– Geoffrey Sher, MD
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Name: Olga M.
Hi Dr. Geoffrey Sher,
I have a question regarding IVF.
I have high TPO ( 4,843)but my TSH and t4,t3 are at normal level.
Should I start IVF procedure ( my AMH is 0.053)and I am 39.
Your advice will be appreciated.
Thank you for your time and help.
Between 2% and 5% of women of the childbearing age have reduced thyroid hormone activity (hypothyroidism). Women with hypothyroidism often manifest with reproductive failure i.e. infertility, unexplained (often repeated) IVF failure, or recurrent pregnancy loss. The condition is 5-10 times more common in women than in men.
In most cases hypothyroidism is caused by damage to the thyroid gland resulting from of thyroid autoimmunity (Hashimoto’s disease) caused by damage done to the thyroid gland by antithyroglobulin and antimicrosomal auto-antibodies. The increased prevalence of hypothyroidism and TAI in women is likely the result of a combination of genetic factors, estrogen-related effects and chromosome X abnormalities.
While being the main cause of hypothyroidism TAI is more often present independent of coexisting clinical or hormonal features of hypothyroidism. Regardless of whether or not hormonal or clinical evidence of hypothyroidism is present or whether a woman with Hashimoto’s disease is successfully treated with thyroid hormone supplementation, women who have thyroid antibodies are often afflicted with reproductive dysfunction (infertility and early or late pregnancy loss).
We reported on the fact that 47% of women with TAI (regardless of the absence or presence of clinical hypothyroidism) have CTL and activated NKa cells and that such women often present with reproductive dysfunction. We also reported that appropriate treatment with IL and steroids, often results in viable pregnancies in such cases.
The fact that almost 50% of women who harbor antithyroid antibodies do not have activated CTL/NK cells suggests that it is NOT the antithyroid antibodies themselves that cause reproductive dysfunction. The activation of CTL and NK cells that occurs in half of the cases with TAI is probably an epiphenomenon with the associated reproductive dysfunction being due to CTL/NK cell activation that damages the early “root system” (trophoblast) of the implanting embryo.
Geoff Sher
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Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)……. for your reading pleasure:
If you are interested in having an online consultation with me, please contact my assistant, Patti Converse at 702-533-2691 or email her at concierge@sherivf.com\
Name: Jeimy Castillo
Quiermasinformacion
Please repost in English
Name: Gabriel Carrillo
Es algo serio
Please post in English!
Geoff Sher
Name: Remzi Hobson
Hi,
I was born at your clinic, and I am reaching out to request any records regarding my biological mother. I also have a twin sister.
Please let me know what information you require from me to assist in this matter. I appreciate any help you can provide.
Remzi Mustafa
Son of Timur Mustafa
Born on 17/10/2006
I do not know the date of conception. However, I was two months premature when I was born, which may be helpful.
Best regards.
I am no longer at the clinic where you were conceived. If you send me details of where and when you were conceived, I will do my best to provide you with more specific information.
Good luck!
Geoff Sher
Name: Lázaro Dibut
Vivo en Kentucky
Please re-post in English!
Geoff Sher
Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)……. for your reading pleasure:
If you are interested in having an online consultation with me, please contact my assistant, Patti Converse at 702-533-2691 or email her at concierge@sherivf.com\
Name: Rodrigo Pereira
I want to be a donor, but when I access it, it says egg donations, what can I do to donate sperm?
You would need to research where sperm banks are located in your area and reach out to them!
Good Luck!
Geoff Sher
