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Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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Dr. Geoffrey Sher

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Embryos & Genetic Testing Jan 21, 2026

Recurrent Pregnancy Loss

I have a history of autoimmune and clotting issues possibly contributing to recurrent pregnancy loss (4 losses, 2 from IVF) and currently have 6 frozen PGT-A tested embryos at Shady Grove Fertility (4 euploid, 2 mosaic). I no longer have… — Katie B.

Dr. Geoffrey Sher answered

UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending…
Clinic & Practice Jan 21, 2026

Question

We wanna to know how much consultation it's cost — Irina G.

Dr. Geoffrey Sher answered

Please call my office Manager, Patti at 702-533-2691 and inquire with her. Geoff Sher
Embryos & Genetic Testing Jan 21, 2026

EMBRYO

Hello Dr. Sher, I have 2 embryos frozen in 2021. I am now looking to implant. Embryo 1: - Gardner Score: BG3CB - KIDScore: 4.6 - NGS: Euploid Embryo 2: - Gardner Score: BG4AA - KIDScore: 9.3 - NGS: Low… — Anu A.

Dr. Geoffrey Sher answered

The euploid embryo!
Uterine & Endometrial Health Jan 21, 2026

Endometriosis

Dr. Sher, I successfully cycled with you in April 2004 in the NYC office. I also gave birth to another child naturally (miraculously after an ectopic 6 months after I had my child through IVF). My second child is now… — Sara N.

Dr. Geoffrey Sher answered

Please have her reach out to my Office Manager, Patti Converse (conciege@sherivf.com and set up a consultation online, with me. Geoff Sher ENDOMETRIOSIS: A RATIONAL BASIS FOR IVF Endometriosis is a condition where the uterine lining (endometrium) grows on pelvic structures outside the uterine cavity. In early stage-…
Egg Health & Ovarian Reserve Jan 21, 2026

Research papers on trigger dosage for POI/DOR patients

Dear Dr. Sher, with great interest have I read your articles on the "empty" follicle syndrome: I was diagnosed with premature ovarian insufficiency incl. elevated LH levels. In my two egg retrieval attempts only 1 egg could be retrieved out… — Lena T.

Dr. Geoffrey Sher answered

I suggest you email Patti Converse (concierge@sherivf.com and set up an online consultation with me. Geoff Sher
Uterine & Endometrial Health Jan 21, 2026

ERA testing

Dr. Geoffrey Sher answered

i PERSONALLY AM NOT A BIG BELIEVER IN THE VALUE OF ERA TESTING. GEOFF SHER
Infertility Basics Jan 21, 2026

unexplained infertility age 33

I have unexplained infertility, age 33, partner 29. We have done all the testing(HSG,bloodwork,ultrasounds) and everything looks very normal. AMH 1.1 (which I’ve been told is a little low for my age but still normal). We have tried for 1.5… — Nour N.

Dr. Geoffrey Sher answered

UNEXPLAINED” INFERTILITY: A RATIONAL APPROACH TO MANAGEMENT Infertility affects y 10%-15% of couples who are unable to conceive. In some cases, the cause of infertility cannot be determined using conventional diagnostic methods, leading to a diagnosis of "unexplained infertility." However, it is important to note that in most…
Ovarian Stimulation & OHSS Jan 21, 2026

Fresh or frozen transfer

I’m currently on a short antagonist with a fresh cycle, following my egg retrieval the doctor noted she could see triple layer endometrium but there was no triple layer detected in the most recent scan so mentioned as she didn’t… — Louise S.

Dr. Geoffrey Sher answered

Yes you can go ahead. However, please be aware that 30% of women with endometriosis (regardless of severity, havd an immunologic implantation dysfunction (see below) which needs treatment. Geoff Sher Contact my Office manager..for appointment: Concierge@sherivf.com ENDOMETRIOSIS AND IMMUNOLOGIC IMPLANTATION FAILURE. Patients with endometriosis have immunologic abnormalities. The…
Ovarian Stimulation & OHSS Nov 14, 2025

Agonist/Antagonist Conversion protocol-meds

Hello Dr. Sher. I have a question about the Agonist/Antagonist Conversion protocol I am to start this protocol, and I wonder if it matters if I use Menopur or Gonal-F/Follistim during the stimulation? The reason for this question is that… — Liz S.

