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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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159 answers

Egg Health & Ovarian Reserve

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Egg Health & Ovarian Reserve Oct 1, 2024

Too many immature eggs

My daughter just completed her 2nd round of IVF. The first round yielded 7 out of 9 mature eggs but only one good blastocyst. This round yielded 14 eggs, and only 2 were mature. Only one of those fertilized &… — Eileen H.

Dr. Geoffrey Sher answered

Embarking on the journey of IVF often raises questions about the likelihood of success and the quality of embryos. While it’s challenging to predict outcomes due to various factors, there’s hope and information to guide you. Firstly, the key to fertilization potential lies in the chromosomal integrity of…
Egg Health & Ovarian Reserve Sep 30, 2024

Bad quality eggs

Dear Dr. Sher. I am out of options i feel. Unknown fertility problem, endometriosis. I am now 30 years old. For the last 5 years: 5 IVF/ICSI cycles, 65 mature eggs, 30 fertilized, 0 good blastocyst, only poor quality, nothing… — Maggy M.

Dr. Geoffrey Sher answered

Embarking on the journey of IVF often raises questions about the likelihood of success and the quality of embryos. While it’s challenging to predict outcomes due to various factors, there’s hope and information to guide you. Firstly, the key to fertilization potential lies in the chromosomal integrity of…
Egg Health & Ovarian Reserve Sep 30, 2024

It’s over

Dear Dr. Sher, I am 43 years old, and in the last 2 years: 6 cycles, 100 follicles, 90 oocytes collected, 60 oocytes matured, 50 embryos, 10 blastocytes, 1 euploid. One abortion (prior to ivf), two failed transfers (the euploid… — Anne C.

Dr. Geoffrey Sher answered

I think we should talk first before you make that determination definitively. If you are interested in having an online consultation with me, please contact my assistant, Patti Converse at 702-533-2691 or email her at concierge@sherivf.com\ Geoff Sher ADDRESSING ADVANCING AGE AND DIMINISHING OVARIAN RESERVE (DOR) IN IVF…
Egg Health & Ovarian Reserve Sep 19, 2024

poor egg quality

Im 37F no other medical history. AMH 2.01, Day 3 FSH 5.7, estradiol 56. Have done two cycles of IVF: First cycles I was on menopur (150) and gonal (initially 150 and bumped to 300) for about 11 days with… — Serena B.

Dr. Geoffrey Sher answered

In my opinion, you are young enough and have a normal ovarian reserve, such that egg quality should not likely be an inherent problem. In such cases, it is very often the protocol used for ovarian stimulation that plays a role here. It needs to be individualized to…
Egg Health & Ovarian Reserve Sep 17, 2024

IVF for Diminished Ovarian Reserve

I'm interested in speaking with only the best doctors as it relates my fertility. I look forward to speaking with you soon. I turned 49 recently. My odds of pregnancy with my own eggs are a long shot. I tell… — Teresa G.

Dr. Geoffrey Sher answered

At 49y, your only rql option is IVF with Egg donation....I am afraid, Geoff Sher IVF WITH EGG DONATION: A REVIEW Introduction: Egg donation is when a woman donates her eggs for assisted reproduction or research purposes. In assisted reproduction, it usually involves using IVF technology, where the…
Egg Health & Ovarian Reserve Sep 12, 2024

Low AMH, high AFC

I’ve been doing fertility treatments for five years. I have two kids. One with an IUI at age 35, one with IVF at 37. I’m now 40 and keep having trouble. My AMH is now .1, but my afc is… — Sara Q.

Dr. Geoffrey Sher answered

There is a high likelihood that aside from the age factor impacting egg quality, your severely diminished ovarian reserve sets you up fro what is known as "premature Luteinization". This is particularly more likely if the protocol used for ovarian stimulation is not optimally fashioned. ADDRESSING ADVANCING AGE…
Egg Health & Ovarian Reserve Aug 26, 2024

Same Agonist/Antagonist Conversion Protocols with Very Different AFC 6 Months Apart

Dr. Sher, I convinced my IVF doctor to let me use your agonist/antagonist conversion protocol with Zomacton (using Ganirelix to replace Lupron and keep using it until trigger date). My March cycle resulted in 4 eggs retrieved, 3 fertilized, unfortunately… — Meredith S.

