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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

  • Dear Patients,

    I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

    – Geoffrey Sher, MD

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Search 1,006 questions patients have already asked, or narrow them by topic.

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  1. Embryos & Genetic Testing

    Opinion on french MatriceLab test

    Dear Dr. Sher, Thank you for the detailed article on immunological issues of embryo implantation failures. I'm writing to you as a fertility patient in France. After a certain number of blastocysts transfered with a single implantation and early miscarriage,… — Manon G.

    Dr. Geoffrey Sher answered

    I aplaud any research that serves to uncover the immunologic basis for implantation dysfunction. Endometrial local immunity is likely an important parameter that influences implantation and the the prognosis of pregnancy.. Diagnosis of an endometrial immune dysregulation . It seeks to assess embryo-endometrial interaction and focuses on several…

  2. Embryos & Genetic Testing

    Recurrent implantation failures

    Dear Dr. Sher, Myself and husband are both 38 yrs old started our fertility journey at the age of 32 yrs so trying to conceive for 6 yrs now. We started with ovulation induction, had an ectopic treated with methotrexate.… — Remy A.

    Dr. Geoffrey Sher answered

    Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success…

  3. Embryos & Genetic Testing

    Vitrification of embryos

    Dear Dr. Sher, do you have experience with the freeze of day 4 embryos (morulas)? My clinic is suggesting that we freeze all remaining embryos on day 4 after transfer on same day, because day 5 is a Sunday and… — Cathryn L.

    Dr. Geoffrey Sher answered

    Frankly, I prefer to go to blastocyst just to have more confidence in embryo viability, however, transferring as morula isa acceptable. Geoff Sher Geoff Sher

  4. Egg Health & Ovarian Reserve

    Changes to a 4th cycle

    I’m at a bit of a loss. Having ICSI for secondary infertility (1st child conceived naturally age 29) and just midway through my 3rd cycle. I have paid up for a 4th cycle already so I’m keen to get some… — Amy E.

    Dr. Geoffrey Sher answered

    WE would need to discuss this complex matter. I suggest you call my assistant, Patti Converse (702-533-2691 and set up an online consultation with me. Geoff Sher PLEASE SHARE THIS WITH OTHERS AND HELP SPREAD THE WORD!! Herewith are online links to 2 E-books recently co-authored with my…

  5. Embryos & Genetic Testing

    Haploid

    What could cause a day 7 BB blastocyst that was fertilized via ICSI to be haploid (PGT-A results)? — Addison J.

    Dr. Geoffrey Sher answered

    It is likely "incompetent". Geoff Sher

  6. Egg Health & Ovarian Reserve

    Advice for last IVF round

    Dear Dr. Sher: Thank you for hosting this forum. I am just shy of 41 with social infertility and have had two failed IVF cycles. The first used an antagonist protocol at 300 IU gonadotropin and resulted in one whole… — Claire C.

    Dr. Geoffrey Sher answered

    Please read what follows and thereupon, might I suggest that we talk . Please call my assistant. Patti at 702-533-2691 and set up an online consultation with me to discuss. The journey of in vitro fertilization can be a rollercoaster of emotions for many patients. Often times they…

  7. Embryos & Genetic Testing

    FET canceled due to a yeast infection (vaginal candidiasis)

    My fresh embryo transfer was canceled two days before the procedure due to a yeast infection (vaginal candidiasis), and I’m wondering why this infection may have occurred. I haven’t had sexual intercourse or done anything specific that I believe could… — Hannah A.

    Dr. Geoffrey Sher answered

    In my opinion there is no reason to cancel FET because of a yeast infection. Geoff Sher

  8. Egg Health & Ovarian Reserve

    Bad quality eggs

    Dear Dr. Sher. I am out of options i feel. Unknown fertility problem, endometriosis. I am now 30 years old. For the last 5 years: 5 IVF/ICSI cycles, 65 mature eggs, 30 fertilized, 0 good blastocyst, only poor quality, nothing… — Maggy M.

