Dr. Geoffrey Sher, Author at Sher Fertility Solutions | Begin Your Fertility Journey

Performing Embryo Transfer: The “Process”

Embryo transfer (ET) is undoubtedly a rate limiting factor in IVF. The
IVF doctor’s expertise in performing ET is one of the most important
factors determining IVF outcome. It requires the dexterity, skill, and
gentle touch that can only truly come through experience. Of all the
procedures in IVF, this is the most difficult to teach. It is a true
“art” and there is little doubt that many women will fail to
conceive following IVF from a suboptimal transfer technique. Good
quality em…

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IVF: Selecting the Best Quality Embryos to Transfer

By Dr. Geoffrey Sher

The numerical chromosomal configuration of a cell is referred to as
its karyotype or ploidy. A cell with an irregular chromosome number is
referred to as aneuploid while one with a normal karyotype, as
euploid. It is predominantly (but not exclusively) the chromosomal
configuration of the embryo that determines its subsequent ability,
upon reaching a receptive uterine environment, to propagate a normal
pregnancy, also referred to as its “competence.” A “euploid
(“co…

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A Case for Transferring Blastocysts on Day 5-6 Post-Fertilization Rather Than on Day 2-3 as Cleaved Embryos.

By Dr. Geoffrey Sher

_EMBRYO TRANSFER (ET) IS UNDOUBTEDLY THE SINGLE MOST IMPORTANT STEP IN
IVF. IT TAKES CONFIDENCE, DEXTERITY, SKILL AND TIMING TO OPTIMALLY
PERFORM ET. OF ALL THE PROCEDURES CONDUCTED IN IVF, EMBRYO TRANSFER IS
THE MOST DIFFICULT TO PERFECT. SADLY, FAR TOO MANY WOMEN FAIL TO
CONCEIVE SIMPLY BECAUSE OF POOR TIMING AND TECHNIQUE OF ET._
While the debate over whether it is better to transfer cleaved e…

A Case for Transferring Blastocysts on Day 5-6 Post-Fertilization Rather Than on Day 2-3 as Cleaved Embryos. Read More »

IVF And Diminished Ovarian Reserve (DOR): A Rational Basis for Selecting the Optimal Protocol for Ovarian Stimulation

By Dr. Geoffrey Sher

When it comes to the selection of ovarian stimulation protocols for
older women
[/blog/ovarian-stimulation-for-women-with-diminished-ovarian-reserve-dor-and-in-older-women-undergoing-ivf/]
and those who have DOR there is in my opinion, no justification for
the use of a “one size fits all” or “recipe approach”. I
firmly believe that th…

IVF And Diminished Ovarian Reserve (DOR): A Rational Basis for Selecting the Optimal Protocol for Ovarian Stimulation Read More »

Agonist (Lupron) Therapy in IVF

By Dr. Geoffrey Sher

All gonadotropin releasing hormone (GnRH) agonists
[/blog/gnrh-antagonists-ganirelixcetrotideorgalutron-ivf-ovarian-stimulation-protocols/]
act by rapidly expunging reservoirs of follicle stimulating hormone
(FSH) and luteinizing hormone (LH) from the pituitary gland. GnRH
agonists can be administered by intramuscular injection (e.g. Lupron,
Buserelin) or throug…

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A Fresh Look at The Indications for IVF

By Dr. Geoffrey Sher

Today, due to a myriad of factors, IVF is regarded as one of the main
thoroughfares for helping couples achieve the goal of creating a
family. However, no two IVF candidates are exactly alike and there is
no single approach that is applicable to every patient. In the final
analysis, success requires a careful analysis of the variables known
to affect outcome in combination with a very individualized and
customized approach to treatment, judicious and selective…

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Recurrent “Unexplained” IVF Failure with Good Quality Embryos.

By Dr. Geoffrey Sher

BACKGROUND: CJ, a 34-year-old, and her husband RJ, age 35) presented
to me with a six-year history of infertility
[/blog/the-causes-of-infertility/]. Based on semen analysis, RJ, who
had initiated two pregnancies in a prior relationship, was found to be
perfectly fertile. CJ had been married before and in that
relationship, had also experienced two years of infertility. Of
interest is the fact that …

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Endometriosis Presenting as “Unexplained Infertility”

By Dr. Geoffrey Sher

Background: “Jamie” consulted with me when she was 34 years of
age, after 3 years of failed treatment and a diagnosis of
“unexplained infertility
[/blog/unexplained-infertility-often-matter-diagnosis-overlooked/].”
A laparoscopy had revealed her to have mild (Stage 1)

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Why Did So Few of My Eggs Fertilize and Make it to Blastocyst?

By Dr. Geoffrey Sher

One of the commonest questions asked by patients undergoing IVF
[/blog/selecting-ivf-program-willingness-share-financial-risk-patients-builds-onfidence/]
relates to the likelihood of their eggs fertilizing and the likely
“quality of their embryos
[/blog/ivf-selecting-best-quality-embryos-transfer/]. This is also …

Why Did So Few of My Eggs Fertilize and Make it to Blastocyst? Read More »

Early Pregnancy Loss: Causes and a Rational Approach to Management.

By Dr. Geoffrey Sher

There is nothing more stressful to patients and to caring physicians
than dealing with recurrent early pregnancy losses (RPL)
[/blog/recurrent-pregnancy-loss-rpl/]. There is also no greater
imperative in such cases than to carefully identify the underlying
cause that without which successful treatment is far less likely. In
about 80% of cases, early pregnancy loss (whether due to miscarriage
or chemical pregnancy) is due to

Early Pregnancy Loss: Causes and a Rational Approach to Management. Read More »

Dr. Geoffrey Sher

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