Ask Our Doctors
Dear Patients,
I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.
– Geoffrey Sher, MD
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My wife was diagnoses last year with Adenomyosis after having a miscarriage, and had a DNC. We’ve been having trouble getting pregnant ever since, and would like to know all options. We saw this on a show, and wondering if this is another option. Thank you.
Hello, I am a healthy, active 34 year old who has been trying to conceive for 5 years. I’ve had 5 PGT tested embryos transferred with 4 implantation failures and one a very low chemical. One healthy embryo and one low mosaic embryo left frozen. Laparoscopy and hysteroscopy shows no issues. Current doctor has told me surrogacy or adoption is my best next step. Have you treated cases similar to mine with success? Or would you give me the same recommendation?
I am doing my first FET prep cycle – I am on oral estrogen (2mg) and estrogen patches (0.1mg/day) I started at 2 patches and 1 pill per day and then gradually bumped up to 3 pills and 3 patches per day. During STIMs, my lining was beautiful and I had no problems with fluid. Now after two weeks at my lining check, my lining was 6.6mm and I had a little less than 2mm of fluid in my lining. My Estrogen level was also 479 (again at two weeks of estrogen prep) I have no tubal factors, or any of the reasons this could happen that I find when I Google why fluid occurs. My doctor said some people’s body just don’t like the estrogen – but I did fine during STIMs and my estrogen level was higher than 2000. Why is this happening and what can be done to correct it? Will injectable estrogen work better for me?
Hello Dr. Sher I’ve been seeing Dr. Paschall here in Franklin TN, I believe she has been speaking with you about my case. I have had 20 missed/miscarriages over a 14 year span with my spouse but I have two children from a previous relationship. I’ve miscarried all around the same time frame with is around 8 weeks each time. Fetal detection would be detected with a strong HR of 130-156 range then follow up again and no fetal HR. I’ve had a full work up Fertility Specialists here and Reproductive Endocrinologist out of state no success. I have MTHFR and PCOS. I was told I may have IID and may require Plaquenil for the first 12 weeks. My GYN wants to see about a Telehealth visit with you and hopefully she can monitor me here with you recommendations to help me achieve a successful healthy full term pregnancy. Please Advise. Thank You!
Hi There,
I had 12 ‘healthy’ embryos from 2 retrevials . NO natural cycles all with. Progesterone, Esradiol, Prednisone, Baby Aspirin
Did 3 transfers for these . 1st failed. – did ERA came back normal. 2nd. B.O. – needed two D+C to remove tissue , 3rd – Pregnant and lost daughter 25 weeks due to TMFR as Labor+Delivery, she had skeletal and dev issues = 12MB missing of 2nd chromosone, had septic shock post delivery + 3 months later D+C as left tissue behind . – waited 5 months, 4th transfer- with Lovenox – failed – Another ERA-ordered came back normal. 5th transfer- Lovenox + Lipid infusions – chemical pregnancy.
NOW new doctor. Did another retreival, have another 12 embryos from Day 5 and 6 (all 4AA,4AB,5AA,5AB) + Hysteroscopy to make sure NO scarring -came back clean. not testing embryos since Husband and I not carriers and now beleive in Amnios better (based on our history) Doctor suspects embryos fragile to testing . NOW wants to do a receptiva pre transfer incase positive…NO other signs of ENDO except all fertility challenges.
Have done full blood failure panels – nothing abnormal inlcuding no NKAS’s etc.
ANY THOUGHTS?
Hello
I read your blog and love the content.
I am 36yrs old woman (AMH 29 pmol/L, AFC 14-20), obesity (BMI from 31-34 in the last year, used to be much more).
My DHEA, testosterone, PRL were normal/low-normal/mid-range…
FSH 7 and LH 6.6 (Nov 2022).
I am freezing eggs due to need for
high dose chemotherapy for lupus/Sjogrens.
I did 1 cycle and got 9 mature eggs (10 were retrieved, i was not sedated so the RE stopped at 10 eggs due to high pain, although there were 4 more folicules).
It was antagonist protocol with 150 Elonva, 6x 0.25 orgalutran and 450 Pergoveris, and the trigger was rHCG 250 (Ovitrelle).
After low to low normals dhea/testosterone levels i started supplementing DHEA with 50 mg a day and HGH for just few days 1 IU a day.
Repeated tests showed slightly increased DHEA -s and testosterone.
I dont know should i continue supplements or reduce?
I am worried about egg quality.
Thing is my new labs show FSH 6.6 and LH 3.6 , testosterone, and DHEA a bit high as mentioned, and progesterone high (i took duphastone after eggg retrieval cycle for cyst).
My worry with taking DHEA, HGH, is the 10% increased levels i had now but more importantoy it is that I had once “microcystic ovaries” but that was 5+ yrs ago and now multiple ultrasounds show nothing Like PCOS, and also my hormones prior to supplementing were on the lower end (DHEA, testosterone) and LH/FSH ratio was a bit under 1.
I dont know if the recent LH number is relevant or reduced from progesterone.
