The question
Dear Dr. Sher,
I just watched your video on egg maturation and learned more than I have in over a year of reading and asking questions on this.
My question also relates to egg maturation but specifically on why eggs may not mature in a stimulation cycle. I am 35 years old and had two retrieval cycles with around 35 eggs retrieved in each cycle, of which only 10 were mature each time (with the majority remaining 25 being germinal vesicle and many M1). This happened in both cycles. I understand that this ratio of maturity is unusual. Do you know why that might that be? Does it mean those 25 immature eggs would have been dismature and incompetent either way?
Many, many thanks in advance, kindest regards,
Laura
Answer from Dr. Geoffrey Sher
When confronted with such an exaggerated response, doctors often trigger egg maturation by cutting the cycle short through triggering early. While this protects against OHSS, the eggs are oft yet not ready for maturation. This leads mto "poor egg yield and quality . Second, in such cases doctors often trigger using a GnRH agonist (alone) to reduce risk of OHSS on your well-being. Once again, such an approach, while protecting you, does so at the expense of egg "competency". What you probably need is a complete revision of tour protocol for ovarian stimulation.
In invite you to contact bmy assistant, Patti converse (comcierge@Sherivf.com) and set up an online consultation with me to discuss in detail.
Geoff Sher
General information only, not medical advice for your own situation. For that, book a consultation.