Dr. Geoffrey Sher, Author at Sher Fertility Solutions | Begin Your Fertility Journey

Pros and Cons of The Lupron (Leuprolide) Trigger Shot

Traditionally, IVF egg retrievals are timed for about 36 hours after a
10,000U hCG “trigger”. The hCG hormone thereupon remains in the
system for up to a week. When patients who overstimulate following
ovarian stimulation
[https://blog.drgeoffreysherivf.com/ovarian-stimulation-for-women-with-diminished-ovarian-reserve-dor-and-in-older-women-undergoing-ivf/]
experience prolonged exposure to hCG have a risk of developing

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How Does Bodyweight Affect Fertility and IVF Outcome?

By Dr. Geoffrey Sher

The prevalence of obesity in Western societies is on the rise, which
has a profound effect on the reproductive performance of women who are
trying to have a baby. Recent evidence suggests that obesity in women
of reproductive age is associated with decreased birth rates,
increased miscarriage rates, lowered IVF success rates, higher rates
of premature delivery and a marked increase in pregnancy
complications. We use two parameters to measure height-weight …

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Premature Luteinization (“the premature LH surge): Why it Happens and how it can be Prevented

By Dr. Geoffrey Sher

Premature luteinization (“premature LH surge”) occurs when prior to
the planned initiation of the hCG trigger, a progressive rise in LH,
irreversibly compromises follicle and egg development and maturation.
It is not a sporadic isolated event. It comes as a culmination of a
series ovarian events, occurring mostly in susceptible women (i.e.
usually older women and those with diminished ovarian reserve. It is
more likely to occur when the protocol used for o…

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Induction of Ovulation With Clomiphene Citrate: Mode of Action, Indications, Benefits, Limitations and Contraindications for its use

By Dr. Geoffrey Sher

Clomiphene (Clomid, Serophene) is by far the most widely prescribed
agent for the induction of human ovulation for women who do not
ovulate, those with dysfunctional ovulation and women with
”unexplained” infertility. When used in young women (who have
adequate ovarian reserve) with these problems the viable pregnancy
rate is reported as being between 6% and 10% per cycle of treatment.
Aside from conventional ovulation induction, clomiphene has been us…

Induction of Ovulation With Clomiphene Citrate: Mode of Action, Indications, Benefits, Limitations and Contraindications for its use Read More »

Uterine Fibroids and Fertility

By Dr. Geoffrey Sher

Fibroids or leiomyomas are non-malignant muscle tumors that grow in
the uterine wall. They can be found in about one out of every five
(1:5) women >30Y of age. Fibroids are far more prevalent in African
Americans and women and less frequent in other ethnic groups (i.e.
Caucasians and Asians). Fibroids, enlarge and/or distort uterine
configuration. They can produce symptoms such as heavy, painful and
prolonged menstrua…

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Natural Killer Cell Activation (NKa) and Immunologic Implantation Dysfunction (IID) in IVF: The Controversy!

By Dr. Geoffrey Sher

“Innovators are rarely received with joy, and established
authorities launch into condemnation of newer truths; for at every
crossroad to the future are a thousand self-appointed guardians of the
past.”

Natural Killer Cell Activation (NKa) and Immunologic Implantation Dysfunction (IID) in IVF: The Controversy! Read More »

How Many Embryos Should be Transferred: A Critical Decision in IVF

By Dr. Geoffrey Sher

The decision on how many embryos to transfer confronts most IVF
physicians and their IVF patients. It is driven by a goal that both
share in common, namely that of optimizing the chance of IVF treatment
resulting in pregnancy. Clearly, the more embryos transferred, the
greater the likelihood of success. However, there is overwhelming
evidence to show that the more embryos transferred to the mother’s
uterus, the greater the risk of a multiple pregnancy re…

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Frozen Embryo Transfer (FET): A Rational Approach to Hormonal Preparation and How new Methodology is Impacting IVF

By Dr. Geoffrey Sher

Until about 15 years ago, we believed that the best and safest way to
cryopreserve embryos was by using a slow freezing method. What we
subsequently learned was that the slow freezing process caused the
formation of intracellular ice and that this, by damaging embryos and
compromised their post-thaw survival as well as IVF outcome,
significantly. The introduction of ultra-rapid embryo freezing
(vitrification) has changed all that. With vitrification, embry…

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Human Growth Hormone (Omnitrope) in IVF

By Dr. Geoffrey Sher

The term “Biological Clock
[/blog/the-biological-clock-and-how-it-should-influence-the-selection-and-design-of-ovarian-stimulation-protocols-for-ivf/]”
is used to define the time line for a woman’s reproductive
potential. It is affected primarily by two factors:

* Age:…

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Adenomyosis Related Infertility: A Therapeutic Challenge

By Dr. Geoffrey Sher

Adenomyosis is a condition where endometrial glands develop outside
the uterine lining (endometrium)
[/blog/viagra-treatment-thicken-uterine-lining/], within the muscular
wall of the uterus (myometrium). A definitive clinical diagnosis of
adenomyosis is difficult to make. The condition should be suspected
when a premenopausal woman (usually>25 years of age) presents with
pelvic pain, heavy painful…

Dr. Geoffrey Sher

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