– Geoffrey Sher, MD
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Early Pregnancy & hCG
Hi, I've recently discovered I'm pregnant through IVF with an euploid embryo. I had my first beta HCG blood test at 12 days past transfer and this came back at 540 IU/L. I'm now waiting for my first scan in… — Mary D.
Dr. Geoffrey Sher answered
Congratulations!! I wish I could predict. Unfortunately you will need to wait for the US result! Good luck! Geoff Sher
Embryos & Genetic Testing
I just had my first FET, and it resulted in a blighted ovum. I am 35 years old with 5 PGT abnormal eggs. We will try again in a few months. But in the meantime, is there anything I should… — Kate S.
Dr. Geoffrey Sher answered
I would need much more information to provide an authoritative opinion. Feel free to contact my assistant, Patti (concierge@sherivf.com to set up an online consultation with me. to discuss. Geoffrey Sher MD ADDITIONAL INFORMATION: Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY…
Clinic & Practice
I need a second opinion. I am 35 years old on my first round of IVF after 2 failed IUIs. I have been trying for a year to get pregnant. I have AMH level of .112 and 7 follicles. This… — Gweneth V.
Dr. Geoffrey Sher answered
Thank you for reaching out. I will do my best to help: Given your diminished ovarian reserve; IUI is definitely not for you. The success rate is far too low and you do not have the time to spare. You do need IVF but unless an individualized protocol…
Fertility Preservation
Hello there I need some information I’m from Texas wanting to do egg freezing looking for bowl part of course No insurance I saw someone on TikTok talking about your clinic so wanted to get lucky I’m 42 my AMH… — Mona R.
Dr. Geoffrey Sher answered
For more than 50 years, scientists have been working to perfect the art of freezing and storing a woman's eggs, also known as “egg banking”. Although there have been challenges, the progress has been both amazing and is promising. Since the birth of the first "frozen egg baby"…
Egg Health & Ovarian Reserve
I'm trying to write up the protocol outlined in one of your recent videos with the egg whisper to take to my Dr. whom is going to do my next cycle. We've started the HGH and we did the PRP… — Ariane B.
Dr. Geoffrey Sher answered
I would never presume tom tell your doctor what to do with regard to your stimulation. I can tell you that regardless of protocol, the chance of propagating euploid ("competent") eggs at 45y is very slim (!:2o eggs or so will end up being viable). Obviously if in…
Embryos & Genetic Testing
Dear Dr Sher! We have a patient who has 6 slow-frozen embryos. She wants to donated them to another family. WE attempted to find a recipient family for her; however, most fertility clinics do not want to accept slow frozen… — Alena W.
Dr. Geoffrey Sher answered
If they were frozen on day-3...indeed you could do that. But if they were frozen as blastocysts, the thaw-biopsy-refreeze can damage the embryos. Good luck Geoff Sher ADDITIONAL INFORMATION: Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your…
Immunology & Implantation
What would be the reason for using Dexamethasone (short 5 day course) leading up to FET vs using Prednisone? I feel like prednisone is more commonly prescribed for this purpose, but my doctor said there is no difference. I recently… — Renee G.
Dr. Geoffrey Sher answered
The two are by and large interchangeable. The steroid administration should start at the beginning of the cycle and continue to the 10th week. It should then be tailed off over 2 weeks. Geoff Sher _ In the world of assisted reproduction, when IVF fails repeatedly or without…
Early Pregnancy & hCG
Hi Dr, My partner and I are a partial DQ Alpha match so had 2x LIT treatment, one before transfer and one at 6 weeks and ongoing intralipids bi-weekly. I am currently 15 weeks pregnant with scans looking good. I… — Victoria L.
Dr. Geoffrey Sher answered
UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending…
Immunology & Implantation
Hello Dr, After multiple implantation failure, I was diagnosed with anti-phospholipid syndrom (managed with daily asprin and in case of pregnancy clexane) but also high inflammation marker BCL6 (though no endometriosis) and immature NK cells / low local immune activation… — Kate F.
Dr. Geoffrey Sher answered
I have strong suspicion that you have an immunologic implantation dysfunction. IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES. Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are…
Egg Health & Ovarian Reserve
Dear Dr. Sher, I just watched your video on egg maturation and learned more than I have in over a year of reading and asking questions on this. My question also relates to egg maturation but specifically on why eggs… — Laura C.
Dr. Geoffrey Sher answered
When confronted with such an exaggerated response, doctors often trigger egg maturation by cutting the cycle short through triggering early. While this protects against OHSS, the eggs are oft yet not ready for maturation. This leads mto "poor egg yield and quality . Second, in such cases doctors…
Early Pregnancy & hCG
Dear Dr.Sher, I have a missed miscarriage last year and I am pregnant again 6 weeks. My betas were doubling nice until they crossed the 10000 and drop from 53 h DT to 108 DT. At this point I am… — Alice D.
Dr. Geoffrey Sher answered
I am not overly concerned. The le3vels often tail off somewhat around this time. Do an US confirmation ASAP. Good luck! Geoff Sher
Early Pregnancy & hCG
Hi! I have a history of recurrent miscarriage but also have 2 living children. I’ve been exposed to mold in the past so had recent testing done. Many of my IgE antibodies to mold/mycotoxins were high, suggesting a current mold… — Sarah R.
Dr. Geoffrey Sher answered
I honestly doubt that this is what has caused your miscarriages,. But discuss it with your primarybcare OB/GYN. Geoff Sher
Hormones & Ovulation
Hello, I was wondering what the recommended parameters are for TSH level prior to FET. My most recent TSH level was 4.01, just wondering if these are good numbers for going into transfer. I’m 35 and low AMH(0.98). Just want… — Maria S.
Dr. Geoffrey Sher answered
Your elevated TSH could indicate an underlying hypothyyroid state which could be due to an autoimmune condition andf your low AMH points towards iminished ovarian reserve (DOR: 1. Thyroid Autoimmunity (TAI) & Immunologic Implantation Dysfunction (IID) Between 2% and 5% of women of the childbearing age have reduced…
Early Pregnancy & hCG
Thank you for receive me, what if my LH level is higher (15,45 mIU/ml on Day 3 of menstrual cycle — Paola U.
Dr. Geoffrey Sher answered
I would need much more information. If you would like to discuss your case with me , email my assistant (702-533-2691 and set up an online consultation with me,
Egg Health & Ovarian Reserve
Hi, I'm on my first round of ivf due to same sex relationship. Im from the UK. I have just had my first egg retrieval and I'm bitterly disappointed with the amount of egg they collected. I'm 37, amh 14.1,… — Katie M.
Dr. Geoffrey Sher answered
Empty Follicle Syndrome" is a misleading term because follicles always contain eggs. However, some eggs may have difficulties detaching and being retrieved. This is more likely to happen when multiple attempts are needed to retrieve an egg from a follicle, indicating the egg may have chromosomal abnormalities. The…
