I am 30, my husband is 29. I was diagnosed with PCOS at 15. I had a miscarriage at age 20 at 8 weeks. Last year, I had three miscarriages (one at 6 weeks, 5 weeks and then at 4 weeks). During my work up last year, we did genetic testing. My results were positive for mosaic Turner’s syndrome. This was only positive in less than 50% of my sample. Based on that, we chose to go the route of IVF. I did a retrieval this past July and did PGTA testing. I had 16 eggs retrieved, 12 mature, 9 fertilized, 4 embryos, 3 were genetically normal- 1 was abnormal (mosaic).

In the mean time, we had a spontaneous pregnancy in August. Since then, we have lost the baby (at eight weeks). Based on my PGTA testing, the numbers aren’t awful, and 75% of my embryos were “normal”, one had a genetic abnormality- NOT the chromosome that is linked with Turner’s.

We have tested this tissue from my miscarriage and it showed three different types of chromosomal abnormlities (none of which were Turners related).

I have been on medications (metformin, inositol, CoQ10, prenatals) to improve egg quality for over a year now. When I got pregnant in August of this year, my TSH was high, so I have since been started on Synthroid and taken off of it for normal TSH levels. I take all of my medications religiously. I just don’t understand why this is happening. My husbands tests have all been prestine. I have had a coagulation work up through a naturopath that I saw last year in the midst of my miscarriages, which was normal.

My husband and I have since done ERA/ EMMA/ ALICE which came back normal. I also did the UTIMPRO which is came back unremarkable. I did the Receptiva test which showed the BCL6 as positive, but the CD138 was negative. My fertility team has since let me know that they suspect it is endometriosis.

I am naieve, I know nothing about endometriosis. I am incredibly new to this world. My fertility clinic has decided to move forward with 2 rounds of Lupron (so two months) with Letrozole with the plans to implant at the end of Feb.

Does this sound right? Does this sound like a solid course of action moving forward? Should I be asking for more investigation towards this “suspected” endo. Should I be talking to someone about having the lap surgery to confirm this diagnosis? I am just so lost.

My problem is, I would hate to implant my embryos and have it end up in this same situation, and waste our three healthy embryos. I am just hoping for some guidance.