I (33 years old) have a small piece of “benign” genetic material (#15) mosaically which may be contributing to recurrent natural pregnancy loss (4 losses, 2 were between 10-16 weeks with confirmed T18 and T21). Genetic Counselors could not confirm there is any relationship between my genetic material causing my fertility issues or the likelihood of genetically unbalanced embryos. After discovering this we decided to go the IVF route with PGT-A tested embryos/FET, as we thought getting pregnant wouldn’t an issue as we were able to naturally, but genetically healthy embryos was an existing proven issue. Once doing a retrieval we started with 5 frozen PGT-A tested euploid embryos (Day 5s). Since then we’ve had 3 unsuccessful transfers with no success. I went for ERA, EMMA and ALICE testing to rule out other potential undiagnosed complications. The results did not signify any issues with the existing approach. Each protocol has been a natural modified protocol. The first was mini stims with follistim, and menopur and no trigger shot. The next 2 included tamoxifen to start, follistim, and pregnyl as the trigger shot. We are now at a crossroads of what to do, what to change and if any other treatment could be possible. It seems we keep trying the same approach and failing, and are becoming more and more nervous now that we only have 2 embryos remaining, as the most often response we’ve heard throughout our entire fertility journey has been “it’s just bad luck”. Is there something we’re missing?