I have had several miscarriages the last 2 after IVF but I've never been tested for autoimmune implantation dysfunction even though I have Lupus, Celiac disease, and Rheumatoid arthritis. I have 2 frozen embryos and am 47. My current husband and I have been exploring...
Currently there are fewer than a dozen immunology reference
laboratories in the U.S that are capable of analyzing the required
elements with a sufficient degree of  sensitivity and specificity as
to be reliable in my opinion. These elements include measuring blood
levels of the eighteen to twenty IgA, IgG and IgM-related APA’s that
are directed against six or seven specific phospholipids, as well as
assessing Natural Killer (NK) cell activity (cytotoxicity) as measured
by their killi…
In the United States, effective treatment of NK/CTL activation
associated with either alloimmune or autoimmune implantation
dysfunction requires the administration of primarily Intralipid (IL)or
Intravenous gamma globulin (IVIg) plus corticosteroid. Such treatment
is much more likely to be successful in the case of` autoimmune
implantation dysfunction where the NK/CTL activation is present in
advance of the uterus being exposed to the embryo. It is not nearly as
effective for the treatme…
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In 15-20% of women who have infertility or RPL, the cause will be
immunologic implantation dysfunction (IID). Accordingly, all women who
have predisposing factors such as endometriosis, unexplained
infertility/repeated failed IVF, RPL, or have a personal/family
history of primary autoimmune conditions, should be evaluated and
treated appropriately. By doing so, we as phys…
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Between 2% and 5% of women of the childbearing age have reduced
thyroid hormone activity (hypothyroidism). Women with hypothyroidism
often manifest with reproductive failure i.e. infertility, unexplained
(often repeated) IVF failure, or recurrent pregnancy loss (RPL). The
condition is 5-10 times more common in women than in men. In most
cases hypothyroidism is caused by damage to the thyroid gland
resulting from of thyroid autoimmunity (Hashimoto’s disease) caused
by damage do…
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Central to making a diagnosis of an immunologic implantation
dysfunction (IID) is a need for the appropriate interpretation of
Natural Killer Cell Activity (NKa). In this regard, one of the
commonest and most serious errors, is interpret the blood
concentration of natural killer cells as being relevant. Rather it is
the activity (toxicity) of NK cells that matters as mentioned. This
activity can best be measured using the blood, K-562 target cell test
(the gold standard). and/ o…
In the United States, effective treatment of NK/CTL activation
associated with either alloimmune or autoimmune implantation
dysfunction requires the administration of primarily Intralipid (IL).
Such treatment is much more likely to be successful in the case of`
autoimmune implantation dysfunction where the NK/CTL activation is
present in advance of the uterus being exposed to the embryo. It is
not nearly as effective for the treatment of alloimmune implantatio…
In the United States, effective treatment of natural killer cell
/cytotoxic lymphocyte (NK/CTL)-activation associated with either
alloimmune or autoimmune implantation dysfunction requires the
administration of primarily Intralipid (IL) or Intravenous
gamma-globulin (IVIg). Such treatment is much more likely to be
successful in the case of` autoimmune implantation dysfunction where
the NK/CTL activation is present in advance of the uterus being
exposed to the embryo. It is not nearly a…
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