– Geoffrey Sher, MD
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Embryos & Genetic Testing
Hello, I compared the markers of different HLA genes between myself and my husband from our raw genetic data which was produced by 23andMe and I found the following: 1. HLA-A: 3/3 markers matched = 100% 2. HLA-B: 2/4 markers… — Holly S.
Dr. Geoffrey Sher answered
This is too complex for me to respond to authoritatively here. I request that you call my assistant, Patti Converse (702-533-2691) and set up an online consultation with me to discuss. Geoff Sher
Embryos & Genetic Testing
Dear Dr. Sher, Im 37 years old with long story of 15 natural chemical pregnancies and after one ovarian stimulation with my oen eggs but with no blastocysts in October 2023 I decided to go through frozen donor eggs from… — Ola C.
Dr. Geoffrey Sher answered
I think we should talk. Please call my assistant, Patti Converse (702-533-2691) and set up an online consultation with me to discuss in depth. UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other mammals. A significant number…
Embryos & Genetic Testing
Hi Dr Sher, Could you please try and answer what could be causing my issue and possible solution. I am 38 (husband 40) and we are married for 13 years; trying for a child since 10 years. I never had… — Indira V.
Dr. Geoffrey Sher answered
When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent pregnancy…
Embryos & Genetic Testing
I was sexually active march 4th and had unprotected sex… no seman got inside of me.i tested myself on the 18 got a negative and than got my embryo transfer on the 18 tested myself on the 19,20,21 Got a… — Jaylin W.
Dr. Geoffrey Sher answered
You tested too early! I suggest you test again now. That will give a more definitive result! Geoff Sher
Embryos & Genetic Testing
Hello Dr. Sher, I just watched a video of your interview with Dr. Aimee regarding RIF. I am age 36 with 5 failed to implant IUI's and 2 IVF retrievals with donor sperm. Prior to now I never tried to… — Michelle D.
Dr. Geoffrey Sher answered
ADDRESSING DIMINISHING OVARIAN RESERVE (DOR) IN IVF Understanding the impact of ovarian reserve on the success of in vitro fertilization (IVF) is crucial when it comes to reproductive health. This article aims to simplify and clarify these concepts, emphasizing their significance in the selection of ovarian stimulation protocols…
Embryos & Genetic Testing
Dear Dr. Sher, I am 43 years old, and due to the high rate of aneuploidy in the previous two attempts, and following your teachings, I convinced my doctor not to use Decapeptyl in the dual trigger, but only Ovidrel… — Anne C.
Dr. Geoffrey Sher answered
I really cannot suggest how to approach your doctor on this matter! So sorry! Geoff Sher
Embryos & Genetic Testing
Hello Dr. Sher at my current clinic I have gone through 4 transfers with PGT-A normal embryos. My first transfer resulted in a chemical pregnancy, but the following transfers did not implant at all. The tests I have done are… — Ashley P.
Dr. Geoffrey Sher answered
In my opinion this is almost certainly an implantation dysfunction. Bear in mind that in 30% of cases, endometriosis is associated with an immunologic implantation dysfunction. Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or…
Embryos & Genetic Testing
Hi there, I hope you are well. I had failed pgs tested 3AA embryo donation. Era receptive microbiom recently tested lactobacillus — Private
Dr. Geoffrey Sher answered
Understanding the impact of age and ovarian reserve on the success of in vitro fertilization (IVF) is crucial when it comes to reproductive health. This article aims to simplify and clarify these concepts, emphasizing their significance in the selection of ovarian stimulation protocols for IVF. By providing you…
Egg Health & Ovarian Reserve
1.3, 2.1cm Trigger was 10000 IU Gonasi HP (hCG) and on day 11. Only 1 mature egg was retrieved, and fertilised using ICSI. My day 3 update is a slow growing embryo of 3 cells with some fragmentation. I don't… — Vessie V.
Dr. Geoffrey Sher answered
"Empowering Choices: Embryo Banking vs. Egg Banking for Fertility Preservation" It's crucial for women to make informed decisions about preserving their fertility. Delaying trying to conceive, relying on egg freezing, or assuming the biological clock can be paused are misconceptions. As women age, egg quality declines, affecting the…
Embryos & Genetic Testing
What is the recommended transfer protocol for someone with high TNF Alpha. I was given prednisone but it did not work. Prior to transfer it was 45.0 and I was prescribed 25mg prednisone for a month but it increased to… — Private
Dr. Geoffrey Sher answered
Elevated TNF alpha indicates activated natural killer cell activity. A RATIONAL BASIS FOR MANAGEMENT OF IMMUNOLOGIC CAUSES OF EMBRYO IMPLANTATION DYSFUNCTION In the world of assisted reproduction, when IVF fails repeatedly or without explanation, it's often assumed that poor embryo quality is the main culprit. However, this view…
Embryos & Genetic Testing
My first FET in 2020 was successful and resulted in the birth of my son. Since 2022, I have had four more FETs: the first one failed to implant and the next three implanted but miscarried between 5-6 weeks. The… — Kelsey H.
Dr. Geoffrey Sher answered
Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success…
Embryos & Genetic Testing
I hope you can advise me on the situation below. I had Pregmune testing completed in January 2023. It showed my husband and I have DQ alpha match: DQ Alpha - full match, DQ Beta - partial match, HLA-DRB1 -… — Vilma C.
Dr. Geoffrey Sher answered
From your description, it certainly sounds as if your failures are due to an implantation dysfunction...likely, an immunologic implantation dysfrunction (IID). If so, then you MUST have a concommitant natural killer cell activation (NKa). Even though endometriosis can result in an autoimmune IID, and a matchibng D alpha…
Embryos & Genetic Testing
Hi! I’am 42 and I did the first stimulation for IVF. I obtained 2 embryos that I tested. I don't know what this result means, are they viable? Which one is good? First has these anomalies +8p, +12, +22, the… — Ioana I.
Dr. Geoffrey Sher answered
In my opinion, they are not viable! Geoff Sher
Embryos & Genetic Testing
Hi Dr Sher. I had an embryo transfer last Saturday. I rested for 2 days and then went back to the gym on Monday and Tuesday and exercised as normal. This includes weightlifting. I have however been reading that lifting… — Natalie S.
Dr. Geoffrey Sher answered
Exercising is not harmful BUT it is not wise to push yourself with over-demanding effort until a diagnosis of pregnancy can be made.Hopefully no harm was done! Good luck! Geoff Sher
Egg Health & Ovarian Reserve
Hello Dr. Sher, I just had an egg retrieval cycle where despite my follicles growing nicely and the clinic expecting to collect 15 eggs, they only retrieved 6 eggs, two of which have fertilised. Apparently, the ‘empty’ follicles contained cumulus… — Ruth A.
Dr. Geoffrey Sher answered
Empty Follicle Syndrome" is a misleading term because follicles always contain eggs. However, some eggs may have difficulties detaching and being retrieved. This is more likely to happen when multiple attempts are needed to retrieve an egg from a follicle, indicating the egg may have chromosomal abnormalities. The…
