Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

Search the answers our doctors have already given

Fill in the following information and we’ll get back to you.

Answers from our doctors

Search 1,017 questions patients have already asked, or narrow them by topic.

179 answers

Clear all

Embryos & Genetic Testing Nov 14, 2022

steroids for raised TH1/TH2 assay

I had my first child with no difficulty. followed by 3 losses due to chromosomal issues then went to IVF and had 1 successful birth! We have been trying for the last 4 years and it has resulted in 2… — Tasnem A.

Dr. Geoffrey Sher answered

Your raised TH1: TH2 suggests activated uterine natural killer cells. In your case, having had a child already, this suggests that it is alloimmune rather than autoimmune, immunologic implantation dysfunction (IID). This would require a different approach to treatment. First, however you need to establish a diagnosis. We…
Embryos & Genetic Testing Nov 7, 2022

Permutation Fragile X

I have have had 2 pregnancies, 1 resulted in miscarriage and the other resulted in mono-di girls. I am a permutation fragile x carrier and they have the gene as well. Myself and my husband would like to go through… — Randi T.

Dr. Geoffrey Sher answered

The answer to both questions is yes! Fragile X syndrome occurs in individuals who carry the gene, FMR1 on an X-chromosome. This condition is inherited as a dominant X-linked disorder. With a dominant disorder, the condition results when there is only one copy of the altered gene in…
Early Pregnancy & hCG Nov 7, 2022

Recurrent early pregnancy loss

Dear Dr Sher, My husband and I (both 35) have a severe male factor as well as lean PCOS. Despite this we had great fertilization and blastocysts rates in our IVF-ICSI with beautiful AA and BB embryos. Meanwhile we had… — Katrina S.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost within 10 weeks of conception (in the…
Immunology & Implantation Oct 21, 2022

Partial DQ apha and NK cells

Dear Doctor Sher, After many years of trying and 13 chemical pregnancies finally I did some immune tests this month: (Partner) 01.02 02.01 (Me) 01.02 01.02 19 17.9 (H) (2.00 - 12.00) 19 +cells 5+ 11.3 (H) (5.00 - 10.00)… — Ola K.

Dr. Geoffrey Sher answered

WE really do need to talk! Please call Patti Converse (my assistant, at 702-533-2691 and set up an online consultation with me. You have a partial DQ alpha match with your husband. This is only significant if in addition, you have activated NK cells (which needs to be…
Immunology & Implantation Oct 11, 2022

Recurrent miscarriage

Hi Dr Sher, I wish you had never left South Africa, as that is where I am from. I am 33 years old, we went to do ivf as my fiance is paralysed. He was placed on meds to improve… — Yvonne W.

Dr. Geoffrey Sher answered

I really sympathize with your predicament but there is no substitute for an appropriate and comprehensive medical evaluation of your problem....especially when it comes to an evaluation of immunologic implantation dysfunction. I urge you to download a free copy of my E-book , “Recurrent Pregnancy Loss and Unexplained…
Embryos & Genetic Testing Sep 13, 2022

Implantation failure

Hi Dr Sher. I am from New Zealand and almost 2 years on in my fertility journey. I’m 42 now and have 3 children of my own. My husband has 1. We are both fit and healthy. I’ve always had… — Barbara C.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
Immunology & Implantation Sep 8, 2022

Infertility for 14 years

Hi, we have been facing recurring losses, dq alpha complete match, nk cells causing allergic reactions at the time of implantation. Is there anything you can suggest for us to be pregnant. I'm 40 and my husband 39, we don't… — Shama S.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost within 10 weeks of conception (in the…
Early Pregnancy & hCG Sep 8, 2022

Test

What test would you consider if someone had 4 miscarriages before 6 weeks I have done all the basic test Immune conditions Chromosome Ovarian reserve My husband sperm Protein Std Everything is normal No polyps I do have fibroids not… — Medjine E.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost within 10 weeks of conception (in the…
Embryos & Genetic Testing Aug 28, 2022

IVF transfer failure

Hi! I would like to book a consultation and consider next steps. I did two precision IVF and the transfer failed. Genetically normal embryos. I’m trying to figure out if seeing a RI would be worth it. I’m open to… — Gloria K.

Dr. Geoffrey Sher answered

When women with infertility due to endometriosis seek treatment, they are all too often advised to first try ovarian stimulation (ovulation Induction) with intrauterine insemination (IUI) ………as if to say that this would be just as likely to result in a baby as would in vitro fertilization (IVF).…
IVF Failure & Pregnancy Loss Aug 15, 2022

failed ivf

i'm 40 years old,my AHM is 0.89. i was undergoing an ivf which failed. they got 6 eggs,5 mature,i embryo was slowly groing ending up not sticking after transfering. later the doctir told me they examined my eggs and came… — Tammy S.

Dr. Geoffrey Sher answered

It is primarily the egg (rather than the sperm) that determines the chromosomal integrity (karyotype) of the embryo, the most important determinant of egg/embryo competency”. A “competent” egg is therefore one that has a normal karyotype and has the best potential to propagate a “competent” embryo. In turn,…
IVF Failure & Pregnancy Loss Aug 12, 2022

Ivf failure and suspect endometriosis

Hi Dr Sher I have been trying to conceive for 3 years now with no success. I've recently had 1 failed ivf cycle where I began bleeding 7 days post embryo transfer. Which I believe is implantation failure. I have… — Isma B.

Dr. Geoffrey Sher answered

often advised to first try ovarian stimulation (ovulation Induction) with intrauterine insemination (IUI) ………as if to say that this would be just as likely to result in a baby as would in vitro fertilization (IVF). Nothing could be further from reality It is time to set the record…
Cost & Insurance Aug 9, 2022

Family Balancing

[et_pb_section fb_built="1" admin_label="section" _builder_version="4.16" global_colors_info="{}"][et_pb_row admin_label="row" _builder_version="4.16" background_size="initial" background_position="top_left" background_repeat="repeat" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.16" custom_padding="|||" global_colors_info="{}" custom_padding__hover="|||"][et_pb_text admin_label="Text" _builder_version="4.16" background_size="initial" background_position="top_left" background_repeat="repeat" global_colors_info="{}"]Hello. I am writing today to inquire about your services. I am 36 years old. I have 2 healthy… — Jacqueline S.
Hormones & Ovulation Aug 4, 2022

Surge on day 15 with 14mm follicle

Hi Dr.Sher, I am doing an investigative cycle through my fertility clinic this month. Yesterday was my day 15 and on ultrasound I had a dominant follicle measuring 14mm. It was growing at a rate of 1mm per day since… — Elona K.

Dr. Geoffrey Sher answered

The most likely explanation is that when (on day 15 the 14mm follicle was seen, ovulation had already commenced!
Early Pregnancy & hCG Aug 4, 2022

High risk pregnancy

Hello Dr. Sher, I can only imagine how busy you are so I will try to make this question as brief and concise as possible. I just turned 39. Currently 5wks pregnant (naturally conceived--was told it was an impossibility by… — Kristine S.

Dr. Geoffrey Sher answered

I am so happy for you. The fact that you have had 2 children with this underlying autoimmune condition, suggests that you are of the50% of women who have thyroid antibodies but do not have activated uterine natural killer cells. If so, this pregnancy could be safe. Besides,…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

179 answers

Location

Follow Us