    Dr. Geoffrey Sher answered

    Embarking on the journey of IVF often raises questions about the likelihood of success and the quality of embryos. While it’s challenging to predict outcomes due to various factors, there’s hope and information to guide you. Firstly, the key to fertilization potential lies in the chromosomal integrity of…

  9. Egg Health & Ovarian Reserve

    It’s over

    Dear Dr. Sher, I am 43 years old, and in the last 2 years: 6 cycles, 100 follicles, 90 oocytes collected, 60 oocytes matured, 50 embryos, 10 blastocytes, 1 euploid. One abortion (prior to ivf), two failed transfers (the euploid… — Anne C.

    Dr. Geoffrey Sher answered

    I think we should talk first before you make that determination definitively. If you are interested in having an online consultation with me, please contact my assistant, Patti Converse at 702-533-2691 or email her at concierge@sherivf.com\ Geoff Sher ADDRESSING ADVANCING AGE AND DIMINISHING OVARIAN RESERVE (DOR) IN IVF…

  10. Embryos & Genetic Testing

    Treatment for immune issues and euploid RPL

    Hello, I am a 32 y/o in Canada with history of 3 euploid miscarriages. First pregnancy embryo stopped growing 6.5 weeks, second pregnancy was a MMC of a blighted ovum, third pregnancy mono/mono twins resulted from a single embryo, both… — Anastasia S.

    Dr. Geoffrey Sher answered

    Respectfully, your immunologic implantation dysfunction is likely due to an alloimmune cause and if so would require different treatment (see below and read the E-books presented below ). I suggest you call my assistant, Patti Converse and set up an online consultation with me to discuss your case…

  11. Embryos & Genetic Testing

    Failed FET

    Hi Dr. Sher, You did my egg retrieval 3 years ago, and we welcomed our beautiful daughter 2 years ago. We just did another transfer of 1 pgt embryo for a baby boy, and it failed. We only have 1… — Megan L.

    Dr. Geoffrey Sher answered

    We should talk. Please call my assistant, Patti (702-533-2691) and set up an online consultation to discuss. Geoff Sher

  12. Embryos & Genetic Testing

    PGT-A results

    Dear Dr Sher, I have listened with interest to your interviews on The Egg Whisperer and I hope you won’t mind my reaching out. I am a 46 year old woman from London, UK. I began IVF treatment with my… — Belle E.

    Dr. Geoffrey Sher answered

    There is no point in holding on to a "complex aneuploid embryo". You should discard it , in my opinion. There can be a very rapid decline in AFC at your age . This is because of inevitable decline in ovarian reserve and in egg quality. If you…

  13. Embryos & Genetic Testing

    My embryo segmental abnormal

    I worked with you about 3 years ago. Thank you for helping us to our dream daughter. We are forever grateful. My question is about another embryo I would like to transfer . This is how it’s labeled, 46,XX,del(4)(q22). In… — Haley P.

    Dr. Geoffrey Sher answered

    Wonderful hearing from you...You made my day! I invite you to call 702-533-2691 and ask my assistant, Patti Converse, to set up an online consultation with me to discuss. Geoff Sher PLEASE SHARE THIS WITH OTHERS AND HELP SPREAD THE WORD!! Herewith are online links to 2 E-books…

  14. Embryos & Genetic Testing

    PGT-A

    Dear Dr Sher, I have listened with interest to your interviews on The Egg Whisperer and I hope you won’t mind my reaching out. I am a 46 year old woman from London, UK. I began IVF treatment with my… — Belle E.

    Dr. Geoffrey Sher answered

    If the embryo is aneuploid, there is no merit in keeping it. Frankly, trying with own eggs at 45y with such severely diminished ovarian reserve is ill-advised. You need an egg donor. ADDRESSING ADVANCING AGE AND DIMINISHING OVARIAN RESERVE (DOR) IN IVF Understanding the impact of age and…

  15. Embryos & Genetic Testing

    FET for women over 45

    Hello! I wanted to see if your fertility office has a maternal age limit to transfer frozen embryos? I am 49 and have two frozen embryos that were frozen when I was 36. My current fertility clinic will not continue… — Barb J.

    Dr. Geoffrey Sher answered

    Absolutely no such age limit! Two decades ago, when women went through IVF (in vitro fertilization), they usually had their embryos put in the uterus right after the eggs were collected in the same cycle (known as "Fresh" Embryo Transfer). Freezing embryos at that time was risky, with…

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