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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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Page 58 of 68

Immunology & Implantation Jan 28, 2023

High NK Cells & using donor egg

Hello Dr Sher, I have elevated NK cells and even after completing a full immune protocol (ivig, intrallipids) my NK cells went from 15.6 down to 14.9. My husband and I have a full DQ alpha match and no matter… — Melissa K.

Dr. Geoffrey Sher answered

In my opinion...you would face the same issues . It is not recommended! This is about your genotype and that of the sperm that fertilized the egg. It is not about egg and sperm. Read the additional information below! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links…
Embryos & Genetic Testing Jan 28, 2023

3 miscarriages

Hi- I have had 3 miscarriages in the last 15 months. First happened at 6 weeks. No heartbeat/questionable fetal pole. Second and third happened after strong heartbeat- measuring 9 weeks. Third was through IVF and was a PGT normal embryo.… — Kaitlin M.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost within 10 weeks of conception (in the…
Embryos & Genetic Testing Jan 22, 2023

PGT embryos no implantation

Hi, Why would I get pregnant naturally twice (ended in 6 week miscarriages) within 6 months, but have had 2 good quality pgt embryos fail to implant? Why would it implant naturally and not with IVF? Thanks — Laura P.

Dr. Geoffrey Sher answered

This sounds like implantation dysfunction. Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or…
Ovarian Stimulation & OHSS Jan 22, 2023

Stimulation protocol

Good morning Dr. Sher. Hope this message finds you well and that you can provide me with some insight. We have MFI with my husband’s sperm having 0% morphology, borderline low motility (0% fast A progressive swimmers and 26-28% slow… — Nakia O.

Dr. Geoffrey Sher answered

That sounds like a reasonable approach! I wish you well! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher…
Embryos & Genetic Testing Jan 22, 2023

Repeated Chemical Pregnancies

I have done 3 FETs with PGT-A tested euploid embryos. Results were 1 pregnancy that ended at 14.5 weeks due to genetic abnormalities, followed by 2 chemical pregnancies in the last 8 months. Since my 14.5 week loss, I have… — Alysa W.

Dr. Geoffrey Sher answered

RECURRENT PREGNANCY LOSS (RPL) Geoffrey Sher MD. When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost…
Hormones & Ovulation Jan 19, 2023

Trigger using HCG10,000 and Decapeptyl

Hi Dr Sher, my RE has asked me to trigger with both HCG 10,000 and Decapeptyl 1 ml. I find this strange. I understand that Dual Trigger is considered for cases where there might be risk of OHSS, but I… — Jenna H.

Dr. Geoffrey Sher answered

Respectfully, I do agree with you, but this is something you need to discuss with your treating RE “Triggering” Egg Maturation in IVF: Comparing urine-derived hCG, Recombinant DNA-hCG and GnRH-agonist: Geoffrey Sher MD Ideal egg development sets the scene for optimal egg maturation that occurs 36-42h prior to…
Hormones & Ovulation Jan 18, 2023

Dropping LH Levels, no ovulation yet but growing follicles

Hi Dr. I am undergoing a few rounds of cycle monitoring with medicated timed intercourse while I wait for my turn for funded IVF ( I live in Canada). I took Letrozole on days 2-6 of my cycle and went… — Jackie B.

Dr. Geoffrey Sher answered

Letrozole increases blood LH. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS) “ http://sherfertilitysolutions.com/sher-fertility-solutions-ebook.pdf “Recurrent…
Embryos & Genetic Testing Jan 18, 2023

Day 7 embryo

Hello doc. Our last euploid embryo is day 7 cc grade. We’re not very optimistic to be honest. What are the success rates of day 7 embryos? I have read some mixed data. I was 29 at time of egg… — A. A.

Dr. Geoffrey Sher answered

Respectfully, the success rate with day-7 blastocysts is very poor...even if it is assessed as being euploid Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro…
Embryos & Genetic Testing Jan 17, 2023

Implantation testing

Hi Dr Sher, I hope all is well. I just received my results for implantation tests and I was told that my vaginal microbiome was "low" - good bacteria content was low. The advice to do not do anything, just… — Cassidy O.

Dr. Geoffrey Sher answered

I do not believe in Microbiome testing. Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium)…
Third-Party Reproduction Jan 15, 2023

Possible IVF egg donor and success for patients who have Adenomyosis and Endometriosis

Hi We are based in the UK and want to know your live birth success rates for patients using egg donor, with a diagnosis of Adenomyosis and Endometriosis. I am also age 47 yrs and understand that there are risks… — Fiona F.

Dr. Geoffrey Sher answered

Adenomyosis-Related Infertility: A Therapeutic Challenge! Geoffrey Sher MD Adenomyosis is a condition where endometrial glands develop outside the uterine lining (endometrium), within the muscular wall of the uterus (myometrium). Definitive diagnosis of adenomyosis is difficult to make. The condition should be suspected when a premenopausal woman (usually>25 years…
Jan 15, 2023

Pregnitude

Hello, is the dietary supplement Pregnitude a good supplement to take to help conceive? It contains Folic acid 200mg and mayo-inositol 2000mg. Thank you — Julie A.

Dr. Geoffrey Sher answered

Seems OK to me. Geoff Sher
Age & Fertility Jan 15, 2023

IVF pregnancy age limit?

Dear Dr. Sher, I’d like to know if you have an age limit for assisting a post-menopausal woman to get pregnant with IVF? 50, 55, 60, 65 .. ? Thank you, ~Beth — Beth R.

Dr. Geoffrey Sher answered

Our cut off using own eggs is 47y. In my opinion doing IVF with own eggs over 43y is not wise. However, there is no definitive cut-off when donor eggs are used. I believe this very much depends on the health of the individual patient. Geoff Sher ADDITIONAL…
Uterine & Endometrial Health Jan 15, 2023

Plan for a Receptiva

Hi I’m currently under the care of a Boston clinic (reside in Bermuda). I am considering transferring clinics and location but have one remaining embryo to transfer. Before doing so I would like a receptiva test carrying out for endometriosis.… — Gemma W.

Dr. Geoffrey Sher answered

It should not present a problem, in my opinion. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility…
Jan 15, 2023

Pregnitude reviews

Hello, is the dietary supplement Pregnitude a good supplement to take to help conceive? It contains Folic acid 200mg and mayo-inositol 2000mg. Thank you. — Julie A.

Dr. Geoffrey Sher answered

Yes! It is a good supplement in my opinion. GS The Role of Nutritional Supplements in Preparing for IVF Geoffrey Sher MD It is important to nurture and take care of yourself mentally and physically when preparing and going through your IVF journey. This starts with trying to…
Egg Health & Ovarian Reserve Jan 12, 2023

Low AFC in IVF cycle after BCP vs IUI

Hi Dr Sher, I’ve done 5 IUIs before and my AFC has varied between 13 and 18. I’m now doing IVF. After 13 days of taking BCP, my ultrasound only showed 9 follicles and I was asked to start stims.… — Sophie J.

Dr. Geoffrey Sher answered

I would not take this AFC count as an accurate indication of how many follicles you might end up with. I suspect that with stimulation there will likely be more. Good luck! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

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