The question
Dear Dr. Sher,
In 2 days, due to partial DQA match with my husband and weak positive LAD Im going to have LIT in Greece. There are 2 clinics with big differences in price. One does the transfer to my forearm after 48hrs culture and the other one which is more expensive within the same day.
From your experience which one: 48hrs or less than 24 hrs is appropriate for the LIT?
Thank you very much for your reply.
Answer from Dr. Geoffrey Sher
The subcutaneous injection of the male partner’s lymphocytes to the mother is thought to enhance the ability for the mother’s decidua (uterus) to recognize the DQ alpha matching embryo as “self” or “friend” and thereby avert its rejection. LIT has been shown to up-regulate Treg cells and thus down-regulate NK cell activation and thereby improve decidual TH-1:TH-2 balance. Thus there could be a therapeutic benefit from such therapy. However, the same benefit can be achieved through the use of IL plus corticosteroids. Besides, IL is much less expensive, and the use of LIT is prohibited by law in the U.S.A.
Geoff Sher
General information only, not medical advice for your own situation. For that, book a consultation.