The question
Hello doctor Sher,
Thanks for taking the time to answer our questions!!
Is it true that vaginal estrogen route result in higher serum estradiol unlike transdermal and intramuscular? Does the estradiol level a day to pio matter ? Can it be too high? What is your cut off?
Thank you doctor!
Answer from Dr. Geoffrey Sher
My preference is subcutaneous estradiol twice weekly injections.. My second preference is trans dermal. Vaginal estradiol is not evenly absorbed and oral estradiol is in my opinion the poorest choice because absorption through the GIT passes via the liver to the systemic circulation and this can alter the estradiol. Ideal blood levels of E2 is 500-1000pg/ml.
Good luck!
General information only, not medical advice for your own situation. For that, book a consultation.