– Geoffrey Sher, MD
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Embryos & Genetic Testing
Buenos días Dr, Soy de Madrid, España. Me acabo de transferir un embrión mosaico de Bajo Grado (30%) para trisomía del cromosoma 6. Me ha implantado, pero por mas que intento buscar información y casos que hayan ido bien, no… — Maria L.
Dr. Geoffrey Sher answered
Please post in English! Geoff Sher
Embryos & Genetic Testing
I'm almost 40 y/o. I've had 4 failed IUIs and two egg retrievals, resulting in only 1 euploid from 47 total eggs retrieved. My fertilization and blast rates are "average" to above average, but my maturity rates are very low.… — Jessica W.
Dr. Geoffrey Sher answered
"Empowering Choices: Embryo Banking vs. Egg Banking for Fertility Preservation" It's crucial for women to make informed decisions about preserving their fertility. Delaying trying to conceive, relying on egg freezing, or assuming the biological clock can be paused are misconceptions. As women age, egg quality declines, affecting the…
Embryos & Genetic Testing
Hi. I have 4 abnormally PGS tested donated embryos. The normally tested ones either didn’t implant or I miscarried. I even did the ERA scratch, and other testing to make sure my uterus was good. Anyway, can abnormal embryos be… — Gina T.
Dr. Geoffrey Sher answered
Abnormal, non-mosaic embryos (aneuploid should not be transferred. IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES. Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses…
Embryos & Genetic Testing
Hi Dr. Sher, I heard you on an episode of the Egg Whisperer. I have high testosterone from PCOS and have had one implantation failure and two chemical pregnancies. Could the high testosterone be the cause? My embryos were not… — Allison B.
Dr. Geoffrey Sher answered
Navigating Polycystic Ovary Syndrome: Understanding, Hope, and Treatment Understanding the intricate interplay of hormones and the impact on egg development empowers us to create personalized protocols, offering hope for improved egg quality and ultimately optimizing the chances of successful IVF for women with PCOS. Polycystic ovary syndrome (PCOS)…
Egg Health & Ovarian Reserve
I am 30, my husband is 29. I was diagnosed with PCOS at 15. I had a miscarriage at age 20 at 8 weeks. Last year, I had three miscarriages (one at 6 weeks, 5 weeks and then at 4… — Kristina H.
Dr. Geoffrey Sher answered
Respectfully, I do not concur with the suggested approach. You have recurrent pregnancy loss. I suggest you read the articles I wrote , below and then seriously consider calling my assistant, Patti Converse at 702-533-to set up an online consultation with me to discuss your case in detail.…
Early Pregnancy & hCG
My hcg level is 306 on 30/12/2023. LMP 18/11/2023. Abdominal ultrasound shows no embryo sac.Any complications? — Rizvana T.
Dr. Geoffrey Sher answered
Sadly, This sounds like a non-viable pregnancy. Going through IVF is a major investment, emotionally, physically, and financially, for every patient or couple. One of the most crucial moments is receiving the result of the blood test for human chorionic gonadotropin (hCG) pregnancy. It's a big deal! The…
Embryos & Genetic Testing
Hello! My husband and I are doing IVF because he has ADPKD and we are trying to chose an embryo without that condition. We thankfully produced two healthy embryos (female) and one male without the ADPKD gene, negative segmental aneuploidy… — Loren S.
Dr. Geoffrey Sher answered
Human embryo development is a marvel of intricate processes, including reprogramming, sequential cleavage divisions, mitotic chromosome segregation, and embryonic genome activation. However, the journey towards a successful pregnancy is not without its challenges, as chromosomal abnormalities can occur during germ cell and preimplantation embryo development, leading to early…
Embryos & Genetic Testing
Hi Dr. Sher, This has been a long journey. I did a fresh transfer at 38 (got 18 eggs, 5 to blast stage, but we did not test then), the fresh transfer resulted in a chemical. Had to take some… — Mary R.
