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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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Embryos & Genetic Testing Feb 24, 2023

Recurrent Miscarriage

After four losses (ages 23, 32, and 33) I was diagnosed with one copy of PAI-1 and one copy of MTHFR. I also have very high thyroid antibodies. Could all of this be causing the losses? We are moving on… — Mary P.

Dr. Geoffrey Sher answered

I doubt that the heterozygous PAI-1 and one copy of MTHFR can explain the losses. the thyroid antibodies is however another matter ...see below. Geoff Sher Between 2% and 5% of women of the childbearing age have reduced thyroid hormone activity (hypothyroidism). Women with hypothyroidism often manifest with…
Embryos & Genetic Testing Feb 23, 2023

Success after successful transfer

Hi! We just had our baby girl (4BB). Are the odds better doing a transfer for a second child since the first one worked? We had MFI and are 28! We transferred two embryos the first time (4AA & 4BB)… — Megan W.

Dr. Geoffrey Sher answered

I think your chance of success is good. I personally am willing to transfer up to 2 embryos at a time unless there is a specific obstetrics contraindication against twins. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my…
Embryos & Genetic Testing Feb 21, 2023

Frozen embryo

We are planning to transfer our previous frozen embryo, and I did currently semen analysis and found uroplasma, do my wife need an antibiotic before transferring the frozen embryo, and if yes what is the antibiotic and what is the… — Yousef S.

Dr. Geoffrey Sher answered

Ureaplasma urealyticum is a bacterium that belongs to the mycoplasma family. It can be detected in the reproductive tract of as many as 40% of individuals (male and female). Ureaplasma probably does not prevent normal conception in the majority of cases, because by and large, the uterine cavity…
Embryos & Genetic Testing Feb 16, 2023

Failed implantation

Hello, my husband and I have had a total of 6 good/top quality day 5 embryos implanted over the course of 2 years (2021- present). I have endometriosis, which I had surgery for in 2021. Following this surgery we had… — Ashley C.

Dr. Geoffrey Sher answered

Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or immunologic factors. IVF success rates…
Embryos & Genetic Testing Feb 14, 2023

Failed cycles

Hi, I learned of your clinic today on the egg whisperer and several questions arose from that video. I’ve had one retrieval with six day 5 embryos. My first fresh transfer failed with no implantation and my second was a… — Mary E.

Dr. Geoffrey Sher answered

There is a possibility that the hydrosalpinges could be playing a role here. However, it is important to also consider the possibility of an anatomical and/or immunologic implantation dysfunction. Please read below and then, if you are interested, contact my assistant Patti Converse (702-533-2691) and set up an…
Embryos & Genetic Testing Feb 9, 2023

Request for book download

Hi Dr. Sher, I am an IVF patient of Dr. Randall Loy (RE) at the Center for Reproductive Medicine in Winter Park, Florida. I am also a patient of Dr. Jubiz Giovanni (RI) in Kissimmee, Florida. After two losses and… — Michelle R.

Dr. Geoffrey Sher answered

ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS) “ http://sherfertilitysolutions.com/sher-fertility-solutions-ebook.pdf “Recurrent Pregnancy Loss and Unexplained IVF Failure:…
Embryos & Genetic Testing Feb 9, 2023

Sonohysterogram during a FET

Hi Dr Sher, do you believe its okay to get a Sonohysterogram done during cycle day 6 - 11 of a medicated Frozen Embryo Transfer cycle? Can the medication (Estrogen and Progesterone) interfere with the SHG results or vice-versa? — Jennifer L.

Dr. Geoffrey Sher answered

Respectfully! I personally would not perform a SNH during a cycle of FET! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A…
Embryos & Genetic Testing Jan 28, 2023

Follow up to last question- 3 miscarriages

Hi, to add on to my last question. 3 miscarriages (1 at 6 weeks before heartbeat, 2 measuring 9 weeks after strong heartbeat detected with one being a PGT normal embryo). The only thing that we have found is one… — Kaitlin M.

Dr. Geoffrey Sher answered

A heterozygous MTHFR mutation will in my opinion, not cause early pregnancy loss. When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30%…
Embryos & Genetic Testing Jan 28, 2023

Elevated Anticardiolipin

Hi Dr. Scher! I've been listening to a few of your interviews with Dr. Aimee on her podcast and am very grateful for the helpful information you provide. I am 34 years old and have an almost 3-year old daughter… — Susanne S.

Dr. Geoffrey Sher answered

It is highly unlikely the the elevated aCL alone would lead to secondary recurrent pregnancy loss (RPL). I would venture an educated guess that there is a non-immunologic cause for implantation dysfunction (perhaps the integrity of the uterine cavity or a thin uterine lining). More likely however is…
Embryos & Genetic Testing Jan 28, 2023

3 miscarriages

Hi- I have had 3 miscarriages in the last 15 months. First happened at 6 weeks. No heartbeat/questionable fetal pole. Second and third happened after strong heartbeat- measuring 9 weeks. Third was through IVF and was a PGT normal embryo.… — Kaitlin M.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost within 10 weeks of conception (in the…
Embryos & Genetic Testing Jan 22, 2023

PGT embryos no implantation

Hi, Why would I get pregnant naturally twice (ended in 6 week miscarriages) within 6 months, but have had 2 good quality pgt embryos fail to implant? Why would it implant naturally and not with IVF? Thanks — Laura P.

Dr. Geoffrey Sher answered

This sounds like implantation dysfunction. Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or…
Embryos & Genetic Testing Jan 22, 2023

Repeated Chemical Pregnancies

I have done 3 FETs with PGT-A tested euploid embryos. Results were 1 pregnancy that ended at 14.5 weeks due to genetic abnormalities, followed by 2 chemical pregnancies in the last 8 months. Since my 14.5 week loss, I have… — Alysa W.

Dr. Geoffrey Sher answered

RECURRENT PREGNANCY LOSS (RPL) Geoffrey Sher MD. When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost…
Embryos & Genetic Testing Jan 18, 2023

Day 7 embryo

Hello doc. Our last euploid embryo is day 7 cc grade. We’re not very optimistic to be honest. What are the success rates of day 7 embryos? I have read some mixed data. I was 29 at time of egg… — A. A.

Dr. Geoffrey Sher answered

Respectfully, the success rate with day-7 blastocysts is very poor...even if it is assessed as being euploid Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro…
Embryos & Genetic Testing Jan 17, 2023

Implantation testing

Hi Dr Sher, I hope all is well. I just received my results for implantation tests and I was told that my vaginal microbiome was "low" - good bacteria content was low. The advice to do not do anything, just… — Cassidy O.

Dr. Geoffrey Sher answered

I do not believe in Microbiome testing. Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium)…
Embryos & Genetic Testing Jan 7, 2023

5th embryo transfer failed

What can you advise for me to do after my 5th embryo is unsuccessful? Thank you and appreciated your response. — Ruby H.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

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