– Geoffrey Sher, MD
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IVF Failure & Pregnancy Loss
MY WIFE HAD 2 CONSECUTIVE COMPLETE MOLAR PREGANANCIES AT AGE 24 AND 25. THEN SHE APPROACHED IVF, AND RETURNED A MALE EMBRYO BASED ON DR. SHER'S ARRICLE IN 2016 AS SOLUTION TO PREVENT A COMPLETE MOLE. MY QUESTION NOW, IS… — Ahmad A.
Dr. Geoffrey Sher answered
Not to my knowledge! Sorry! Geoff Sher
IVF Failure & Pregnancy Loss
At20weeksinmyivfpregnacymycervixdilatedandledtostillbirth.what could be the reason — N R.
Dr. Geoffrey Sher answered
This sounds like cervical incompetence . You likely leaked fluids after the membranes ruptured and the fetus was infected. This is something that can be treated through the insertion of a cervical cerclage. Discuss it with your Obstetrician. Geoff Sher
IVF Failure & Pregnancy Loss
I was excited to see the depth of understanding and research regardingRPL.i am having my third miscarriage at6-7weeks. Could I schedule a telehealth consult? — Jane M.
Dr. Geoffrey Sher answered
Absolutely you can. Email my assistant, Patti Converse at concierge@sherivf.com with your telephone # and she will call you right back and set this up. Geoff Sher Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure:…
Immunology & Implantation
Dear dr Sher, I got my first child 2020 via embryodonation (34 yo) on the first attempt with HRT. I had low AMH and endo. Since 2024 we had 3 more embryotransfers (1 was PGT-a) tested with the same male… — Anna L.
Dr. Geoffrey Sher answered
We should really discuss this at length. It sounds to me as if you have an implantation dysfunction. Please read the article below and if interested in having an online consultation with me, contact my assistant, Patti Converse (concierge@sherivf.com) and set up an online consultation with me to…
Embryos & Genetic Testing
We have had 1 successful implantation which ended in a miscarriage at 8 weeks. 1 chemical pregnancy and 4 failed implantation - 3 of which were with euploid embryos. Husband has poor SA (varicocele) and I have been diagnosed with… — Z M.
Dr. Geoffrey Sher answered
Respectfully, Elevated DFI does not negatively affect implantation. What you are experiencing is likely an implantation dysfunction which could be "immunologic" in origin and linked to endometriosis....see below. I suggest you contact my assistant, Patti Converse (concierge@sherivf.com and ask her to set up with an online consultation with…
Immunology & Implantation
Hello! I am writing to you about my current pregnancy… I have a chronic spontaneous allergy, and since several bumps appeared on my body, my hCG is no longer increasing as it should (21.02-5300/24.02-7800/26.02-8030)… I have two miscarriages, I know… — Patricia C.
Dr. Geoffrey Sher answered
Please read the article below. Thereupon, if you wish to have an online consultation with me to discuss you case in detail, please contact my assistant, Patti Converse (concierge@sherivf.com) and she will set this up. Geoffrey Sher MD UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When…
Embryos & Genetic Testing
I am a 42 year old women undergoing IVF treatment. I had a very successful egg retrieval (13 fertilized eggs, 9 blastocyst, after PGT-A testing: 3 euploid embryos and 1 low mosaic). We transfered our 3rd euploid embryo 2 weeks… — Lindsey M.
Dr. Geoffrey Sher answered
At 42y, IUI is definitely not the answer..please read below and thereupon (if so inclined) contact my assistant, Patti Converse (concierge@sherivf.com) and have her set up an online consultation with me. IMPLANTATION DYSFUNCTION Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially…
Immunology & Implantation
Good morning Dr. Sher, My name is Xuandao ("Dao") Nguyen, I'm 42 yo and currently in round 4 of IVF at my local clinic here in Atlanta (ACRM). I want to give you a brief summary of my case and… — Xuandao N.
Dr. Geoffrey Sher answered
In my opinion, you have a likely implantation dysfunction . It could be anatomical or immunologic. I suggest you contact my assistant, Patti at concierge@sherIVF.com to set up an online consultation with me. Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially…
Embryos & Genetic Testing
Hello, my name is Vikki Carpenter. I am 40 years old and started IVF last year. I have one IVF failure (chemical), and 7 other chemical pregnancies before IVF. The pattern is virtually the same: I get pregnant and within… — Vikki C.
Dr. Geoffrey Sher answered
UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending…
IVF Failure & Pregnancy Loss
Dear Dr. Sher, My husband and I are trying to get pregnant for a while. The last test that they performed was taking a tissue sample from my uterus, and the results showed periglandular clusters in NK cells (CD138). My… — Silvia H.
Dr. Geoffrey Sher answered
IMPLANTATION DYSFUNCTION Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors.…
Embryos & Genetic Testing
I had 3 natural pregnancies that ended up in miscarriages and 3 embryos pgt tested implanted that failed. I want to know the cause — Joyce M.
Dr. Geoffrey Sher answered
UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending…
Embryos & Genetic Testing
Dear Dr. Sher, Thank you for the detailed article on immunological issues of embryo implantation failures. I'm writing to you as a fertility patient in France. After a certain number of blastocysts transfered with a single implantation and early miscarriage,… — Manon G.
Dr. Geoffrey Sher answered
I aplaud any research that serves to uncover the immunologic basis for implantation dysfunction. Endometrial local immunity is likely an important parameter that influences implantation and the the prognosis of pregnancy.. Diagnosis of an endometrial immune dysregulation . It seeks to assess embryo-endometrial interaction and focuses on several…
Embryos & Genetic Testing
Dear Dr. Sher, Myself and husband are both 38 yrs old started our fertility journey at the age of 32 yrs so trying to conceive for 6 yrs now. We started with ovulation induction, had an ectopic treated with methotrexate.… — Remy A.
Dr. Geoffrey Sher answered
Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success…
Immunology & Implantation
Hi there, We had a son nearly 5 years ago within a few months of trying (cesarian), since then we have had a blighted ovum, 1 chemical pregnancy, 1 6 week miscarriage trisomy 8, and 10 failed implantations (of high… — Sean T.
Dr. Geoffrey Sher answered
This sounds very much like an anatomical implantation dysfunction (see below). I suggest we talk. Please contact my assistant, Patti Converse at 702-533-2691 to set this up. Geoff Sher IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES. Implantation dysfunction is often overlooked as a…
IVF Failure & Pregnancy Loss
Hi, I have RPL, and have 4 miscarriages this last year. Now done IVF with 13 eggs, 11 fertilized and only 2 made blasto at day 6. I have RA, mild endo. I take enbrel 50 mg 1xw and my… — Helene N.
Dr. Geoffrey Sher answered
When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent pregnancy…
