Managing Unexplained Infertility: A Rational Approach
Infertility affects 10%-15% of couples who are unable to conceive. In some cases, the cause of infertility cannot be determined using conventional diagnostic methods,…
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Ten years of writing on IVF, fertility and reproductive medicine from Sher Fertility Solutions. Ten years of writing on IVF and fertility.
Understanding Recurrent Pregnancy Loss (RPL): Causes And Solutions
When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in…
Endometriosis and Infertility: Rational Treatment Offers Real Hope!
Endometriosis is a condition where the lining of the uterus grows in other places besides its usual spot inside the uterus. It can affect…
IVF Failure With “Normal” Embryos: Examining and Addressing Anatomical and Immunologic Causes
Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there…
Embryo Implantation Dysfunction: Causes, Diagnosis & Care
Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent…
Disruption in the relationship between KIR, HLA, and NK cell activity and embryo implantation dysfunction: how to assess this
I constantly receive inquiries from “confused” patients with unexplained recurrent IVF failure , unexplained infertility, recurrent pregnancy loss etc. (where an immunologic implantation dysfunction…
Treatment of Recurrent Pregnancy Loss (RPL) due to Alloimmune Implantation Dysfunction : Comparing cases with a “Partial” versus a “Complete” Match (rare)
All humans have two DQ-alpha genes, one of which is contributed by the father and the other by the mother. In a small…
Hereditary Clotting Defects (Thrombophilia)
Thrombophilia (Hereditary Clotting Defect) is defined as the genetic predisposition to developing intravascular thrombosis. It is due to hypercoagulability of blood leading to…
Immunologic Implantation Dysfunction (IID) -Making the Diagnosis
Currently there are fewer than a dozen immunology reference laboratories in the U.S that are capable of analyzing the required elements with a sufficient…
Immunologic Implantation Dysfunction (IID): Treatment
In the United States, effective treatment of NK/CTL activation associated with either alloimmune or autoimmune implantation dysfunction requires the administration of primarily Intralipid (IL)or…
Thyroid autoantibodies and Immunologic Implantation Dysfunction (IID)
Between 2% and 5% of women of the childbearing age have reduced thyroid hormone activity (hypothyroidism). Women with hypothyroidism often manifest with reproductive…
Immunologic Implantation Dysfunction (IID) & Infertility (IID): PART 1-Background
In 15-20% of women who have infertility or RPL, the cause will be immunologic implantation dysfunction (IID). Accordingly, all women who have predisposing…
IVF Failure & Recurrent Pregnancy Loss: Expert Insights
IVF FAILURE AND RECURRENT PREGNANCY LOSS WITH GUEST DR. GEOFFREY SHER Dr. Geoffrey Sher is an internationally renowned expert in the field of…
Diagnosing and Treating Immunologic Implantation Dysfunction (IID)
Central to making a diagnosis of an immunologic implantation dysfunction (IID) is a need for the appropriate interpretation of Natural Killer Cell Activity…
Immunologic Implantation Dysfunction (IID): Causes & Care
In the United States, effective treatment of NK/CTL activation associated with either alloimmune or autoimmune implantation dysfunction requires the administration of primarily Intralipid (IL).…
Immunologic Implantation Dysfunction: Importance of Meticulous Evaluation and Strategic Management: (Case Report)
Greetings Dr. Sher! Just wanted to first thank you for all that you do for women and infertility and I’m truly amazed and grateful…
Intrauterine Insemination (IUI): Who needs it and who does not; Pros and Cons
“As physicians we really need to seriously rethink the basis upon which we recommend IUI!” -GS Intrauterine insemination (IUI), the injection of sperm into…