk. If I turn out to be correct and you are not treated appropriately to counter the implantation dysfunction, you will very likely experience the same over and…
Immunology & Implantation Aug 15, 2024

Immune Testing

I am 37 yo with dx of DOR. Have banked 7 PGTa normal embryos via 3 retrievals. 4 medicated FET (on dexamethasone, ASA 81mg, intralipids 1 week prior to transfer) resulted in chemical pregnancies. Question now on possible immune/ alloimmune… — Is S.

Dr. Geoffrey Sher answered

Thanks for the communication. You really need a comprehensive autoimmune/alloimmune, immunologic implantation dysfunction (IID) evaluation done. WE really should interact online. I recommend that you call my assistant, Patti Converse (702-533-2691) and set up a consultation with me discuss. In the interim, please see below: >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> Implantation dysfunction…
Early Pregnancy & hCG Aug 12, 2024

Abnormal placentation and immune pr

Hi Dr. Sher, I've gone through 2 egg retrievals and 5 fets, gotten pregnant twice and had 2 miscarriages in the last year and a half. The miscarriage last year at 6 weeks happened at home and I had a… — Bethany D.

Dr. Geoffrey Sher answered

It is very likely that your issues center around implantation dysfunction. I need more information to provide an authoritative opinion. I suggest you contact my assistant, Patti Converse at 702-533-2691 and set up an online consultation with me to discuss your case in detail. In the interim, please…
Immunology & Implantation Aug 7, 2024

Failed ivf with donor eggs

Dear Dr Sher I’m 50 year old , I have healthy 9 year old boy from my first marriage, with my second marriage my husband is 55 yrs old , tried one cycle ivf with 2 healthy embryos-my won eggs-… — Fofo A.

Dr. Geoffrey Sher answered

This sounds like a possible implantation dysfunction. I suggest we talk. Please contact my assistant, Patti Converse (702-533-2691) and set up an online consultation with me to discuss in depth. IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES. Implantation dysfunction is often overlooked as…
Immunology & Implantation Aug 5, 2024

IVF and Immunity

Dear Dr. Sher and Dr. Tortoriello, I am 38 years old and my husband and I are in the 5th year of our fertility journey. I conceived naturally in 2019 and 2021, both missed ab, we tried several rounds of… — Susanne S.

Dr. Geoffrey Sher answered

I aplaud your looking in to immunologic implantation dysfunction (IID) as a possible reason for your losses. If you indeed do have an autoimmune/alloimmune IID link It might not have been comprehensively assessed. There are only a hand-full of laboratories in the world that can do the required…
Hormones & Ovulation Aug 5, 2024

Repeated Miscarriages

Hi, My husband and I have been trying to conceive for 2 years now and have had 6 miscarriages within that time, all being early miscarriages except for our little girl who stopped growing at 13 weeks due to triploidy.… — Breann W.

Dr. Geoffrey Sher answered

_ When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent…
Egg Health & Ovarian Reserve Jul 22, 2024

Ivf low responder

Aldingen some additional information I forgot in my initial question: - no problems with uterine thickness and according to my doctor no signs of any scarves as due to thickness of approx 9-10 mm few days before ovulation - during… — Sandra W.

Dr. Geoffrey Sher answered

In my opinion, we should talk. I cannot provide authoritative advice on this information alone. I suggest you call my assistant, Patti Converse (702-533-2691) and set up an online consultation with me to discuss in detail. Geoff Sher ADDRESSING DIMINISHING OVARIAN RESERVE (DOR) IN IVF Understanding the impact…
Embryos & Genetic Testing Jul 17, 2024

AMA and RPL (Secondary Infertility) – Chemical after First FET

I just found out my first FET with a PGT-A tested 6AA embryo is ending in a chemical. I'm 35 with 2 known autoimmune issues (vitiligo and Reynaud's) and a history of RPL (2 miscarriages, at 7 and 8 weeks).… — Jillian B.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent pregnancy…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

137 answers

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