Dr. Geoffrey Sher answered
On the face of it, this sounds very much like3 "implantation dysfunction). Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as…
Clinic & Practice
Hi Dr. Sher, My husband and I struggled with infertility and failed with IVF. Now we are pursuing embryo donation and we were matched with a couple whose embryos are stored at your clinic. We live in Rochester, NY and… — Mayumi K.
Dr. Geoffrey Sher answered
Absolutely, we often do this. It would probably take no more than 4-5 visits at our center over a 10 day period of time. all the time! More and more American women are exploring IVF treatments in their late 30s and in their 40s. This trend often stems…
Embryos & Genetic Testing
Hello. My last retrieval only resulted in Day 7 embryos, which we sent for PGT testing. We have 1 euploid Day 7 and 1 Low level mosiac (segemental low level with deletion of of chromosome 15 on the q25.3 arm… — Sumi G.
Dr. Geoffrey Sher answered
Respectfully, in my experience day 7 blastocysts are not worthy of transfer. They rarely iuf ever, will propagate viable pregnancies. Geoff Sher Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1. From In Vitro Fertilization…
Egg Health & Ovarian Reserve
Hi Dr Sher, On the 5th day of my FSH treatment with Gonal-F only, I made a mistake and used Pergoveris instead of Gonal-F (same dosage), It's the same follitropin alfa, but I am afraid of the LH surge, that… — Jennifer S.
Dr. Geoffrey Sher answered
I don't think it will be a problem. I would not cancel...but discuss with your own RE. Geoff Sher PLEASE SHARE THIS WITH OTHERS AND HELP SPREAD THE WORD!! Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your…
Early Pregnancy & hCG
Medication plan help: I am currently going through IVF. I have one PGT-tested embryo. My last two pregnancies, as soon as I fell pregnant, I experienced severe bleeding. First pregnancy - natural conception - bleeding started on day 33 and… — Abs G.
Dr. Geoffrey Sher answered
Protocols differ from clinic tom clinic. While interesting, the information provided here is not comprehensive enough for me to provide an adequate opinion. I suggest you call my assistaznt, patti Converse at 702-533-2691 and set up an online consultation with me to discuss. Good luck! Geoff Sher PLEASE…
Egg Health & Ovarian Reserve
I have suspected endometriosis and very low ovarian reserve. Should I do a laparoscopy for endometriosis, then PRP therapy to increase my ovarian reserve before I retry IVF? Will this help? My last two attempts at IVF have only ever… — Aqsa G.
Dr. Geoffrey Sher answered
Unless you need surgery because of intractable symptoms or you require surgical treatment of ovarian endometriomas, I would not advocate laparoscopy at all. Your miscarriages could well be due to endometriosis-induced , immunologic implantation dysfunction. When women with endometriosis-related infertility seek treatment, they are often advised to try…
Embryos & Genetic Testing
Buenas tardes Dr El resultado del examen PGT de mi esposa fue Sample ID Sample Barcode Result Sex Chromosomes Impacted Interpretation LB1 2023061467 Aneuploid XY +9 Abnormal LB2 2023061467 Mosaic XY -Y [mos] Low Level Mosaic Aconseja implantar el LB2… — Jose S.
Dr. Geoffrey Sher answered
Please re-post in English! Geoff Sher PLEASE SHARE THIS WITH OTHERS AND HELP SPREAD THE WORD!! Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1. From In Vitro Fertilization to Family: A Journey with Sher…
Egg Health & Ovarian Reserve
I am currently 33 years old and have already had 3 ICSIs. However, the first one was 5 years ago. Last year I stimulated for 2 days with 375 Gonal f and 75 Menopur and then with 225 Gonal f… — Monika O.
Dr. Geoffrey Sher answered
“Empty Follicle Syndrome" is a misleading term because follicles always contain eggs. However, some eggs may have difficulties detaching and being retrieved. This is more likely to happen when multiple attempts are needed to retrieve an egg from a follicle, indicating the egg may have chromosomal abnormalities. The…
