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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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Embryos & Genetic Testing Dec 5, 2023

Secondary Infertility

Hi Dr Sher Ive watched the egg whisper Dr aimee talk to you about implantation failure and I wanted to ask you your advice, I messaged you a few years ago and was very grateful for your response and advice,… — Ayesha A.

Dr. Geoffrey Sher answered

I am so happy that you ultimately succeeded. But now you do have the biological clock working against your egg/embryo quality. The most important determinant is no doubt the issue of egg/embryo quality. Here,age, ovarian reserve and your husband's sperm dysfunction all are the most important operative variables.…
Embryos & Genetic Testing Nov 30, 2023

Immune System issues

I just had a miscarriage at 5 weeks 4 days of a tested normal embryo 5 day AA PGT . And I tried to get pregnant for over 10 years. I was told I had an immunity disorder years ago,… — Sheyla M.

Dr. Geoffrey Sher answered

Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success…
Embryos & Genetic Testing Nov 30, 2023

Embryo testing

Hi, dr. Sher! Do you recomend PGT (NGS) on day 3 embryos? I m 51 and have two day 3 embryos and my clinic want to biopsy now, because they think they won' t make it to day 5. I… — Polona B.

Dr. Geoffrey Sher answered

Absolutely not! They should wait to see if they reach blastocyst and then biopsy for PGS/PGT. Remember, embryos that do not reach blastocysts are all abnormal anyway and would never have propagated a viable pregnancy had they been transferred earlier. Geoff Sher PLEASE SHARE THIS WITH OTHERS AND…
Embryos & Genetic Testing Nov 27, 2023

PGT-A embryos

Hi i recently just had a blighted ovum and was wondering wht really causes blighted ovums? The embryo was tested and it was a donor egg with my husband's sperm... can a normal embryo still b "normal " if the… — Susan K.

Dr. Geoffrey Sher answered

If the embryo was chromosomally normal, then you should consider the possibility that this due to implantation dysfunction. IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES. Geoffrey Sher MD Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially…
Embryos & Genetic Testing Nov 27, 2023

Miscarriage and Adenomyosis

Hi there I am 39 and since 33 have had recurrent miscarriages. I had two at 6.5 weeks and then a live baby and then 1 at 6.5 weeks that had two trisomies when tested. During that third miscarriage I… — Sophie T.

Dr. Geoffrey Sher answered

Adenomyosis can compromise implantation, but in my opinion this only occurs when the endometrial lining at the time of ovulation, hCG "trigger" or when progesterone treatment begins in cases of FET/embryo adoption etc. In fact in most cases adenomyosis is found in women who have had several babies,…
Embryos & Genetic Testing Nov 20, 2023

Embryo grading

other Hi Dr. Sher, I have two embryos frozen on day 3 (not day 5 for some reason). . One embryo is 8 cell grade 1 and the other is 10 cell grade 1. Are these good quality embryos? What… — Sherry P.

Dr. Geoffrey Sher answered

This is very much dependent on your age and the clinical underlying circumstances. While ordinarily anything better than a 5c day-3 embryo are positive feature3s, there are many other considerations. If you wanted better comfort, I would suggest these 2 embryos be thawed, carried to blastocyst and biopsied…
Embryos & Genetic Testing Nov 2, 2023

embryo adoption

nd can use own eggs/embryos. I am a current patient. 2 failed ivf. High NK. Myself and husband have 2 variants of MTHFR I did intralipids in both. I was wondering if we would have better chances if we used… — Shontae S.

Dr. Geoffrey Sher answered

No, I do not think you need to go on Lovenox and use own eggs/embryos. Hereditary Clotting Defects (Thrombophilia) Geoffrey Sher MD Thrombophilia (Hereditary Clotting Defect) is defined as the genetic predisposition to developing intravascular thrombosis. It is due to hypercoagulability of blood leading to impairment of initial…
Egg Health & Ovarian Reserve Nov 2, 2023

Egg freezing risks in IVF

Hello Dr. Sher I am 39, childless and I'm currently undergoing IVF in Portugal. I have had 4 miscarriages in the past (2 clinical and 2 chemicals). On my last scan, my AFC was 15. My AMH is 1.24. I… — Lisa-Marie E.