Dr. Geoffrey Sher answered

There can be a very rapid decline in AFC at your age . This is because of inevitable decline in ovarian reserve and in egg quality. If you wish, you coulkd call my assistant Patti Converse at 702-533-2691 and set up an online consultation with me to discuss…
Egg Health & Ovarian Reserve Aug 26, 2024

Protocol for second round after low maturity in the first

Hi Dr Sher, We recently embarked on IVF after 1x TFMR at 24 weeks for genetic disorder (22q syndrome) of which neither me or my partner are carriers followed by 3x chemical miscarriage around 4.5/5 weeks. Our first cycle was… — Victoria L.

Dr. Geoffrey Sher answered

We should talk. There is no doubt in my my mind that the protocol used for ovarian stimulation has to be individualized to optimize egg/embryo "competency. I invite you to call 702-533-2691 and ask my assistant, Patti Converse, to set up an online consultation with me to discuss.…
Egg Health & Ovarian Reserve Aug 16, 2024

CoQ10

I am 43 years old with AMH of 3. My egg retrieval was yesterday. My HCG trigger did not absorb after 7 days of Stims and no priming starting on day 5 of my period. I was given 150 meno… — Kristin H.

Dr. Geoffrey Sher answered

The COQ10 likely had nothing to do with your follicle development. However, the protocol used for ovarian stimulation and/or its implementation, probably underlies your issue.We should talk: Please call my assistant, Patti Converse (702-533-2691 and set up an online consultation with me. EGG/ EMBRYO QUALITY IN IVF &…
Egg Health & Ovarian Reserve Aug 12, 2024

Transfer at age 45

Hello, Im am 45 . We have male factor infertility and in 2012 we got pregnant on our first try with a non medicated IUI using donor sperm. I had a healthy baby boy via C section. He is 11.5… — Emily B.

Dr. Geoffrey Sher answered

You clearly have diminished ovarian reserve. This in conjunction with your age (45y) makes the chance of successful pregnancy using your own eggs, very improbable. You actually need IVF with egg donation. Also, IUI has less than a 1:80 chance of success for you. If in spite of…
Egg Health & Ovarian Reserve Aug 12, 2024

Protocol

Hi, I am 44 with an Amh between 2.3 and 3 ng/ml, we had failed Icsis but always blastocysts. Would you also recommend the protocol you normally describe here or at the egg whisperer podcast in my case? Last year… — M M.

Dr. Geoffrey Sher answered

Your normal AMH at 44y comes as a surprise but that is decidedly in your favor. However, independently, age impacts egg "competency" and it is the egg (rather than the sperm that is most important in propagating normal "competent" embryos. Age should never be a barrier to hope…
Egg Health & Ovarian Reserve Aug 5, 2024

Trying to get pregnant

How can I get pregnant with 470 DHEA-S levels and irregular periods? I am 28 years old and we are trying to concieve since november 2023 — Rotila S.

Dr. Geoffrey Sher answered

An elevated DHEAS points to either over-ingestion of DHEA supplements or a possible adrenal factor. This needs to be looked into before proceeding any further. Might I suggest that you contact my assistant, Patti C9onverse at 702-281-7437 mand set up an online consultation with me. Geoff Sher,
Egg Health & Ovarian Reserve Jul 22, 2024

Ivf low responder

Dear Dr. Sher, I am in my late 30s and have an amh of 0,3. My period is very regular with regular ovulation (day 11 to 13) and I do not have any problems in the luteal phase like spotting.… — Sandra W.

Dr. Geoffrey Sher answered

I think I can help here! Please see my repose to your 2nd post...Same recommendation applies...We should talk. Geoff Sher
Egg Health & Ovarian Reserve Jul 22, 2024

Ivf low responder

Aldingen some additional information I forgot in my initial question: - no problems with uterine thickness and according to my doctor no signs of any scarves as due to thickness of approx 9-10 mm few days before ovulation - during… — Sandra W.

Dr. Geoffrey Sher answered

In my opinion, we should talk. I cannot provide authoritative advice on this information alone. I suggest you call my assistant, Patti Converse (702-533-2691) and set up an online consultation with me to discuss in detail. Geoff Sher ADDRESSING DIMINISHING OVARIAN RESERVE (DOR) IN IVF Understanding the impact…
Egg Health & Ovarian Reserve Jul 9, 2024

Repeat implantation failure

Hi Dr. Sher, I come from Denmark and here we can't screen our embryos - so we transfer untested. I have had all initial testing done in August last year before starting my egg retrievals and all my tests were… — Julie R.

Dr. Geoffrey Sher answered

Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

159 answers

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