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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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Embryos & Genetic Testing May 10, 2023

3 PGT Normal Implantation Failure.

Hello Dr. Sher, I just heard your interview about recurrent implantation failure on Dr. Aimee’s podcast. I am 33 years old, no known fertility issues, my husband and I are doing IVF with PGT-A/M for genetic purposes. I have had… — Alayna D.

Dr. Geoffrey Sher answered

Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or immunologic factors. IVF success rates…
Embryos & Genetic Testing May 9, 2023

Repeated implantation failure

I would like to find out ways in which I can maximize my ability to have a successful FET. I have had four (4) transfers with untested embryos and none of them implanted. I recently did a retrieval and I… — Tracey-Ann H.

Dr. Geoffrey Sher answered

Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or immunologic factors. IVF success rates…
IVF Failure & Pregnancy Loss May 8, 2023

Recurrent pregnancy loss- known graves disease

I am 36 y/o and have five pregnancies, with one living child delivered at 36 wks (spontaneous birth). Hyperthyroidism caused by Graves disease is my only chronic medical condition. My husband and I have both been genetically tested. The RE… — Sade S.

Dr. Geoffrey Sher answered

Currently, with few exceptions, practitioners of assisted reproduction tend to attribute “unexplained and/or repeated” IVF failure(s), almost exclusively to poor embryo quality, advocating adjusted protocols for ovarian stimulation and/or gamete and embryo preparation as a potential remedy. The idea, having failed IVF, that all it takes to ultimately…
Embryos & Genetic Testing May 8, 2023

Implantation failure

Hi doctor , I have pgt a tested embryos which failed in 3 FET. My frozen embryos are over now and I’m diagnosed with ssa ro positive and all other tests negative. I was given intralipids last two times and… — Rakshitha R.

Dr. Geoffrey Sher answered

Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or immunologic factors. IVF success rates…
Embryos & Genetic Testing May 5, 2023

Recurrent Pregnancy Loss and Recurrent Implantation Failure

We have been dealing with fertility issues for 18 months. Last year, I had three early miscarriages (all at less than 8 weeks). These miscarriages occurred back-to-back-to-back within a 7 month period. We were referred to an REI. Since then,… — Morgan H.

Dr. Geoffrey Sher answered

Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or immunologic factors. IVF success rates…
IVF Failure & Pregnancy Loss May 4, 2023

Ivf failure

Dear Dr Sher, I have listened to the egg whisperer podcast and I am currently a fertility patient in a clinic in Germany. I had a successful ivf in 2020 (2nd attempt) which resulted in a healthy baby and are… — Michelle G.

Dr. Geoffrey Sher answered

Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or immunologic factors. IVF success rates…
Embryos & Genetic Testing May 1, 2023

Implantation Failure

Hi! I have had two FETs with embryos made with my wifes egg and sperm donor, PGT tested and good quality. Both times did not work. I am 28 years old, have had many tests, Hysteroscopy, Uterine Imaging, etc and… — Ann S.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
IVF Failure & Pregnancy Loss Apr 28, 2023

Repeated ivf failures

Hi there I just turned 43 in January and live in Vancouver. Over the last year I have done 5 standard ivf cycles and 1 mini ivf cycle and have never gotten a blastocyst on any cycle. We did a… — Kat L.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
IVF Failure & Pregnancy Loss Apr 18, 2023

Ivf failure

Hi Dr I am 30 years I had failed Ivf 3 times . Recently undergone Ivf and freezes 18 eggs . I have high AMH and bulky ovary. Should I go ahead and do Ivf cycle scheduled May or postponed… — Martam C.

Dr. Geoffrey Sher answered

The high AMH is no reason to postpone! Geoff Sher
IVF Failure & Pregnancy Loss Apr 16, 2023

How to improve next time

Hi Dr Sher. I'm 33 yrs old, and my husband is 40. I developed uterine scarring in 2019 after a D&C from an incomplete miscarriage. I was cleared to try again after several hysteroscopies. After 2 failed IVFs, I finally… — Rashida J.

Dr. Geoffrey Sher answered

I agree with you! Clearly you had post=pregnancy endometritis that compromised the basal (germinal layer) of you endometrium. This could absolutely explain your implantation dysfunction.Unfortunate, this kind of injury is often refractory to treatment but it is worth a try with vaginal Viagra and Estradiol to see if…
Early Pregnancy & hCG Apr 4, 2023

Scared to Try Again

Hi Dr. Sher, Thank you for taking my question. I am 28 years old who conceived naturally and unfortunately experienced a miscarriage three weeks ago. I was 14 weeks and this was my first pregnancy. Everything I have read online… — Kay M.

Dr. Geoffrey Sher answered

WE should talk! The commonest causes of mid-trimester miscarriage are: 1. Cervical incompetency 2. Uterine congenital anomaly (e.g. a septum 3. Uterine anatomical pathology (e.g. fibroids; adenomyosis; post surgical scarring; endo-uterine synecheae 4. Placental failure due to vascular or immunologicic causes 5. Developmental fetal abnormalities (genetic and multifactorial)…
IVF Failure & Pregnancy Loss Mar 27, 2023

Laparoscopy for endometriosis after failed ivf

Hi Dr. Sher , I have scheduled a robotic assisted laparoscopy to remove the endometriomas off of my ovaries based on your advice last year . My procedure description is “robotic assisted laparoscopy , lysis of adhesions , resection /… — Mindy D.

Dr. Geoffrey Sher answered

I think we should talk! Please call my assistant, Patti Converse at 702-533-2691 and set up an online consultation with me to discuss! When women with infertility due to endometriosis seek treatment, they are all too often advised to first try ovarian stimulation (ovulation Induction) with intrauterine insemination…
Hormones & Ovulation Mar 24, 2023

2 failed cycles, No transfer

Hi Dr Sher I’m a 30 year old living in London. I have had 2 IVF cycles, but after both, all embryos stopped growing after 2-3 days post egg retrieval. I was also told I have mild PCO in my… — Abi S.

Dr. Geoffrey Sher answered

Very respectfully, this is not likely to be a uniform genetic issue. More than likely ity has to do with the protocol used for ovarian stimulation (see below). The importance of the IVF stimulation protocol on egg/embryo quality cannot be overstated. This factor seems often to be overlooked…
Hormones & Ovulation Mar 16, 2023

2 Failed FETs

Hi Dr Sher, first of all thank you for taking the time to read my question. I am 35 years old, and I just had my 2nd failed FET. On both occasions we transferred a 5aa hatching embryo non PGT… — Alisa W.

Dr. Geoffrey Sher answered

I think we should talk. P)lease consider calling my assistant, Patti Converse at 702-533-2691 to set up an online consultation with me. Geoff Sher Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to,…
Egg Health & Ovarian Reserve Mar 15, 2023

3rd failed IVF and problem with egg maturity

Hello Dr Sher, First of all I would like to thank you in advance for giving me a chance to ask you a question and for answering if. I really appreciate it. I am 33 years old, have a good… — Stephanie K.

Dr. Geoffrey Sher answered

One of the commonest questions asked by patients undergoing IVF relates to the likelihood of their eggs fertilizing and the likely “quality of their embryos. This is also one of the most difficult questions to answer. On the one hand many factors that profoundly influence egg quality; such…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

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