Dr. Geoffrey Sher

Endometriosis and Immunologic Implantation Dysfunction (IID) and IVF

More than half of women who have endometriosis harbor antiphospholipid
antibodies (APA) that can compromise development of the embryo’s root
system (trophoblast). In addition and far more serious, is the fact
that in about one third of cases endometriosis
[/blog/endometriosis-and-ivf/], regardless of its severity is
associated with NKa and cytotoxic uterine lymphocytes (CTL) which can
seriously jeopardize implantat…

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IVF: A Personalized Step-by Step Approach

The ability to grow a healthy plant requires that a “good” seed be
planted in a “fertile soil” and then be properly nurtured until
it can thrive on its own….independent of intervention.
Similarly, successful IVF requires the same relationship, only here,
a “good seed” is a “competent, chromosomally normal (euploid)
embryo and “fertile soil” is a “receptive” uterine
lining (endometrium). You cannot expect success through planting a
“bad seed” in a “fert…

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IVF: How many tries should be considered before stopping?

Because of the emotional, physical, and financial toll exacted by IVF
[/blog/treating-state-country-patients-sher-ivf-las-vegas/], it is
preferable that no one undertake a one shot attempt. If a couple can
only afford one treatment cycle, IVF
[/blog/treating-state-country-patients-sher-ivf-las-vegas/] is
probably not the right course of action.  After all, with
conventional…

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“Unexplained” Infertility : Often a matter of the Diagnosis Being Overlooked!

For about 10% of all infertile couples, the cause of the infertility
cannot be readily determined using conventional diagnostic methods.
Such cases are often referred to as “unexplained infertility.” The
truth however is that in most such cases, the diagnosis of
“unexplained infertility is in fact presumptive because a more
in-depth evaluation would have revealed a cause. This having been
said, people diagnosed with so called “unexplained infertility”
fall into two broad groups: a)…

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The Role of IVF in Cases of Tubal Damage

Tubal damage is one of the commonest causes of infertility. It is most
often due to pelvic inflammatory disease (PID)
[/blog/pelvic-inflammatory-disease-pid-tubal-damage-hydrosalpinx-preparing-ivf/]
caused by sexually transmitted bacterial infection with chlamydia
trachomatis and Neisseria gonorrhea. Acute PID caused by such usually
are associated with severe clinical manifestations such as rapid …

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Ovarian Stimulation in Women Who have Diminished Ovarian Reserve (DOR): Introducing the Agonist/Antagonist Conversion protocol

The use of GnRH antagonists, as currently prescribed in ovarian
stimulation cycles
[/blog/optimizing-response-ovarian-stimulation-women-compromised-ovarian-reserve-personal-approach/],
i.e. the administration of 250mcg daily from the 6or 7th day of
stimulation with gonadotropins, is in my opinion problematic when used
in women who have

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Intralipid (IL) Administration in IVF Explained

Intralipid (IL)
[/blog/intralipid-ivig-therapy-treatment-immunologic-implantation-dysfunction/]is
a solution of small lipid droplets suspended in water. When
administered intravenously, IL provides essential fatty acids,
linoleic acid (LA), an omega-6 fatty acid, alpha-linolenic acid (ALA),
an omega-3 fatty acid. It is made up of 20% soybean oil/fatty acids
(comprising linoleic acid, oleic acid, p…

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Prevention, Recognition, and Treatment of Hydatidiform Molar Pregnancies

A hydatidiform molar pregnancy [/blog/molar-pregnancy-treated/]
happens when tissue that normally forms the placenta instead becomes a
growth, that triggers symptoms of pregnancy. A hydatidiform mole is a
benign tumor of the root system (trophoblast) of the embryo which
under normal conditions develops into the placenta which connects the
baby to the mother. About 1 out of 2,000 women with early pregnancy
symptoms will have a molar pregnancy. I…

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