Hi Dr. Sher,
I listened to the podcast on IUI with you and Dr. Aimee, the egg whisperer and I wanted to reach out to you in hopes of seeking your advice. I am a 34 year old who is “unexplained” and I normally ovulate on my own. All blood work has been normal for me except for high TPO antibodies which the doctor has had me on a low dose of levothyroxine for a while now. My husband has a normal semen analysis. We have been trying for 2 years and the first time we conceived back in October 2022, I was on letrozole for “superovulation” and ended up having two mature follicles one on each ovary and we just did timed intercourse that cycle, but I ended up having a missed miscarriage at 7 weeks. We decided to try on our own for several months after without taking letrozole and we were not having any luck. In August 2023 we decided to try IUI so we did letrozole and the trigger shot and it actually worked until it ended in a chemical miscarriage. We did two more rounds of IUI after that and have not had success.
Do you feel IUI is even worth pursuing a couple more times given that I ovulate on my own and my husband’s SA is normal? Did the letrozole help us conceive, could it have caused the miscarriages? Would it be the same success rate as if we just tried on our own without even taking letrozole? I am so confused and at a loss on what to try and how long I should keep trying before considering IVF. Thank you in advance for taking the time to read this.

Thank you,
Mallory