Dr. Geoffrey Sher answered

I concur. I would collect as many eggs as possible in advance. "Empowering Choices: Embryo Banking vs. Egg Banking for Fertility Preservation" Geoffrey Sher MD It's crucial for women to make informed decisions about preserving their fertility. Delaying trying to conceive, relying on egg freezing, or assuming the…
Embryos & Genetic Testing Oct 20, 2023

Ivf

I want to knw why my embryos failed to grow at the 1st attempt of ivf ...and is the any hope or solution for me if go for the 2nd attempt — Onkarabetse R.

Dr. Geoffrey Sher answered

We should talk! Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS) ; http://sherfertilitysolutions.com/sher-fertility-solutions-ebook.pdf Recurrent Pregnancy Loss and Unexplained IVF Failure: The Immunologic…
Embryos & Genetic Testing Oct 18, 2023

SET vs. DET

I read through your website in your opinion of how many embryos to transfer. Would your recommendation change in the case of multiple failed euploid transfers in someone under 35? I have done all of the recommended testing and have… — Tasha T.

Dr. Geoffrey Sher answered

If multiple euploid embryo transfers have failed, you likely have an implantation dysfunction and it wont matter whether you transfer 1 or 2 embryos...outcome would be the same. What is needed is ti identify and address the cause of the implantation failure (see below). IVF FAILURE WITH “NORMAL”…
Egg Health & Ovarian Reserve Oct 9, 2023

Poor Fertilization and Embryo Quality

Hello. I had an egg retrieval last week - 75 eggs collected, 1/2 normal insemination and 1/2 ICSI. 0 eggs fertilized with normal insemination. In the ICSI group (38 eggs) - 25 mature, 12 fertilized, 1 graded 3BB blast at… — Nkoli A.

Dr. Geoffrey Sher answered

I suspect it has to do with the ovarian stimulation protocol rather than an inherent egg quality deficit. Geoff Sher Empowering Choices: Embryo Banking vs. Egg Banking for Fertility Preservation" Geoffrey Sher MD It's crucial for women to make informed decisions about preserving their fertility. Delaying trying to…
Embryos & Genetic Testing Oct 4, 2023

Mosaic on chromosome 18

Hi Dr you come so highly recommended. Would you transfer an embro with 35% mosaicism on chromosome 18? My current gyanae thinks it'll correct itself in the womb. Thank you — Neelam R.

Dr. Geoffrey Sher answered

No doubt a tough call....I would transfer BUT would do an early CVS or amniocentesis to make certain that the baby was OK...leaving open the option to terminate, if not so! Good luck and G-d bless! Geoff Sher Herewith are online links to 2 E-books recently co-authored with…
Embryos & Genetic Testing Sep 27, 2023

Accuracy of Quad Screening

We are 20 weeks and have our anatomy scan next week. Very anxious! Day 5 4AA euploid embryo. Quad screen levels all looked perfect at 16 weeks. Is it safe to relax now? Does a tested high-quality embryo with a… — Mary P.

Dr. Geoffrey Sher answered

I would all-but stop worrying at this stage`. Geoff Sher PLEASE SHARE THIS WITH OTHERS AND HELP SPREAD THE WORD!! Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: From In Vitro Fertilization to Family: A…
Embryos & Genetic Testing Sep 25, 2023

IVF protocol

My name is Polona, I'm 50 and I've done four IVF cycles, all in North Cyprus, two of them when I was 48 and two of them at 50, for the last one I changed clinics. I’m planning to do… — Polona B.

Dr. Geoffrey Sher answered

Dear Polona, I cannot in good faith support a decision to do IVF with own eggs at 50y of age. The chance of success is virtually zero, regardless of ovarian reserve. You should exclusively be focused on egg donation. Understanding the impact of age and ovarian reserve on…
Embryos & Genetic Testing Sep 25, 2023

What is left to try?

Hello, I’m at 38 year old, female with low ovarian reserve and type 1 diabetes. My partner has male infertility, requiring tese. We had a successful IVF pregnancy with a day 3 embryo in 2018. For the last two years… — Alexa A.

Dr. Geoffrey Sher answered

We need to talk. Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

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