Same Agonist/Antagonist Conversion Protocols with Very Different AFC 6 Months Apart

The question

Dr. Sher,
I convinced my IVF doctor to let me use your agonist/antagonist conversion protocol with Zomacton (using Ganirelix to replace Lupron and keep using it until trigger date). My March cycle resulted in 4 eggs retrieved, 3 fertilized, unfortunately none to blast. However, when I used the same protocol again earlier this month (August-2024), there is only 1 GV graded egg retrieved. It did mature overnight but fail to fertilized. I did a PRP session in May to hope to boost my ovary reserve. From your experience, is the difference of AFC and egg retrieval outcome more likely to be attributed to potentially spoiled medication (Gonal-f pens were gifted by other patients w an almost-expiring date) or my overall slow reaction to BCP? I've noticed that in both cycles, it took about 8 days from stopping BCP to have menses onset. If I don't use BCP and Lupron to start the protocol, would the conversion protocol still works for DOR patient like me?

My info:
46 yr old, AMH 0.34, FSH 2.6, LH 2.2 (all day 3 values)
highest stim dose: 300 IU gonal-f, 150 IU manepour daily

Thank you so much!

Asked by Meredith S. ·

Answer from Dr. Geoffrey Sher

There can be a very rapid decline in AFC at your age . This is because of inevitable decline in ovarian reserve and in egg quality. If you wish, you coulkd call my assistant Patti Converse at 702-533-2691 and set up an online consultation with me to discuss

Geoff Sher

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PLEASE SHARE THIS WITH OTHERS AND HELP SPREAD THE WORD!!

 

Herewith are  online links to 2  E-books recently  co-authored with  my partner at SFS-NY  (Drew Tortoriello MD)....... for your reading pleasure:

  1. From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS) ; http://sherfertilitysolutions.com/sher-fertility-solutions-ebook.pdf

 

  1. Recurrent Pregnancy Loss and Unexplained IVF Failure: The Immunologic Link ;https://drive.google.com/file/d/1iYKz-EkAjMqwMa1ZcufIloRdxnAfDH8L/view

 

I invite you to visit my very recently launched “Podcast”,  “HAVE A BABY” on RUMBLE;   https://rumble.com/c/c-3304480

If you are interested in having an online consultation with me, please contact my assistant, Patti Converse at 702-533-2691 or email her at concierge@sherivf.com\

General information only, not medical advice for your own situation. For that, book a consultation.

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