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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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Page 51 of 68

Egg Health & Ovarian Reserve Apr 15, 2023

What next?

Hi Dr Sher, we are a couple aged 35 and 34. We had 2 natural pregnancies which resulted in first trimester miscarriages. We later found out that my husband has balanced translocation and I have low amh of about 0.8ng/ml… — Sofia C.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
Male Infertility Apr 15, 2023

Husband with low sperm motility, lifespan and concentration

Hello, I am a 38 year old woman who just completed a failed round of IVF today. I live in Canada and wonder if we don't have the IVF advancements perhaps as there is in the USA. I am healthy,… — Kristyn W.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
Egg Health & Ovarian Reserve Apr 12, 2023

low immature oocytes

Hello, I had a failed IVF cycle. I am 34, healthy (No smoking, healthy diet, yoga 3 times a week), BMI 22 and doing IVF due to male infertility reasons. My Dr gave me the short protocol, my body responded… — Rana N.

Dr. Geoffrey Sher answered

I do not believe that this is likely to be due to an intrinsic egg issue. It is likely due to the type of protocol used and/or the type and typing/dosage/timing of the "trigger". We really need to talk. I suggest you call my assistant, Patti Converse at…
Third-Party Reproduction Apr 12, 2023

Thin endometrium 3 years after successful egg donor pregnancy

I had my first egg donor transfer at 43 years old and it was successful. Had a c-section with no complications. Now I am 47 years old and wanted to try once more. This time I have had 4 transfer… — Alicia C.

Dr. Geoffrey Sher answered

It is possible that with established menopause, the chronically low estradiol has suppressed endometrial estrogen receptors, rendering the lining refractory to short-term estrogen stimulation. In my opinion you s might try a few months of cyclical estrogen/progesterone therapy to try and prime the endometrium (reawaken estrogen receptor response).…
Egg Health & Ovarian Reserve Apr 12, 2023

Low amh clomid protocol advice

n online consultation with me to discuss.Hello, I'm almost 39yo with an amh of 0.3 and 6 follicles at baseline. Trying for a second child. Started a max dose ivf antagonist protocol and responded really fast, 7 days of stim… — Yasmin G.

Dr. Geoffrey Sher answered

Respectfully, In my opinion neither mini-IVF nor clomiphene is good in women with diminished ovarian reserve. It is primarily the egg (rather than the sperm) that determines the chromosomal integrity (karyotype) of the embryo, the most important determinant of egg/embryo competency”. A “competent” egg is therefore one that…
Egg Health & Ovarian Reserve Apr 11, 2023

Poor egg quality

Hello Dr Sher. I am a 34 yo F with spouse 43 yo M. G0P0, dx with unexplained infertility. BMI 22, no PMH and no male factors based on SA. Placed on levothyroxine during initial work up to bring TSH… — Aradhna S.

Dr. Geoffrey Sher answered

I think we should talk! Please consider calling my assistant, Patti Converse at 702-533-2691 and setting up an online consultation with me to discuss your case in detail.: One of the commonest questions asked by patients undergoing IVF relates to the likelihood of their eggs fertilizing and the…
Immunology & Implantation Apr 10, 2023

immunologic implantation dysfunction

I have had several miscarriages the last 2 after IVF but I've never been tested for autoimmune implantation dysfunction even though I have Lupus, Celiac disease, and Rheumatoid arthritis. I have 2 frozen embryos and am 47. My current husband… — Sabrina P.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being lost within 10 weeks of conception (in the…
Immunology & Implantation Apr 10, 2023

2 failures with Donor Eggs

Hi Dr. Sher, I’m writing you at a complete loss and low point in my treatment. I am 34. My husband is 41. We started to try to conceive when I was age 31 and within 3 months, I became… — Alyssa J.

Dr. Geoffrey Sher answered

There is very likely to be an implantation dysfunction. We should talk. I suggest you call my assistant, Patti Converse (702-533-02691 and set up an online consultation with me. Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. In the pursuit of optimizing outcome…
Embryos & Genetic Testing Apr 7, 2023

immunological incompatibility

Dear Dr. Sher, Thank you very much for your prompt response. Maybe I should have told you a bit of my story. I am 37 years old and last year I had 3 abortions (week 7+5, week 5 and week… — Lis A.

