– Geoffrey Sher, MD
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Embryos & Genetic Testing
I recently got an embryo report back from coopergenomics and it's euploid, but my PGT-M result came back with maternal chromosome contamination. Do you think this can effect success rates? — Julie G.
Dr. Geoffrey Sher answered
You need to discuss this with your personal RE. Good luck! Geoff Sher
Embryos & Genetic Testing
Are two healthy blastocyst enough for a successful implantation? I need to talk to you doctor privately , I live in a very far country and I can't see you , is it possible to discuss my situation with you… — Monica L.
Dr. Geoffrey Sher answered
I transfer up to 2 blastocysts at a time...but no more. Please call my assistant Patti Converse at 702-533-2691 or email her at concierge@sherivf.com and set up an online consultation with me. Geoff Sher
Immunology & Implantation
I have implantation dysfunction. 6 transfers of 7 embryos have failed (our last being a PGS normal). I do have low LADs but never got HLA/DQ Alpha testing. We have moved on to surrogacy with my husbands sister. Transferred a… — Karly W.
Dr. Geoffrey Sher answered
Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or immunologic factors. IVF success rates…
Immunology & Implantation
Hello Dr, My question is, it possible to just keep trying naturally in the hope that there will at some stage not be a match and a pregnancy will proceed normally without any intervention? I have had 4 miscarriages so… — Emma P.
Dr. Geoffrey Sher answered
DQ alpha matching is in my opinion only a problem if it is associated with NK cell activation (see below). When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not…
Embryos & Genetic Testing
I have done an I VF and I am right now in the two week wait anxiety . I have tried 4 times previously and have a failure . The doctor this time did surgical scratching for the uterus ,… — Monica E.
Dr. Geoffrey Sher answered
I suggest you await the outcome and if you do not conceive, that you contact my assistant Patti Converse (702-533-2691) and set up a consultation online, with me. Good luck! Geoff Sher
Age & Fertility
Hola, soy Juan Francisco Martínez , tengo 39 años, recientemente he sido diagnosticado de de una mutación en el gen que codifica la proteína Desmina, con leve repercusión cardiomiopática en el momento actual aunque hay antecedentes de muerte súbita en… — Martinez J.
Dr. Geoffrey Sher answered
Please post your question in English!
Embryos & Genetic Testing
I'm 36 and doing IVF with PGT-A and PGT-M to avoid passing on a genetic condition I'm a carrier for. I don't have any identified fertility issues and have had a viable natural pregnancy before at age 34. I've had… — Charlotte D.
Dr. Geoffrey Sher answered
Frankly, you and I should have an in depth discussion to address these issues. I do not believe there is merit in transferring day 7 blastocysts whether or not they are euploid. The chance of pregnancy is dismal. There could be embryo issues relating to a possible deficiency…
Embryos & Genetic Testing
Hi Dr Sher. I am from New Zealand and almost 2 years on in my fertility journey. I’m 42 now and have 3 children of my own. My husband has 1. We are both fit and healthy. I’ve always had… — Barbara C.
Dr. Geoffrey Sher answered
Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
Embryos & Genetic Testing
Hello Dr. I have had 3 MCs ( chromosome issues) 3 rounds of er, in total 34 eggs, 23 fertilized, 5 blasts no euploid, 1 failed fresh 3-day transfer. I am 40 started all this when I was 38. My… — Desiree B.
Dr. Geoffrey Sher answered
There is really a great deal to talk about here. I strongly urge you to call my assistant Patti at 702-533-2691 and set up an online consultation with me. Given your history of 3 losses I think that aside from an egg/embryo quality issue you could, in addition,…
Male Infertility
Hello Dr. Sher, My husband's semen analysis came back as 250 million motile sperm but only 4% morphology. Is such low morphology an issue in your professional experience? Does this mean that its basically 10 million sperm that are ok… — Lisa M.
Dr. Geoffrey Sher answered
This quite acceptable. I do not see it as a significant issue at all.when it comes to IVF/ICSI, Geoff Sher
Immunology & Implantation
Hi, we have been facing recurring losses, dq alpha complete match, nk cells causing allergic reactions at the time of implantation. Is there anything you can suggest for us to be pregnant. I'm 40 and my husband 39, we don't… — Shama S.
Dr. Geoffrey Sher answered
When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost within 10 weeks of conception (in the…
Early Pregnancy & hCG
What test would you consider if someone had 4 miscarriages before 6 weeks I have done all the basic test Immune conditions Chromosome Ovarian reserve My husband sperm Protein Std Everything is normal No polyps I do have fibroids not… — Medjine E.
Dr. Geoffrey Sher answered
When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost within 10 weeks of conception (in the…
Hormones & Ovulation
Hello doctor Sher, Thanks for taking the time to answer our questions!! Is it true that vaginal estrogen route result in higher serum estradiol unlike transdermal and intramuscular? Does the estradiol level a day to pio matter ? Can it… — Indo I.
Dr. Geoffrey Sher answered
My preference is subcutaneous estradiol twice weekly injections.. My second preference is trans dermal. Vaginal estradiol is not evenly absorbed and oral estradiol is in my opinion the poorest choice because absorption through the GIT passes via the liver to the systemic circulation and this can alter the…
Male Infertility
Hi, My partner and I have had a friend that was successful at your clinic (Michelle and Steve Christie) and we are exploring a child together but do not have the funds to have it not be successful going back… — Kristen S.
Dr. Geoffrey Sher answered
Here is some information on : Previous vasectomy and IVF; Gender selection and Endometriosis and infertility. We should talk,. call Patti Converse (702-533-2691) and set up an online consultation with me. 1. GENDER SELECTION Couples have for centuries sought to influence the gender of their offspring. More than…
Uterine & Endometrial Health
Hi, I came across your page because I have been dealing with a 5 cm endometrioma and have been looking at different options. I found your article about ovarian sclerotherapy and was wondering if you know where this procedure can… — Sophia G.
Dr. Geoffrey Sher answered
I really do not know who offers this or where you could find out! You will have to inquire around. Geoff Sher
