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Endometriosis and Immunologic Implantation Dysfunction (IID) and IVF

More than half of women who have endometriosis harbor antiphospholipid
antibodies (APA) that can compromise development of the embryo’s root
system (trophoblast). In addition and far more serious, is the fact
that in about one third of cases endometriosis
[/blog/endometriosis-and-ivf/], regardless of its severity is
associated with NKa and cytotoxic uterine lymphocytes (CTL) which can
seriously jeopardize implantat…

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Intralipid and IVIG Therapy in the Treatment of Immunologic Implantation Dysfunction

By Dr. Geoffrey Sher

There is an ever growing realization, recognition, and acceptance of
the fact that uterine immunologic dysfunction can lead to immunologic
implantation dysfunction (IID)
[/blog/diagnosing-and-treating-immunologic-implantation-dysfunction-iid/]
with “unexplained” infertility, IVF failure
[/blog/unexplained-ivf-failure/], and…

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Natural Killer Cell Activation (NKa) and Immunologic Implantation Dysfunction (IID) in IVF: The Controversy!

By Dr. Geoffrey Sher

“Innovators are rarely received with joy, and established
authorities launch into condemnation of newer truths; for at every
crossroad to the future are a thousand self-appointed guardians of the
past.”

Natural Killer Cell Activation (NKa) and Immunologic Implantation Dysfunction (IID) in IVF: The Controversy! Read More »

Immunologic Implantation Dysfunction: Importance of Meticulous Evaluation and Strategic Management: (Case Report)

By Dr. Geoffrey Sher

Greetings Dr. Sher! Just wanted to first thank you for all that you do
for women and infertility and I’m truly amazed and grateful at how
you are so willingly to share your knowledge and help women achieve
pregnancy. As for me, my background – Diagnosed with endometriosis
at age 19 when I lost one ovary/tube. Struggled with recurrent endo
and had multiple surgeries for endometriomas. Stayed on continuous BCP
for more than 15 years. At about 37 tried a few rounds of in vitro,
low slow…

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Advantages of Combining Preimplantation Genetic Sampling (PGS) with Tests for Immunologic Implantation Dysfunction (IID)

By Dr. Geoffrey Sher

Whenever IVF fails to resolve reproductive failure, the explanation is
almost invariably either: a) embryo “incompetence” (usually
…although not always due to the embryo being karyotypically abnormal
or aneuploid) or b) implantation dysfunction (anatomical/
immunologic). So…should the transfer of up to two (2)
karyotypically

Advantages of Combining Preimplantation Genetic Sampling (PGS) with Tests for Immunologic Implantation Dysfunction (IID) Read More »

IVF Failure and Implantation Dysfunction: The Role of Endometrial Thickness, Uterine Pasthology and Immunologic Factors

By Dr. Geoffrey Sher

The considerable emotional, physical and financial burden associated
with infertility treatment in general and with IVF in specific, demand
that factors known to affect outcome be identified and regulated prior
to initiating treatment. Just as a successful garden needs a
”good” seed properly planted in fertile soil to produce healthy
plants, successful embryo implantation requires a good seed
(genetically “norma…

IVF Failure and Implantation Dysfunction: The Role of Endometrial Thickness, Uterine Pasthology and Immunologic Factors Read More »

Implantation Dysfunction

By Simplicity Web

Implantation Dysfunction Rather it is the activity (toxicity) of NK cells that matters as mentioned. This activity can best be measured using the blood, K-562 target cell test (the gold standard) and/or endometrial biopsy for cytokine activity. With the K-562 test, the most important consideration is the percentage of target cells “killed” in the “native

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The Impact of a Thin Uterine Lining on Embryo Implantation and the Benefits of Viagra Therapy

By Dr. Geoffrey Sher

Back in 1989, I conducted a study that examined how the thickness of a woman’s uterine lining, known as the endometrium, affected the successful implantation of embryos in IVF patients. The study revealed that when the uterine lining measured less than 8mm in thickness by the day of the “hCG trigger” in fresh IVF cycles,

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IVF Failure With “Normal” Embryos: Examining and Addressing Anatomical and Immunologic Causes

By Dr. Geoffrey Sher

Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success rates have been improving in the past

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Embryo Implantation Dysfunction

By Dr. Geoffrey Sher

Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or immunologic factors. IVF success rates have been improving over the last decade.

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