Premature Luteinization (“the premature LH surge): Why it Happens and how it can be Prevented

Premature luteinization (“premature LH surge”) occurs when prior to
the planned initiation of the hCG trigger, a progressive rise in LH,
irreversibly compromises follicle and egg development and maturation.
It is not a sporadic isolated event. It comes as a culmination of a
series ovarian events, occurring mostly in susceptible women (i.e.
usually older women and those with diminished ovarian reserve. It is
more likely to occur when the protocol used for o…

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Uterine Fibroids and Fertility

Fibroids or leiomyomas are non-malignant muscle tumors that grow in
the uterine wall. They can be found in about one out of every five
(1:5) women >30Y of age. Fibroids are far more prevalent in African
Americans and women and less frequent in other ethnic groups (i.e.
Caucasians and Asians). Fibroids, enlarge and/or distort uterine
configuration. They can produce symptoms such as heavy, painful and
prolonged menstrua…

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Induction of Ovulation With Clomiphene Citrate: Mode of Action, Indications, Benefits, Limitations and Contraindications for its use

Clomiphene (Clomid, Serophene) is by far the most widely prescribed
agent for the induction of human ovulation for women who do not
ovulate, those with dysfunctional ovulation and women with
”unexplained” infertility. When used in young women (who have
adequate ovarian reserve) with these problems the viable pregnancy
rate is reported as being between 6% and 10% per cycle of treatment.
Aside from conventional ovulation induction, clomiphene has been us…

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How Many Embryos Should be Transferred: A Critical Decision in IVF

The decision on how many embryos to transfer confronts most IVF
physicians and their IVF patients. It is driven by a goal that both
share in common, namely that of optimizing the chance of IVF treatment
resulting in pregnancy. Clearly, the more embryos transferred, the
greater the likelihood of success. However, there is overwhelming
evidence to show that the more embryos transferred to the mother’s
uterus, the greater the risk of a multiple pregnancy re…

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Frozen Embryo Transfer (FET): A Rational Approach to Hormonal Preparation and How new Methodology is Impacting IVF

Until about 15 years ago, we believed that the best and safest way to
cryopreserve embryos was by using a slow freezing method. What we
subsequently learned was that the slow freezing process caused the
formation of intracellular ice and that this, by damaging embryos and
compromised their post-thaw survival as well as IVF outcome,
significantly. The introduction of ultra-rapid embryo freezing
(vitrification) has changed all that. With vitrification, embry…

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IVF- A Moral And Ethical Dilemma: Disposing of Left-Over Human Embryos

Human life can be defined as any living entity that contains viable
human DNA. There are two issues. The first is when does life begin and
the second is when is it endowed with “personhood.Pro-choicers
believe that the transition from human “life” to human
“personhood” occurs throughout pregnancy and accordingly, that the
status of an embryo lies in its potential to pro…

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Adenomyosis Related Infertility: A Therapeutic Challenge

Adenomyosis is a condition where endometrial glands develop outside
the uterine lining (endometrium)
[/blog/viagra-treatment-thicken-uterine-lining/], within the muscular
wall of the uterus (myometrium). A definitive clinical diagnosis of
adenomyosis is difficult to make. The condition should be suspected
when a premenopausal woman (usually>25 years of age) presents with
pelvic pain, heavy painful…

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IVF: How do you decide how many embryos to transfer?

The majority of IVF patients intuitively recognize that the more
embryos transferred the greater will be the chance of their getting
pregnant. However in their preoccupation with conceiving as quickly as
possible they often tend to ignore the serious and sometimes
life-endangering risks to both mothers and children associated with of
multiple pregnancies (particularly with triplet pregnancies of
greater) that are far more likely to occur when multiple embr…

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