Hi,
I’ve had two egg collections resulting in 5 embryos (3 of which didn’t survive thawing) and 3 on the second round.
In my first fresh embryo transfer I passed a couple of large blood clots the day after transfer, with no heavy bleeding and a negative result. I was told this could likely be low progesterone levels so in the following frozen transfer had two Crinone gels and a lubion injection daily. I had no symptoms or bleeding and a negative result.
In the second fresh embryo transfer at a different clinic I took two cyclogest pessaries and a lubion injection daily. I had light pink/brown spotting and cramps after a few days which I took to be implantation (I had been pregnant naturally before but had a miscarriage at 5 weeks and this felt similar) this lasted a couple of days then tailed off. After another couple of days I had heavy bleeding with large clots.
I was told by the clinic they didn’t know why this would happen as my progesterone levels were 396, and that in the next frozen cycle the gradual increase of eostrogen should make it less likely to happen again. I have just had this transfer on a modified natural cycle, with no medicated eostrogen and two cyclogest pessaries daily and a lubion injection every 3 days. Again, I had light pink spotting and cramps a few days later, 4/5 post transfer, this tailed off and a couple of days later I had bright red spotting. I continued taking the progesterone as instructed by the clinic but this spotting has continued until today, 11 days post transfer. I’ve taken an early pregnancy test every day for the last few days with negative results. I forgot to take my cyclogest pessary last night, took the next one on time this morning, but am now having severe cramps and the bleeding is now heavier.
I want to understand why this keeps happening when our embryos are top grade and my progesterone levels are so high. I’ve been told that even if the IVF is unsuccessful I shouldn’t be having this bleeding during treatment.
I’ve been told I have adenomyosis and a fibroid but this is localised and away from the womb cavity so shouldn’t be affecting implantation. I’ve read that embryo development can fail due to chromosomal issues. My husband had leukemia as a young child and I’ve read it could have long term negative impacts on sperm, but we haven’t had any detailed tests on his sperm other than the standard tests in the UK. Could this be causing the bleeding? What can we do in our next cycle to prevent this happening again?