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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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Hormones & Ovulation Jul 12, 2025

FET

Hello! I had a recent FET just a few days ago. On the day oftransfer, my progesterone was 37 and estradiol was 1700. This estradiol level is considerably higher than it was for my last successful FET. So I am… — Eugenia T.

Dr. Geoffrey Sher answered

The E2 level, ideally, should be 500-100pg/ml on the day progesterone treatment starts. Endometrial thickness is measured also on the day progesterone starts. It needs to be >8mm with a trilaminar ultrsound appearance, The thickness on the day of transfer is not significant. See the article below, on…
Embryos & Genetic Testing Jun 23, 2025

Dup(13)(q21.1-qter)[mos]

DI have a high level mosaic Dup(13)(q21.1-qter)[mos] tested by Cooper. My doctor had incureged me to transfer but genetic councilor seemed concerned. What do you think? — Veselina M.

Dr. Geoffrey Sher answered

I agree with your doctor unless there is a pressing reason to 1st do another cycle using a modified/improved protocol for ovarian stimulation to try and access more euploid embryos for use. Geoff Sher Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY…
IVF Failure & Pregnancy Loss Jun 23, 2025

Implantation failure regarding

Hello Doctor, I have a query regarding repeated implantation failure. I have low amh and my spouse has severe Oligoasthenoteratozoospermia(only 2 sperm found even under the highest resolution). So we opted for donor eggs and donor sperms. But overall I… — Shilpa M.

Dr. Geoffrey Sher answered

IMPLANTATION DYSFUNCTION Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors.…
Embryos & Genetic Testing Jun 23, 2025

Testing

I have a history of-two failed FET Embryos were not tested Embryos were not tested at 37 years old. I did two more rounds of IVF and I have now 7 euploids with CCRM I also did a lap to… — Michelle F.

Dr. Geoffrey Sher answered

They are wrong with regard to the Receptiva test. It is very helpful in diagnosing silent endometriosis which if present can be associated with an immunologic implantation dysfunction (IID) I am not a believer in Emma/Alice testing and ; The method of FET will not affect the risk…
Early Pregnancy & hCG Jun 11, 2025

First pregnancy scan after IVF with PGT

Hi, I've recently discovered I'm pregnant through IVF with an euploid embryo. I had my first beta HCG blood test at 12 days past transfer and this came back at 540 IU/L. I'm now waiting for my first scan in… — Mary D.

Dr. Geoffrey Sher answered

Congratulations!! I wish I could predict. Unfortunately you will need to wait for the US result! Good luck! Geoff Sher
Embryos & Genetic Testing Jun 5, 2025

Blighted Ovum

I just had my first FET, and it resulted in a blighted ovum. I am 35 years old with 5 PGT abnormal eggs. We will try again in a few months. But in the meantime, is there anything I should… — Kate S.

Dr. Geoffrey Sher answered

I would need much more information to provide an authoritative opinion. Feel free to contact my assistant, Patti (concierge@sherivf.com to set up an online consultation with me. to discuss. Geoffrey Sher MD ADDITIONAL INFORMATION: Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY…
Clinic & Practice Jun 5, 2025

IVF second opinion

I need a second opinion. I am 35 years old on my first round of IVF after 2 failed IUIs. I have been trying for a year to get pregnant. I have AMH level of .112 and 7 follicles. This… — Gweneth V.

Dr. Geoffrey Sher answered

Thank you for reaching out. I will do my best to help: Given your diminished ovarian reserve; IUI is definitely not for you. The success rate is far too low and you do not have the time to spare. You do need IVF but unless an individualized protocol…
Fertility Preservation May 29, 2025

Egg freezing

Hello there I need some information I’m from Texas wanting to do egg freezing looking for bowl part of course No insurance I saw someone on TikTok talking about your clinic so wanted to get lucky I’m 42 my AMH… — Mona R.

Dr. Geoffrey Sher answered

For more than 50 years, scientists have been working to perfect the art of freezing and storing a woman's eggs, also known as “egg banking”. Although there have been challenges, the progress has been both amazing and is promising. Since the birth of the first "frozen egg baby"…
Egg Health & Ovarian Reserve May 29, 2025

Stimulation protocols for DOR in 45 yr old

I'm trying to write up the protocol outlined in one of your recent videos with the egg whisper to take to my Dr. whom is going to do my next cycle. We've started the HGH and we did the PRP… — Ariane B.

Dr. Geoffrey Sher answered

I would never presume tom tell your doctor what to do with regard to your stimulation. I can tell you that regardless of protocol, the chance of propagating euploid ("competent") eggs at 45y is very slim (!:2o eggs or so will end up being viable). Obviously if in…
Embryos & Genetic Testing May 29, 2025

Slow frozen

Dear Dr Sher! We have a patient who has 6 slow-frozen embryos. She wants to donated them to another family. WE attempted to find a recipient family for her; however, most fertility clinics do not want to accept slow frozen… — Alena W.

Dr. Geoffrey Sher answered

If they were frozen on day-3...indeed you could do that. But if they were frozen as blastocysts, the thaw-biopsy-refreeze can damage the embryos. Good luck Geoff Sher ADDITIONAL INFORMATION: Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your…
Immunology & Implantation May 29, 2025

Dexamethasone for FET

What would be the reason for using Dexamethasone (short 5 day course) leading up to FET vs using Prednisone? I feel like prednisone is more commonly prescribed for this purpose, but my doctor said there is no difference. I recently… — Renee G.

Dr. Geoffrey Sher answered

The two are by and large interchangeable. The steroid administration should start at the beginning of the cycle and continue to the 10th week. It should then be tailed off over 2 weeks. Geoff Sher _ In the world of assisted reproduction, when IVF fails repeatedly or without…
Early Pregnancy & hCG May 8, 2025

LIT in pregnancy

Hi Dr, My partner and I are a partial DQ Alpha match so had 2x LIT treatment, one before transfer and one at 6 weeks and ongoing intralipids bi-weekly. I am currently 15 weeks pregnant with scans looking good. I… — Victoria L.

Dr. Geoffrey Sher answered

UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending…
Immunology & Implantation May 8, 2025

Implantation Failure – BCL6, immature nk cells & APS

Hello Dr, After multiple implantation failure, I was diagnosed with anti-phospholipid syndrom (managed with daily asprin and in case of pregnancy clexane) but also high inflammation marker BCL6 (though no endometriosis) and immature NK cells / low local immune activation… — Kate F.

Dr. Geoffrey Sher answered

I have strong suspicion that you have an immunologic implantation dysfunction. IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES. Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are…
Egg Health & Ovarian Reserve Apr 27, 2025

Lack of maturation of eggs in stimulation cycle

Dear Dr. Sher, I just watched your video on egg maturation and learned more than I have in over a year of reading and asking questions on this. My question also relates to egg maturation but specifically on why eggs… — Laura C.

Dr. Geoffrey Sher answered

When confronted with such an exaggerated response, doctors often trigger egg maturation by cutting the cycle short through triggering early. While this protects against OHSS, the eggs are oft yet not ready for maturation. This leads mto "poor egg yield and quality . Second, in such cases doctors…
Early Pregnancy & hCG Apr 27, 2025

betaHCG

Dear Dr.Sher, I have a missed miscarriage last year and I am pregnant again 6 weeks. My betas were doubling nice until they crossed the 10000 and drop from 53 h DT to 108 DT. At this point I am… — Alice D.

Dr. Geoffrey Sher answered

I am not overly concerned. The le3vels often tail off somewhat around this time. Do an US confirmation ASAP. Good luck! Geoff Sher

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

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