Dr. Geoffrey Sher

Case Report: Intractable Damage to the Uterine Lining (Asherman Syndrome ) causing Failed Implantation

Marissa (39y) and her husband, Pete (43y) presented with a history of
having had 2 healthy children together. Marissa was a normally
menstruating/ovulating lady with a fertile husband. The birth of her
2nd child was complicated by partial delivery of the placenta and
  was accompanied by a post-partum hemorrhage (bleeding). A manual
removal of the retained piece of placenta was undertaken following
which her uterus was deemed to be empty. After the birth of her baby,
Marissa…

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Selecting the Ideal Protocol for Controlled Ovarian Stimulation!

 “IVF IS NEITHER A PURE ART OR A PURE SCIENCE. RATHER IT IS A BLEND
OF BOTH!”“Virtually nothing that we do clinically in IVF can be
fully supported or validated by “gold standard statistical analysis.
This is because in the ART setting, when it comes to establishing
comparative evidence of clinical efficacy, randomized controlled
statistical assessments cannot be applied.  Such determinations of
outcome would require stabilizing all…

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Case Report: Endometrios Causing IVF Failures due to Embryo Implantation Dysfunction (IID)

After 4 years of trying to conceive without any success, Rosa (35y)
and her husband Jim (42y), achieved a spontaneous pregnancy in 2014.
Sadly, the pregnancy miscarried at 5 weeks. Jim had perfectly normal
sperm parameters. Rosa underwent a hysterosalpingogram as well as a
saline ultrasound hysterosonogram), in 2016. Both were normal. Then in
2016, Rosa underwent a laparoscopy where she was diagnosed as having
moderately severe endometriosis. All visible endometriotic lesions
were ablate…

Case Report: Endometrios Causing IVF Failures due to Embryo Implantation Dysfunction (IID) Read More »

Case Report: Woman with Diminished Ovarian Reserve (DOR) and Age-related Secondary Infertility whose Husband has Autoimmune Infertility Following Vasectomy Reversal

Juanita, a 42y old who, between 2003 and 2007, had delivered 3
children in a prior relationship. Carlos, her new partner of 3 years,
had 3 children through spontaneous conception, in a prior
relationship. He had undergone vasectomy in 2004 and had a surgical
reversal performed in 2015. Although he was never tested for antisperm
antibodies, Carlos’s 70%-80% sperm agglutination suggests that he
had such. Clearly the only treatment for the latter is IVF/ICSI.
Juanita was found to have an …

Case Report: Woman with Diminished Ovarian Reserve (DOR) and Age-related Secondary Infertility whose Husband has Autoimmune Infertility Following Vasectomy Reversal Read More »

Case Report: Recurrent IVF Failure due to Uterine Adenomyosis and Intrauterine Fibroid Polyps, Requiring Gestational Surrogacy

Linda (43y) and her husband Graham (49y) had been trying to conceive
for 6 years. She had been pregnant once before in 1993. This
pregnancy, which was initiated in a previous relationship was aborted,
without subsequent complications. Linda had been having regular
ovulatory menstrual cycles. Her general health was excellent but her
family history was positive for amyotrophic lateral sclerosis (AML).
In 2016 Linda underwent a hysteroscopic myomectomy for the removal of
a small fibroid pol…

Case Report: Recurrent IVF Failure due to Uterine Adenomyosis and Intrauterine Fibroid Polyps, Requiring Gestational Surrogacy Read More »

Endometrial Receptivity Array (ERA): Is There an actual There, There?

The blastocyst and the endometrium are in a constant state of
cross-talk. In order for successful implantation to take place,
the blastocyst must be at the appropriate stage of development, and
needs to signal a well synchronized endometrium  to ‘accept it”.
This dialogue between embryo and endometrium involves growth factors,
cytokines, immunologic accommodations, cell adhesion molecules, and
transcription factors. These are all mostly genetically driven but are
also heavily infl…

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Case Report: “Unexplained” Recurrent IVF failure: Was the Underlying Cause Overlooked?

Mary, a 37y female had never conceived in spite of >6 years of trying.
. She had undergone multiple (failed) cycles of IVF-with
intracytoplasmic sperm injection (ICSI). Her husband, Brian, was
originally diagnosed with oligospermia with a sperm count of 18-20
million/mL and 40% motility. Repeat semen analyses at different labs
showed similar findings. However, several years later when the couple
decided to try much to their surprise, a repeat semen analysis showed
absence of sperm in the…

Case Report: “Unexplained” Recurrent IVF failure: Was the Underlying Cause Overlooked? Read More »

Case Report: Patient with Repeated IVF Failures, Diminished Ovarian Reserve (DOR) and Autoimmune Hypothyroidism (Hashimoto’s Disease)

Beryl, 39y and her husband Jack is 36y presented with a history of 5
years of infertility. They had failed 2 attempts at IVF (both in
2918). Beryl had normal regular, ovulatory menstrual cycles. She had
hypothyroidism caused by an autoimmune process, secondary to the
presence of antithyroid antibodies (Hashimoto’s disease). She had a
laparoscopy done about 18 months prior and was found to have a normal
uterus and patent Fallopian tubes. A concomitantly performed
hysteroscopy (to examin…

Case Report: Patient with Repeated IVF Failures, Diminished Ovarian Reserve (DOR) and Autoimmune Hypothyroidism (Hashimoto’s Disease) Read More »

Case Support: Diminished Ovarian Reserve (DOR) + Male Infertility

CASE REPORT #1: ADVANCING AGE, DIMINISHED OVARIAN RESERVE (DOR) + MALE
INFERTILITY Geoffrey Sher MD CASE HISTORY: Mary D. (42y) and her
husband, Chris (43y) recently had a SKYPE consultation with me. The
couple had been trying to have a baby for 1.5 years. Maria had been
pregnant when she was 19 years of age and had an abortion without any
subsequent complications. Aside from having had her gallbladder
removed laparoscopically in 2015, she other…

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Launching of Sher-Fertility Solutions and Future Case Supports

With the launching of Sher-Fertility Solutions (SFS), I will as of
April 1st, take on a new and expanded consultation role. Rather than
having hands-on involvement with IVF procedures I will, through SFS,
instead provide fertility consultations (via SKYPE) to the
ever-growing number of patients (emanating from >40 countries) who
have complex Reproductive Dysfunction (RD) and who seek access to my
input , advice and guidance. Subject to agreement on the part of their
personal RE’s, I hope…

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