Can taking HGH also be a problem same like DHEA when possible PCOS (or history of it)?
Because in the past when i was more obese my testosterone was also a bit high.
any opinion would be helpful
Thank you
Hello Dr. Sher,
I am a patient working with an IVF Clinic that holds 2 more of my PGT-A Euploid Embryos (using Donor Eggs and my husband’s sperm), but we have unfortunately arrived at a crossroads where my smaller clinic is unable to move forward with me. The issue being FET Implantation Failure which is “somewhat” explained by some extensive genetic testing and an Endometrial Biopsy/Receptiva Test. The two tests revealed that I have NK Cells, Inflammation/potential Endometritis , presence of BCL-6, (though I have no symptoms of Endometriosis). Wondering if you offer Reproductive Immunology as a Separate Specialty/Service or if you have to presently be doing IVF cycles with Sher Fertility?
We had 20 eggs at Day 3, 10 of which were grade 1 or 2, the rest were grade 3 or 4. By Day 5 we only had 1 blastocyst of 4BB quality. What would cause such a high loss from Day 3 to 5?
Hi Sir,
On 12th Day of period i have done TVS and one 30x23mm, one 16mm and 3/4 other smaller follicle on my right ovary.
Will i be able to conceive with these?
Thanks
Hello, I am considering treatment at a new clinic after a disappointing first attempt at IVF. I am 46 years old and tried using my own eggs. From my last blood test some two months ago I had an AMH of 0.98 ng/ml or 7 pmol/l and took pergoveris for the ovarian stimulation (300 units/day) for 9 days before the trigger on day 10. I had 15 eggs retrieved and 13 of those were mature enough to be fertilised, then 7 were fertilised, and 3 got to blastocyst stage but sadly the PGA-T testing showed the three embryos to be aneuploid. Given the relatively high quantity of eggs, do you think it’s realistic to try a second cycle or simply a waste of money, and I should try a donor egg instead?
Thank you in advance for your response.
Hello!
I am wondering what the process would be to book in for a frozen transfer this coming fall/winter. I currently have embryos stored in New York, Would it be possible to book a call with either Dr. Sher or a nurse from the New York clinic to discuss? (I had a successful pregnancy from a frozen transfer done last January. My son will be 1 as of Sept 25th)
Thank you very much!
– Brittany Minchin
If two untested embryos are transferred & one is a normal embryo, the other is abnormal – does the abnormal embryo ‘kill off’ or damage the normal embryo? Thanks 😉
Hi, I have what appears to be a 7cm endometrioma on my left ovary. I had surgery to remove an ovarian cyst on the same ovary a year ago and it regrew to the same size within 4 months. An interesting side note is that they tested my last cyst and there were no endometrial cells found, even though the cyst was filled with old blood. They are still calling my new cyst an endometrioma, even though they are not sure it actually is one. My GYN is now suggesting surgery to remove the entire ovary because it regrew so quickly. I would like to avoid surgery if at all possible because I had complications during my last one. Do you offer the ovarian sclerotherapy procedure? If not, do you know who would?
My amh is 20 and now I am into iui treatment. My follicle size is 23mm in right ovary and left ovary pcos . My egg is not rupturing after taking injection also..
My husband and I are both 29 years, we’ve been trying to conceive since two years and we’ve started visiting a fertility clinic since 11/2022. We’re both healthy, have no other health issues.
Later in March-2023, my AMH fell to 0.79. In April, we decided to move on to IVF due to my falling AMH. April-2023 Ivy cycle 1 AFC: 11, FSH:6, E2:40 We got 10 follicles, 8 mature eggs Day 2, 3: 6 No blastocysts on day5, day 6 ending we had 3 blastocysts.
The doctor and the embryologist said the growth till day 3 was on track, and slowed to a great extent post that indicating that the embryos might not implant or lead to live birth. We decided to check my husbands DFI and do TESA and PICSI. DFI was 34%.
Ivy cycle 2 FSH: 9.7, E2:22 AFC: 8 SA: all parameters normal, morphology: 1% We got 6 follicles and 6 mature eggs. Day2: 5. Day3: 4. They froze 2 day 3 embryos No blastocysts on day 5 and b/c graded blastocysr on day 6 which doctor said they can’t discard. This cycle, we did TESA + PICSI.
We’re confused to see the same results both these times. What can we do differently the next time and how can we improve our chances?
Hello Dr. Geoffrey Sher and team,
We are looking for fertility specialists that can serve our private patients from the Jewish Community in the state NY.
Normally we do a face-to-face meeting, however under the new circumstances I would like to set up a meeting with in person to better understand the services you provide and explain to you in detail about our patients, why they are using our services, and how we generate them.
In a glance, we connect local businesses to the Jewish Community in 17 states, since 1989.
We are in demand for a fertility specialists that can take new patients starting in August.
Please let me know when we can have a meeting.
Best to start with a phone call 😊
My cell-347-944-9146
Have a fantastic day!
Me and my husband been trying to
Get pregnant and I want to see if I can get tested to see why I am not getting pregnant because we have been trying for months