Dr. Geoffrey Sher answered

Embarking on the journey of in vitro fertilization (IVF) can be a daunting experience especially for women with sub-normal AMH levels (diminished ovarian reserve -DOR). Here is a novel and highly effective protocol known as the Agonist/Antagonist Conversion Protocol (A/ACP), designed to optimize the chances of success for…
Age & Fertility Nov 12, 2025

Reoccurring GeneticRisk

I am turning 41 in a couple weeks and unfortunately just had to make the heart wrenching choice to medically terminate our Trisomy 21 pregnancy at 13 weeks. Two years ago, I had a miscarriage/ D&C due to Trisomy 10.… — Kim S.

Dr. Geoffrey Sher answered

The cause of your trisomy pregnancy was likely age-related egg aneuploidy. The chance of an embryo having the right chromosomal configuration declines with with advancing age. Since you already have several children, you might want to stop. However, since you et pregnant quite easily on your own, and…
Immunology & Implantation Nov 6, 2025

Reproductive Immunology

Hello, I have had two, late, second trimester losses, back to back. Both of these losses have happened since I was diagnosed with a rare autoimmune, eosinophillic esophagitis. What is your familiarity with reproductive immunology and how likely is there… — Kathryn C.

Dr. Geoffrey Sher answered

In the world of assisted reproduction, when IVF fails repeatedly or without explanation, it's often assumed that poor embryo quality is the main culprit. However, this view oversimplifies the situation. The process of embryo implantation, which begins about six or seven days after fertilization, involves a complex interaction…
Hormones & Ovulation Nov 6, 2025

High testosterone during hormone suppression prior to fet

Hi I am currently doing suppression before embryo transfer. I am almost 2 month into suppression with lupron depot, letrozole, and norethindrone. I had done 2 months of suppression with just lupron about 6 months ago before a transfer that… — Holly F.

Dr. Geoffrey Sher answered

A high testosterone has an adverse effect on egg/embryo quality and endometriosis can adversely affect embryo attachment (implantation) through an immune mechanism. Feel free to email my assistant, Patti (concierge@sherivf.com if you wish to discuss your case with me online. Geoff Sher
Ovarian Stimulation & OHSS Nov 6, 2025

DOR,age,IVF

Hello, dear doctor. Listened to you podcast and been blown away by your expertise! I am a youthful 45 year old trying to get pregnant. Gotten pregnant 2 years ago naturally, but miscarried in week 9. Had done 3 IVF… — Maja S.

Dr. Geoffrey Sher answered

Understanding the impact of age and ovarian reserve on the success of in vitro fertilization (IVF) is crucial when it comes to reproductive health. This article aims to simplify and clarify these concepts, emphasizing their significance in the selection of ovarian stimulation protocols for IVF. By providing you…
Early Pregnancy & hCG Nov 6, 2025

Heavy bleeding after possible implantations

Hi, I've had two egg collections resulting in 5 embryos (3 of which didn't survive thawing) and 3 on the second round. In my first fresh embryo transfer I passed a couple of large blood clots the day after transfer,… — Megan M.

Dr. Geoffrey Sher answered

IMPLANTATION DYSFUNCTION Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors.…
Ovarian Stimulation & OHSS Oct 14, 2025

4th IVF cycle questions on microdose flare protocol

Hello Dr. Sher, I am 42 yrs old with a low AMH (less than 1) trying to get pregnant for the 2nd time. My first pregnancy was natural when I was 38. I started my 2nd fertility journey with IUI… — Terri M.

Dr. Geoffrey Sher answered

At 42 years of age and especially if you are experiencing diminishing ovarian reserve, a flare protocol (in my opinion) is less than ideal. I suggest you call my assistant, Patti at 702-533-2691 and set up an online consultation with me. Geoff Sher EGG/ EMBRYO QUALITY IN IVF…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

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