Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

Search the answers our doctors have already given

Fill in the following information and we’ll get back to you.

Answers from our doctors

Search 1,019 questions patients have already asked, or narrow them by topic.

Latest answers

Page 56 of 68

Embryos & Genetic Testing Mar 7, 2023

Repeated implantation failed

After having had several failed implantations of healthy embryos, I did blood tests and obtained very high values of Factor X activity, clothing, and Factor XII activity clothing. What does it mean and how does it affect me? What's the… — Sofia G.

Dr. Geoffrey Sher answered

I really don't think this is likely to be a problem. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with…
Immunology & Implantation Mar 7, 2023

Autoimmune test results

Hi Dr Sher, I've been following your work for some time and I really hope you can help. I'm based in the UK and have just had my second unsuccessful IVF cycle in Prague (first IVF was with the NHS… — Angela E.

Dr. Geoffrey Sher answered

Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. In the pursuit of optimizing outcome with IVF, the clinician has a profound responsibility to meticulously assess and address this important issue if IVF success is to be optimized. This is especially relevant in cases…
Uterine & Endometrial Health Mar 7, 2023

Progesterone dose and levels concern

My doctor tested my progesterone (P) levels 1 day after 5 day transfer and said it was 103 (Canadian units) but that it should be 50-100. He dropped my dose from 50 mg PIO to 12.5 mg without rechecking it… — Lauren C.

Dr. Geoffrey Sher answered

The decision is between you and your treating RE. I might have done differently, but I doubt it will make a difference. Good luck! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD).......…
Immunology & Implantation Mar 6, 2023

High Foxp3 T-Cells

Hi Dr Sher, My Proliferative Phase Endometrium Immune Cell Studies on CD9 came back with Natural Killer Cells present at 5.1% and Foxp3 cells at 26/mm2. My fertility specialist has included in my next treatment plan for a FET for… — Katrina P.

Dr. Geoffrey Sher answered

I am sending you a copy of my book on immunology. You will see that I use a different approach for fixing on treatment. Geoff Sher Currently, with few exceptions, practitioners of assisted reproduction tend to attribute “unexplained and/or repeated” IVF failure(s), almost exclusively to poor embryo quality,…
Embryos & Genetic Testing Mar 4, 2023

Aneuploid Embryos

Hello Dr Sher! I was wondering if any of these "aneuploid" embryos stand a chance? I was wondering if I could maybe implant any, and if yes can I implant more than one at a time? Thank you :) 1.… — Tina F.

Dr. Geoffrey Sher answered

If any are"mosaic" they could auto correct in the uterus. Discuss with your RE. EMBRYO MOSAICISM: WHAT IS IT AND WHAT ARE THE CONSEQUENCES? Geoffrey Sher MD Human embryo development occurs through a process that encompasses reprogramming, sequential cleavage divisions and mitotic chromosome segregation and embryonic genome activation.…
IVF Failure & Pregnancy Loss Mar 4, 2023

Multiple IVF fails

Hi Dr. Sher thank you for your time. I’m 45 mother of 2 -18 &17 yr olds(normal pregnancies) I been doing IVF for the past 3 years. I’m currently on my 8th treatment with sperm & egg donor. I’ve had… — Ashley T.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
Age & Fertility Mar 4, 2023

Low ovarian reserve

Hi, for women age 41+ with low ovarian reserve what are options to conceive successfully using own eggs? I've been discouraged with clinic's pushing donor eggs and I am looking for a specialist that can help someone like me. Any… — Newbie F.

Dr. Geoffrey Sher answered

It is primarily the egg (rather than the sperm) that determines the chromosomal integrity (karyotype) of the embryo, the most important determinant of egg/embryo competency”. A “competent” egg is therefore one that has a normal karyotype and has the best potential to propagate a “competent” embryo. In turn,…
Early Pregnancy & hCG Feb 28, 2023

Hcg levels

My hcg level went from 1058 to 3857 in 48 hours. Is that normal. Should I be worried about a molar pregnancy or Down syndrome? — JoAnn D.

Dr. Geoffrey Sher answered

I doubt this is a "molar' pregnancy but it could be a "multiple gestation". Measuring and interpreting Blood hCG to Assess Pregnancy Viability Following ART Treatments. Geoffrey Sher MD I know of no medical announcement associated with the degree of emotional anticipation and anguish as that associated with…
IVF Failure & Pregnancy Loss Feb 27, 2023

2 Implantation failure

I had 2 FET with 2 A grade embryo so each time but failed. No undying issues other than mild PCOS. chosen IVF due to male infertility low motility and 1% morphology. Please help me. I got the immunology tests… — Rakshitha R.

Dr. Geoffrey Sher answered

There are only t 4 Reproductive Immunology Labs in the US that in my opinion, can do the immune tests adequately. If these were not used, the results are probably erroneous. Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant…
Hormones & Ovulation Feb 26, 2023

IVF failure 1x

I just went through my 1st IVF transfer on 2/15/23, I have found out I failed. My uterus lining was 9+ , Embryo was 4AA. I am wondering if it’s my natural killer cells. I had Endometriosis and a Septate… — Marisa T.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
Immunology & Implantation Feb 26, 2023

Prednisone/Blood thinner

We are adding prednisone and Lovenox to my protocol next transfer. When is the best time to begin each of these- in relation to the transfer? For example, before transfer, day of transfer, after positive test? — K M.

Dr. Geoffrey Sher answered

10-14 days prior to transfer.! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS) “ http://sherfertilitysolutions.com/sher-fertility-solutions-ebook.pdf…
Early Pregnancy & hCG Feb 26, 2023

Pregnant

Can I drink pregomega plus along with clean and baby aspirin 17 weeks pregnant — Shoneez V.

Dr. Geoffrey Sher answered

Yes you can! Geoff sher
Uterine & Endometrial Health Feb 24, 2023

**correction ** progesterone levels after FET

I need to edit my previous post that my PIO dose was 50 mg once daily prior to FET then dropped to 12.5mg after P levels were checked day after FET — Lauren C.

Dr. Geoffrey Sher answered

Same answer! Geoff Sher
Uterine & Endometrial Health Feb 24, 2023

Progesterone levels after FET

Hi Dr SHER, my clinic’s FET protocol has me on both progesterone vaginal capsules 200mg 3x/day plus 100mg PIO once daily in preparation for FET. They tested my levels day before transfer and was good; they tested day after and… — Lauren C.

Dr. Geoffrey Sher answered

I strongly doubt any adverse effect! Good luck! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions…
Embryos & Genetic Testing Feb 24, 2023

Recurrent Miscarriage

After four losses (ages 23, 32, and 33) I was diagnosed with one copy of PAI-1 and one copy of MTHFR. I also have very high thyroid antibodies. Could all of this be causing the losses? We are moving on… — Mary P.

Dr. Geoffrey Sher answered

I doubt that the heterozygous PAI-1 and one copy of MTHFR can explain the losses. the thyroid antibodies is however another matter ...see below. Geoff Sher Between 2% and 5% of women of the childbearing age have reduced thyroid hormone activity (hypothyroidism). Women with hypothyroidism often manifest with…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Latest answers

Location

Follow Us