Dr. Geoffrey Sher answered

Please contact my assistant Patti (702-533-2691) after the Easter weekend and set up an online consultation with me to discuss in detail. Geoff Sher
Immunology & Implantation Apr 7, 2023

immunological incompatibility

I would like you, please to help me to understand our results from KIR HLA-C test: My KIR: KIR2DL1: positive KIR2DL2: negative KIR2DL3: positive KIR2DL4: positive KIR2DL5: positive KIR2DS1: positive KIR2DS2: negative KIR2DS3: negative KIR2DS4: positive KIR2DS5 : positive KIR3DL1:… — Lis A.

Dr. Geoffrey Sher answered

I am sorry...these are not the tests I would advise/order to look for an alloimmune , immunologic implantation dysfunction. Alone, the results would be of negligible help to me. Geoff Sher In the United States, effective treatment of NK/CTL activation associated with either alloimmune or autoimmune implantation dysfunction…
Ovarian Stimulation & OHSS Apr 7, 2023

OHSS

Hello Dr. Sher, Further to my question about OHSS…are there any long term implications such as cancer? — Yael G.

Dr. Geoffrey Sher answered

Not to my knowledge! Geoff Sher
Immunology & Implantation Apr 4, 2023

Intralipids with Hashimotos

Hello, I am wondering whether I should have intralipids with my next IVF cycle (donor egg). I have Hashimotos and have heard that the soy in intralipids can aggravate Hashimotos. In my last cycle my TSH rose from 1.6 to… — Gemma B.

Dr. Geoffrey Sher answered

__ Between 2% and 5% of women of the childbearing age have reduced thyroid hormone activity (hypothyroidism). Women with hypothyroidism often manifest with reproductive failure i.e. infertility, unexplained (often repeated) IVF failure, or recurrent pregnancy loss (RPL). The condition is 5-10 times more common in women than in…
Early Pregnancy & hCG Apr 4, 2023

Scared to Try Again

Hi Dr. Sher, Thank you for taking my question. I am 28 years old who conceived naturally and unfortunately experienced a miscarriage three weeks ago. I was 14 weeks and this was my first pregnancy. Everything I have read online… — Kay M.

Dr. Geoffrey Sher answered

WE should talk! The commonest causes of mid-trimester miscarriage are: 1. Cervical incompetency 2. Uterine congenital anomaly (e.g. a septum 3. Uterine anatomical pathology (e.g. fibroids; adenomyosis; post surgical scarring; endo-uterine synecheae 4. Placental failure due to vascular or immunologicic causes 5. Developmental fetal abnormalities (genetic and multifactorial)…
Uterine & Endometrial Health Apr 4, 2023

Should I try again?

Hi Dr. Sher - I'm 34 yrs old, and developed uterine scaring after an incomplete miscarriage 4 years ago. Scaring was cleared and I have done 1 IVF and 4 rounds of IUI, but they all ultimately failed due to… — Jennifer I.

Dr. Geoffrey Sher answered

It was as far back as 1989, when I first published a study that examined the correlation between the thickness of a woman’s uterine lining (the endometrium), and the subsequent successful implantation of embryos in IVF patients. This study revealed that when the uterine lining measured
Ovarian Stimulation & OHSS Apr 4, 2023

Ohss

Hello Dr.Sher, I am interested to know what your thoughts are on my situation. I am starting my first egg retrieval in the upcoming months and I’m 40 years old, with lean pcos (5’7 and 130 lbs) and with an… — Yael G.

Dr. Geoffrey Sher answered

Polycystic ovary syndrome (PCOS) is a common hormonal system disorder among women affecting between 5% and 10% of women of reproductive age worldwide. Women with PCOS may have enlarged ovaries that contain multiple small collections of fluid (subcapsular microcysts) that are arranged like a “string of pearls” immediately…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

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