Hi,

I have done 4 rounds of egg freezing at 3 different clinics.

First round- 30 follicles growing, 15 retrieved but only 6 mature. I believe I was triggered to early as the majority of eggs were less than 16mm on day of trigger (only 6 were above). 375 gonal f and trigger of ovitrelle.

Second cycle. New clinic. Less follicles growing, 8 retrieved, 7 mature. The eighth one was matured in the lab for 2 hours and became mature so they froze that too. Dosage changed daily based on bloods but was around 150 Fostimon and 150 Meriofert. Trigger 10000 gonasi.

I then moved to a clinic abroad as I’m an expat so chose a clinic closer to me than my home country (U.K.)

Third cycle- about 14 follicles growing, 12 retrieved, 7 mature. They froze the 5 immature ones as well and will thaw these earlier when I come to use them to see if they can mature in the lab. 300 gonal f and 150 menopur. Dual trigger of 0.2 decapatyl and 7500 hcg.

Forth cycle- 21 follicles growing, 14 retrieved, 8 mature. They have again also frozen the 6 immature eggs. 300 folliculin and 150 humog. Trigger 0.2 decapatyl and around 8000 hcg.

My AMH never stays consistent. It has gone from 8.2 to 6.4, to 2.9 and then up to 9.6. No doctor can suggest why my AMH fluctuates. Instead they said to focus on the fact I get around 7 mature eggs each cycle.

My first 3 cycles were completed at the age of 34. And my last cycle at the age of 35 and 2 months.

My questions:

Why am I getting so many immature eggs? Does this suggest that my egg quality is poor? Should I also be concerned about the quality of my mature eggs? I’ve been told they look good quality.

How likely is it that the immature eggs will mature after thawing? Was there any point in the clinic freezing them?

Will 28/29 mature eggs be enough to give me the best chances of at least two children. Ideally I always wanted more children but I guess I need to rely on also getting pregnant naturally to give me the best chances. Should I consider another round?

Why does my AMH fluctuate?

In an ideal world I would have liked to have frozen a couple of years earlier but Covid meant this wasn’t possible. So it left me doing my cycles at the age of 34/35.

Any professional insight you have would be greatly appreciated.

Many thanks,

Emma