Dr. Geoffrey Sher

Hormonal Treatment of Male Infertility

There exists in the man a cyclical production of spermatozoa where
the duration of spermatogenesis from takes approximately 90 days. It
follows that, any treatment aimed at enhancing sperm production
requires approximately a period of 3 months. Since the enhancement of
testicular function must of necessity be mediated through FSH and LH 
it follows that in order to assess response to testicular stimulatory
drugs it is necessary to get a baseline FSH, LH and testosterone as
well as a semen…

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Cyclical Estrogen Therapy Prior to Embryo Transfer, in Post-Menopausal Women and those with Prolonged Hypothalamic Amenorrhea, Can Reduce the Chance of Failed IVF and Miscarriage

 
An absence of menstruation (amenorrhea) in reproductive age women is
usually due to an absence of ovulation (anovulation). If this becomes
prolonged, then these women are at risk for the ill effects associated
from chronically low estrogen levels (hypoestrogenemia).  
Specifically, the women at risk for this would be those experiencing
premature ovarian failure (early menopause) or hypothalamic
amenorrhea. Whatever the cause, hypoestrogenemia will eventually lead
to a shrinkin…

Cyclical Estrogen Therapy Prior to Embryo Transfer, in Post-Menopausal Women and those with Prolonged Hypothalamic Amenorrhea, Can Reduce the Chance of Failed IVF and Miscarriage Read More »

The Role of IVF in the Management of Infertility Caused by Pelvic Inflammation

Pelvic Inflammatory Disease (PID) refers to inflammation of pelvic
structures including the uterus, fallopian tubes
[/blog/role-ivf-cases-tubal-damage/], ovaries, bowel, and the smooth
membrane that lines the surface of the pelvic cavity (the peritoneum).
PID
[/blog/pelvic-inflammatory-disease-pid-tubal-damage-hydrosalpinx-preparing-ivf/]
follows inf…

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Case Report: Can Intralipid/Steroid Therapy be Used Without Undergoing IVF?

_Question posed by by Patient X: _ Can oral steroids (prednisone) and
IL therapy be done without IVF? I have had 2 failed IUI’s 2 years
ago, but I do not like taking ovulation stimulating hormones. I have
endometriosis (not sure of what stage), am not currently working with
an RE, and have been TTC for 6 years. I have a higher than normal for
TTC TSH level (3.5-4), am 34Y/O, totally normal and regular periods
with ovulation almost every month, and husband checks out with good
numbe…

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The Number of Embryos/Blastocysts Transferred & PGT: Effect on IVF Outcome:

A “competent” embryo is one that is chromosomally, genetically and
metabolically capable of propagating a viable conceptus in-utero. Such
an embryo will have the same chance of resulting in a baby whether it
is transferred cleaved( on day 2,3,4) or as a blastocyst (day 5 or 6),
post-fertilization. Currently, we have no ability to reliably assess
the genetic and metabolic integrity of an embryo. The only tools we
currently have to rely on are: a) the embryo’s microscopic
appearance …

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Case Report: Egg Donation-Mother Uses her Daughter’s Eggs to conceive

The case involves D.R, a recently remarried, premenopausal woman in
her late 40’s, who had a daughter (N.R.) some 33Y ago, in a prior
marriage. D.R. inquired whether I would be willing to do IVF on her
daughter, fertilize the eggs with her husband’s sperm and then
transfer the embryos to her (DR’s) uterus. Needless to say, it was
recognized that if successful, and D.R. were to give birth to a baby
born from NR’s eggs, she would be giving birth to her own genetic
grandchild who wo…

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Case Report: The Diagnosis of “Unexplained” Recurrent IVF-Failure is Sometimes a Cop-out

Ingrid (37y) and Jesse 41y had been trying to conceive for 6 years.
The couple was “thoroughly tested” and had been “labeled” as
having _“unexplained infertility”._ Ingrid had patent fallopian
tubes, a normal (regular) uterine cavity, was experiencing regular and
normal menstrual cycles and her ovulation was found to be normal with
adequate supporting hormonal environment. Jesse had normal sperm
parameters and had in fact initiated a pregnancy in a previous
relationship,…

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